Quantitative PET tracking of intra-articularly administered

Rats Animals Tissue Distribution Senotherapeutics Deferoxamine / chemistry Positron-Emission Tomography / methods Peptides Lipids Cell Line, Tumor
Drug delivery systems Intra-articular injection Nanoemulsions PET imaging Radiolabeled peptide Senolytic peptide

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
04 2023
Historique:
received: 21 11 2022
revised: 17 02 2023
accepted: 14 03 2023
medline: 5 4 2023
pubmed: 18 3 2023
entrez: 17 3 2023
Statut: ppublish

Résumé

Intra-articular (IA) administration of drugs for the treatment of diseases such as rheumatoid arthritis, osteoarthritis and psoriatic arthritis is a common strategy; however, the rapid clearance from the synovial fluid restricts their effectivity due to the limited retention time. Drug Delivery Systems (DDS) are currently being developed to increase their joint retention time. This study compares the biodistribution and retention time of a senolytic peptide (PEP), with potential application in osteoarthritis disease, and this senolytic peptide encapsulated in a DDS based on a lipid nanoemulsion (PEPNE) by using positron emission tomography (PET) imaging. To this aim, the PEP was conjugated with a chelating agent (DFO) and radiolabeled with zirconium-89 (

Identifiants

DOI: 10.1016/j.jconrel.2023.03.025 PMID: 36931471
pubmed: 36931471
pii: S0168-3659(23)00192-X
doi: 10.1016/j.jconrel.2023.03.025
pii:
doi:

Substances chimiques

Senotherapeutics 0
Deferoxamine J06Y7MXW4D
Peptides 0
Lipids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

702-713

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Auteurs

Sandra Díez-Villares (S)

Nano-Oncology and Translational Therapeutics Group, Health Research Institute of Santiago de Compostela (IDIS), SERGAS, Santiago de Compostela 15706, Spain; University of Santiago de Compostela (USC), Santiago de Compostela 15706, Spain; Biomedical Research Networking Center on Oncology (CIBERONC), Madrid 28029, Spain.

Lara García-Varela (L)

Molecular Imaging Biomarkers Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela (USC), Santiago de Compostela 15706, Spain; Nuclear Medicine Department and Molecular Imaging Group, Health Research Institute of Santiago de Compostela (IDIS), SERGAS, Santiago de Compostela 15706, Spain.

Soraya Groba-de Antas (SG)

Nano-Oncology and Translational Therapeutics Group, Health Research Institute of Santiago de Compostela (IDIS), SERGAS, Santiago de Compostela 15706, Spain; University of Santiago de Compostela (USC), Santiago de Compostela 15706, Spain; Molecular Imaging Biomarkers Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela (USC), Santiago de Compostela 15706, Spain; Nuclear Medicine Department and Molecular Imaging Group, Health Research Institute of Santiago de Compostela (IDIS), SERGAS, Santiago de Compostela 15706, Spain.

José Ramón Caeiro (JR)

Department of Orthopaedic Surgery and Traumatology, Clinical University Hospital of Santiago de Compostela (CHUS), University of Santiago de Compostela (USC), Santiago de Compostela 15706, Spain.

Paula Carpintero-Fernandez (P)

CellCOM Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), A Coruña, Spain.

María D Mayán (MD)

CellCOM Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), A Coruña, Spain.

Pablo Aguiar (P)

Molecular Imaging Biomarkers Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela (USC), Santiago de Compostela 15706, Spain; Nuclear Medicine Department and Molecular Imaging Group, Health Research Institute of Santiago de Compostela (IDIS), SERGAS, Santiago de Compostela 15706, Spain. Electronic address: pablo.aguiar@usc.es.

María de la Fuente (M)

Nano-Oncology and Translational Therapeutics Group, Health Research Institute of Santiago de Compostela (IDIS), SERGAS, Santiago de Compostela 15706, Spain; University of Santiago de Compostela (USC), Santiago de Compostela 15706, Spain; Biomedical Research Networking Center on Oncology (CIBERONC), Madrid 28029, Spain; DIVERSA Technologies SL, Edificio Emprendia, Campus Vida Universidad de Santiago de Compostela 15782, Spain. Electronic address: maria.fuente.freire@sergas.es.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Quantitative PET tracking of intra-articularly...
questionsmedicales.fr › Eucaryotes › Animaux › Quantitative PET tracking of intra-articularly...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Quantitative PET tracking of intra-articularly...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Sénothérapie › Quantitative PET tracking of intra-articularly...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Acides hydroxamiques › Déferoxamine › Quantitative PET tracking of intra-articularly...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Quantitative PET tracking of intra-articularly...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Quantitative PET tracking of intra-articularly...
questionsmedicales.fr › Lipides › Quantitative PET tracking of intra-articularly...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Quantitative PET tracking of intra-articularly...