Autonomic and respiratory consequences of altered chemoreflex function: clinical and therapeutic implications in cardiovascular diseases.
Arrhythmias
Baroreflex
Chemoreflex
Ergoreflex
Heart failure
Hypertension
Sleep apnoea
Journal
European journal of heart failure
ISSN: 1879-0844
Titre abrégé: Eur J Heart Fail
Pays: England
ID NLM: 100887595
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
revised:
10
02
2023
received:
14
09
2022
accepted:
26
02
2023
medline:
19
6
2023
pubmed:
13
3
2023
entrez:
12
3
2023
Statut:
ppublish
Résumé
The importance of chemoreflex function for cardiovascular health is increasingly recognized in clinical practice. The physiological function of the chemoreflex is to constantly adjust ventilation and circulatory control to match respiratory gases to metabolism. This is achieved in a highly integrated fashion with the baroreflex and the ergoreflex. The functionality of chemoreceptors is altered in cardiovascular diseases, causing unstable ventilation and apnoeas and promoting sympathovagal imbalance, and it is associated with arrhythmias and fatal cardiorespiratory events. In the last few years, opportunities to desensitize hyperactive chemoreceptors have emerged as potential options for treatment of hypertension and heart failure. This review summarizes up to date evidence of chemoreflex physiology/pathophysiology, highlighting the clinical significance of chemoreflex dysfunction, and lists the latest proof of concept studies based on modulation of the chemoreflex as a novel target in cardiovascular diseases.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
642-656Informations de copyright
© 2023 European Society of Cardiology.
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