New paradigms in purinergic receptor ligand discovery.
Adenosine receptor
Drug discovery
GPCR ion Channel
P2X receptor
P2Y receptor
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
01 06 2023
01 06 2023
Historique:
received:
05
01
2023
revised:
28
02
2023
accepted:
11
03
2023
pmc-release:
01
06
2024
medline:
28
3
2023
pubmed:
16
3
2023
entrez:
15
3
2023
Statut:
ppublish
Résumé
The discovery and clinical implementation of modulators of adenosine, P2Y and P2X receptors (comprising nineteen subtypes) have progressed dramatically in ∼50 years since Burnstock's definition of purinergic signaling. Although most clinical trials of selective ligands (agonists and antagonists) of certain purinergic receptors failed, there is a renewed impetus to redirect efforts to new disease conditions and the discovery of more selective or targeted compounds with potentially reduced side effects, such as biased GPCR agonists. The elucidation of new receptor and enzyme structures is steering rational design of potent and selective agonists, antagonists, allosteric modulators and inhibitors. A
Identifiants
pubmed: 36921890
pii: S0028-3908(23)00093-X
doi: 10.1016/j.neuropharm.2023.109503
pmc: PMC10233512
mid: NIHMS1884019
pii:
doi:
Substances chimiques
Ligands
0
Receptors, Purinergic
0
Adenosine
K72T3FS567
Purinergic P1 Receptor Antagonists
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
109503Subventions
Organisme : Intramural NIH HHS
ID : Z01 DK031116
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 DK031117
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK031116
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK031117
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors (KAJ, BP, ZW, and AP) declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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