Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations.
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
20
12
2021
accepted:
23
01
2023
entrez:
14
3
2023
pubmed:
15
3
2023
medline:
16
3
2023
Statut:
ppublish
Résumé
Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of the protein-coding regions of the genome identified a causal role for ten genes and a concentration of rare variant signals in evolutionarily constrained genes
Identifiants
pubmed: 36914870
doi: 10.1038/s41588-023-01305-1
pii: 10.1038/s41588-023-01305-1
pmc: PMC10011128
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
369-376Subventions
Organisme : NIMH NIH HHS
ID : R01 MH104964
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113619
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH123451
Pays : United States
Investigateurs
Henry S Aghanwa
(HS)
Moin Ansari
(M)
Aftab Asif
(A)
Rubina Aslam
(R)
Jose L Ayuso
(JL)
Tim Bigdeli
(T)
Stefano Bignotti
(S)
Julio Bobes
(J)
Bekh Bradley
(B)
Peter Buckley
(P)
Murray J Cairns
(MJ)
Stanley V Catts
(SV)
Abdul Rashid Chaudhry
(AR)
David Cohen
(D)
Brett L Collins
(BL)
Angèle Consoli
(A)
Javier Costas
(J)
Benedicto Crespo-Facorro
(B)
Nikolaos P Daskalakis
(NP)
Michael Davidson
(M)
Kenneth L Davis
(KL)
Faith Dickerson
(F)
Imtiaz A Dogar
(IA)
Elodie Drapeau
(E)
Lourdes Fañanás
(L)
Ayman Fanous
(A)
Warda Fatima
(W)
Mar Fatjo
(M)
Cheryl Filippich
(C)
Joseph Friedman
(J)
John F Fullard
(JF)
Penelope Georgakopoulos
(P)
Marianna Giannitelli
(M)
Ina Giegling
(I)
Melissa J Green
(MJ)
Olivier Guillin
(O)
Blanca Gutierrez
(B)
Herlina Y Handoko
(HY)
Stella Kim Hansen
(SK)
Maryam Haroon
(M)
Vahram Haroutunian
(V)
Frans A Henskens
(FA)
Fahad Hussain
(F)
Assen V Jablensky
(AV)
Jamil Junejo
(J)
Brian J Kelly
(BJ)
Shams-Ud-Din A Khan
(SA)
Muhammad N S Khan
(MNS)
Anisuzzaman Khan
(A)
Hamid R Khawaja
(HR)
Bakht Khizar
(B)
Steven P Kleopoulos
(SP)
James Knowles
(J)
Bettina Konte
(B)
Agung A A A Kusumawardhani
(AAAA)
Naeemullah Leghari
(N)
Xudong Liu
(X)
Adriana Lori
(A)
Carmel M Loughland
(CM)
Khalid Mahmood
(K)
Saqib Mahmood
(S)
Dolores Malaspina
(D)
Danish Malik
(D)
Amy McNaughton
(A)
Patricia T Michie
(PT)
Vasiliki Michopolous
(V)
Esther Molina
(E)
María D Molto
(MD)
Asim Munir
(A)
Gerard Muntané
(G)
Farooq Naeem
(F)
Derek J Nancarrow
(DJ)
Amina Nasar
(A)
Tanvir Nasr
(T)
Jude U Ohaeri
(JU)
Jurg Ott
(J)
Christos Pantelis
(C)
Sathish Periyasamy
(S)
Ana G Pinto
(AG)
Abigail Powers
(A)
Belén Ramos
(B)
Nusrat H Rana
(NH)
Mark Rapaport
(M)
Abraham Reichenberg
(A)
Safaa Saker-Delye
(S)
Ulrich Schall
(U)
Peter R Schofield
(PR)
Rodney J Scott
(RJ)
Megan Shanahan
(M)
Cynthia Shannon Weickert
(CS)
Calvin Sjaarda
(C)
Heather J Smith
(HJ)
Jose Javier Suárez-Rama
(JJ)
Muhammad Tariq
(M)
Florence Thibaut
(F)
Paul A Tooney
(PA)
Muhammad Umar
(M)
Elisabet Vilella
(E)
Mark Weiser
(M)
Jin Qin Wu
(JQ)
Robert Yolken
(R)
Informations de copyright
© 2023. The Author(s).
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