BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α


Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
13 04 2023
Historique:
medline: 14 4 2023
pubmed: 19 3 2023
entrez: 18 3 2023
Statut: ppublish

Résumé

After acute myocardial infarction, early reperfusion is the most effective strategy for reducing cardiac damage and improving clinical outcome. However, restoring blood flow to the ischemic myocardium can paradoxically induce injury by itself (reperfusion injury), with microvascular dysfunction being one contributing factor. α

Identifiants

pubmed: 36932954
doi: 10.1021/acs.jmedchem.2c01690
pmc: PMC10108358
doi:

Substances chimiques

Adrenergic Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4659-4670

Références

J Am Coll Cardiol. 2001 May;37(6):1516-22
pubmed: 11345359
Neuroscience. 2016 Dec 17;339:608-621
pubmed: 27751959
Am J Physiol Regul Integr Comp Physiol. 2002 Aug;283(2):R287-95
pubmed: 12121839
Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):475-82
pubmed: 20857090
Circulation. 1999 Feb 2;99(4):482-90
pubmed: 9927393
Trends Pharmacol Sci. 2015 Sep;36(9):605-16
pubmed: 26148636
Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):422-8
pubmed: 1979425
Eur Heart J. 2013 Jun;34(23):1714-22
pubmed: 23536610
Heart. 2009 Apr;95(7):603-8
pubmed: 19286902
J Am Coll Cardiol. 2003 Jan 15;41(2):190-4
pubmed: 12535806
Circ Res. 1999 Nov 12;85(10):965-9
pubmed: 10559144
Circ Res. 2016 May 13;118(10):1643-58
pubmed: 27174955
Sci Rep. 2020 Sep 21;10(1):15383
pubmed: 32958803
Circ Res. 1998 Jun 29;82(12):1312-22
pubmed: 9648728
Circ Res. 2019 Jul 5;125(2):245-258
pubmed: 31268854
Circulation. 1990 Jan;81(1):1-13
pubmed: 1967557
Microcirculation. 2017 Jan;24(1):
pubmed: 27976459
Am Heart J. 2009 Oct;158(4):615-21
pubmed: 19781422
J Am Coll Cardiol. 2003 Jan 15;41(2):195-6
pubmed: 12535807
J Med Chem. 2007 Dec 27;50(26):6665-72
pubmed: 18052022
J Cardiovasc Pharmacol. 1984 Sep-Oct;6(5):961-8
pubmed: 6209507
Circ Res. 1983 Jul;53(1):8-15
pubmed: 6861299
Clin Sci (Lond). 2002 Nov;103(5):517-24
pubmed: 12401126
J Biol Chem. 2001 Feb 16;276(7):4917-22
pubmed: 11056163
Nat Rev Cardiol. 2020 Dec;17(12):773-789
pubmed: 32620851
Eur Heart J. 2017 Nov 01;38(41):3056-3065
pubmed: 29020314
Basic Res Cardiol. 2019 Oct 15;114(6):45
pubmed: 31617010
Clin Cardiol. 2007 Jul;30(7):326-30
pubmed: 17674373
Circulation. 1999 Apr 27;99(16):2090-7
pubmed: 10217647
Circ Res. 1988 Mar;62(3):436-42
pubmed: 2893669
Clin Sci (Lond). 2003 May;104(5):509-20
pubmed: 12519093
Cell Commun Signal. 2011 Feb 07;9(1):5
pubmed: 21299895
J Med Chem. 2021 Jun 24;64(12):8545-8563
pubmed: 34110134
Eur J Pharmacol. 1982 Aug 27;82(3-4):199-202
pubmed: 6290236
Circulation. 1989 Apr;79(4):797-809
pubmed: 2564323
Circulation. 1992 Oct;86(4):1116-24
pubmed: 1356656
Circulation. 2000 Jun 6;101(22):2645-50
pubmed: 10840018
Nat Rev Cardiol. 2021 Dec;18(12):838-852
pubmed: 34234310
Circulation. 2000 Feb 15;101(6):689-94
pubmed: 10673263
Circulation. 2002 Dec 3;106(23):2901-7
pubmed: 12460869
Science. 1996 Aug 9;273(5276):803-5
pubmed: 8670422
Nat Rev Cardiol. 2022 Apr;19(4):265-280
pubmed: 34785770
Circulation. 1993 Apr;87(4):1264-74
pubmed: 8384938
J Am Coll Cardiol. 2010 Mar 23;55(12):1278
pubmed: 20298937

Auteurs

Daniel Meibom (D)

Bayer AG, 42113 Wuppertal, Germany.

Jutta Meyer (J)

Bayer AG, 42113 Wuppertal, Germany.

Clemens-Jeremias von Buehler (CJ)

Bayer AG, 42113 Wuppertal, Germany.

Karl D Collins (KD)

Bayer AG, 42113 Wuppertal, Germany.

Stefanie Maassen (S)

Bayer AG, 42113 Wuppertal, Germany.

Kersten Matthias Gericke (KM)

Bayer AG, 42113 Wuppertal, Germany.

Jörg Hüser (J)

Bayer AG, 42113 Wuppertal, Germany.

Joachim Mittendorf (J)

Bayer AG, 42113 Wuppertal, Germany.

Nuria Ortega Hernandez (N)

Bayer AG, 42113 Wuppertal, Germany.

Jens Schamberger (J)

Bayer AG, 42113 Wuppertal, Germany.

Jan Stampfuss (J)

Bayer AG, 42113 Wuppertal, Germany.

Alexander Straub (A)

Bayer AG, 42113 Wuppertal, Germany.

Afra Torge (A)

Bayer AG, 42113 Wuppertal, Germany.

Norbert Witowski (N)

Bayer AG, 42113 Wuppertal, Germany.

Frank Wunder (F)

Bayer AG, 42113 Wuppertal, Germany.

Articles similaires

Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH