Mechanistic Investigation of the Time-Dependent Aldehyde Oxidase Inhibitor Hydralazine.

Rats Animals Humans Aldehyde Oxidase / metabolism Catalase Tandem Mass Spectrometry Dantrolene Hydralazine / pharmacology Phthalazines / metabolism Glutathione

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
06 2023
Historique:
received: 11 01 2023
accepted: 10 03 2023
medline: 15 5 2023
pubmed: 16 3 2023
entrez: 15 3 2023
Statut: ppublish

Résumé

The anti-hypertensive agent hydralazine is a time-dependent inhibitor of the cytosolic drug-metabolizing enzyme aldehyde oxidase (AO). Glutathione (GSH) was found to suppress the inhibition of AO by hydralazine in multiple enzyme sources (human liver and kidney cytosol, human liver S9, rat liver S9, and recombinant human AO) and with different AO substrates (zoniporide,

Identifiants

DOI: 10.1124/dmd.123.001257 PMID: 36921993
pubmed: 36921993
pii: dmd.123.001257
doi: 10.1124/dmd.123.001257
doi:

Substances chimiques

Aldehyde Oxidase EC 1.2.3.1
Catalase EC 1.11.1.6
Dantrolene F64QU97QCR
Hydralazine 26NAK24LS8
Phthalazines 0
Glutathione GAN16C9B8O

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

782-791

Informations de copyright

Copyright © 2023 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

J Paige Barnes (JP)

Department of Pharmacy and Pharmaceutical Sciences, Lipscomb University College of Pharmacy, Nashville, Tennessee (J.P.B., S.M.Y., T.S.T., C.M.G., S.S.P., T.Q.D., R.D.C.); and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee (R.D.C.).

Shaoyun M Yang (SM)

Department of Pharmacy and Pharmaceutical Sciences, Lipscomb University College of Pharmacy, Nashville, Tennessee (J.P.B., S.M.Y., T.S.T., C.M.G., S.S.P., T.Q.D., R.D.C.); and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee (R.D.C.).

Taylor S Thompson (TS)

Department of Pharmacy and Pharmaceutical Sciences, Lipscomb University College of Pharmacy, Nashville, Tennessee (J.P.B., S.M.Y., T.S.T., C.M.G., S.S.P., T.Q.D., R.D.C.); and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee (R.D.C.).

Caithlyne M Guevarra (CM)

Department of Pharmacy and Pharmaceutical Sciences, Lipscomb University College of Pharmacy, Nashville, Tennessee (J.P.B., S.M.Y., T.S.T., C.M.G., S.S.P., T.Q.D., R.D.C.); and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee (R.D.C.).

Shaniya S Pleasant (SS)

Department of Pharmacy and Pharmaceutical Sciences, Lipscomb University College of Pharmacy, Nashville, Tennessee (J.P.B., S.M.Y., T.S.T., C.M.G., S.S.P., T.Q.D., R.D.C.); and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee (R.D.C.).

Tri Q Do (TQ)

Department of Pharmacy and Pharmaceutical Sciences, Lipscomb University College of Pharmacy, Nashville, Tennessee (J.P.B., S.M.Y., T.S.T., C.M.G., S.S.P., T.Q.D., R.D.C.); and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee (R.D.C.).

Rachel D Crouch (RD)

Department of Pharmacy and Pharmaceutical Sciences, Lipscomb University College of Pharmacy, Nashville, Tennessee (J.P.B., S.M.Y., T.S.T., C.M.G., S.S.P., T.Q.D., R.D.C.); and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee (R.D.C.) rachel.crouch@lipscomb.edu.
ORCID: 0000-0002-4525-6072

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Mechanistic Investigation of the...
questionsmedicales.fr › Eucaryotes › Animaux › Mechanistic Investigation of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mechanistic Investigation of the...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on aldehyde or oxo group donors › Aldehyde oxidoreductases › Aldehyde oxidase › Mechanistic Investigation of the...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Peroxidases › Catalase › Mechanistic Investigation of the...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Mechanistic Investigation of the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Imidazolidines › Hydantoïnes › Dantrolène › Mechanistic Investigation of the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridazines › Phtalazines › Hydralazine › Mechanistic Investigation of the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridazines › Phtalazines › Mechanistic Investigation of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Mechanistic Investigation of the...