Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA-binding protein 1.
Journal
Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400
Informations de publication
Date de publication:
14 03 2023
14 03 2023
Historique:
entrez:
14
3
2023
pubmed:
15
3
2023
medline:
17
3
2023
Statut:
ppublish
Résumé
Cellular stress granules arise in cells subjected to stress and promote cell survival. A cellular protein that localizes to stress granules is Z-DNA-binding protein 1 (ZBP1), which plays a major role in necroptosis, a programmed cell death pathway mediated by the kinase RIPK3. Here, we showed that the stress granule inducer arsenite activated RIPK3-dependent necroptosis. This pathway required ZBP1, which localized to arsenite-induced stress granules. RIPK3 localized to stress granules in the presence of ZBP1, leading to the formation of ZBP1-RIPK3 necrosomes, phosphorylation of the RIPK3 effector MLKL, and execution of necroptosis. Cells that did not form stress granules did not induce necroptosis in response to arsenite. Together, these results show that arsenite induces ZBP1-mediated necroptosis in a manner dependent on stress granule formation.
Identifiants
pubmed: 36917643
doi: 10.1126/scisignal.abq0837
pmc: PMC10561663
mid: NIHMS1895479
doi:
Substances chimiques
arsenite
N5509X556J
Arsenites
0
DNA-Binding Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabq0837Subventions
Organisme : NIAID NIH HHS
ID : R01 AI095394
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES030838
Pays : United States
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