Theoretical quantification of the polyvalent binding of nanoparticles coated with peptide-major histocompatibility complex to T cell receptor-nanoclusters.

Receptors, Antigen, T-Cell / chemistry Peptides / metabolism T-Lymphocytes Major Histocompatibility Complex Protein Binding Nanoparticles
Cooperativity Density of bound and triggered TCRs Dissociation constant Gibbs free energy Insertion probability Multiscale model Polyvalent biding T cell receptors TCR nanoclusters pMHC-coated nanoparticles

Journal

Mathematical biosciences
ISSN: 1879-3134
Titre abrégé: Math Biosci
Pays: United States
ID NLM: 0103146

Informations de publication

Date de publication:
04 2023
Historique:
received: 30 09 2022
revised: 06 03 2023
accepted: 08 03 2023
medline: 5 4 2023
pubmed: 17 3 2023
entrez: 16 3 2023
Statut: ppublish

Résumé

Nanoparticles (NPs) coated with peptide-major histocompatibility complexes (pMHCs) can be used as a therapy to treat autoimmune diseases. They do so by inducing the differentiation and expansion of disease-suppressing T regulatory type 1 (Tr1) cells by binding to their T cell receptors (TCRs) expressed as TCR-nanoclusters (TCR

Identifiants

DOI: 10.1016/j.mbs.2023.108995 PMID: 36924879
pubmed: 36924879
pii: S0025-5564(23)00036-6
doi: 10.1016/j.mbs.2023.108995
pii:
doi:

Substances chimiques

Receptors, Antigen, T-Cell 0
Peptides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108995

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Manuela Pineros-Rodriguez (M)

Department of Mathematics and Statistics, McGill University, Montreal, Canada.

Louis Richez (L)

Quantitative Life Sciences Program, McGill University, Montreal, Canada.

Anmar Khadra (A)

Department of Physiology, McGill University, Montreal, Canada. Electronic address: anmar.khadra@mcgill.ca.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Theoretical quantification of the polyvalent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Theoretical quantification of the polyvalent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Theoretical quantification of the polyvalent...
questionsmedicales.fr › Phénomènes du système immunitaire › Phénomènes immunogénétiques › Complexe majeur d'histocompatibilité › Theoretical quantification of the polyvalent...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Theoretical quantification of the polyvalent...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Theoretical quantification of the polyvalent...