TrypTag.org: from images to discoveries using genome-wide protein localisation in Trypanosoma brucei.

Trypanosoma brucei brucei / genetics Protozoan Proteins / genetics Protein Transport
high-throughput imaging kinetoplastid molecular cell biology trypanosome

Journal

Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034

Informations de publication

Date de publication:
05 2023
Historique:
received: 24 10 2022
revised: 19 02 2023
accepted: 19 02 2023
medline: 17 4 2023
pubmed: 17 3 2023
entrez: 16 3 2023
Statut: ppublish

Résumé

TrypTag was a 4-year project to tag the N- and C-termini of almost all Trypanosoma brucei proteins with a fluorescent protein and record the subcellular localisation through images and manual annotation. We highlight the new routes to cell biological discovery this transformative resource is enabling for parasitologists and cell biologists.

Identifiants

DOI: 10.1016/j.pt.2023.02.008 PMID: 36925446
pubmed: 36925446
pii: S1471-4922(23)00041-7
doi: 10.1016/j.pt.2023.02.008
pii:
doi:

Substances chimiques

Protozoan Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

328-331

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Jack D Sunter (JD)

Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK. Electronic address: jsunter@brookes.ac.uk.

Samuel Dean (S)

Warwick Medical School, University of Warwick, Coventry, UK. Electronic address: samuel.dean@warwick.ac.uk.

Richard John Wheeler (RJ)

Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address: richard.wheeler@ndm.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma brucei brucei › TrypTag.org: from images to discoveries using...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de protozoaire › TrypTag.org: from images to discoveries using...
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des protéines › TrypTag.org: from images to discoveries using...