Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores.
alphavirue
biochemistry
membrane proteins
structural biology
virology
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
21 03 2023
21 03 2023
Historique:
entrez:
13
3
2023
pubmed:
14
3
2023
medline:
16
3
2023
Statut:
ppublish
Résumé
Alphaviruses are emerging positive-stranded RNA viruses which replicate and transcribe their genomes in membranous organelles formed in the cell cytoplasm. The nonstructural protein 1 (nsP1) is responsible for viral RNA capping and gates the replication organelles by assembling into monotopic membrane-associated dodecameric pores. The capping pathway is unique to Alphaviruses; beginning with the N
Identifiants
pubmed: 36913573
doi: 10.1073/pnas.2213934120
pmc: PMC10041110
doi:
Substances chimiques
Antiviral Agents
0
Guanosine Triphosphate
86-01-1
RNA Caps
0
RNA, Viral
0
S-Adenosylmethionine
7LP2MPO46S
Viral Nonstructural Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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