Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
18 03 2023
18 03 2023
Historique:
received:
01
02
2023
accepted:
06
03
2023
entrez:
19
3
2023
pubmed:
20
3
2023
medline:
22
3
2023
Statut:
epublish
Résumé
Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enabling the identification of common bacterial targets for therapeutic intervention, we applied a standardized genomic, transcriptomic, proteomic and metabolomic technological framework to multiple clinical isolates of four sepsis-causing pathogens: Escherichia coli, Klebsiella pneumoniae species complex, Staphylococcus aureus and Streptococcus pyogenes. Exposure to human serum generated a sepsis molecular signature containing global increases in fatty acid and lipid biosynthesis and metabolism, consistent with cell envelope remodelling and nutrient adaptation for osmoprotection. In addition, acquisition of cholesterol was identified across the bacterial species. This detailed reference dataset has been established as an open resource to support discovery and translational research.
Identifiants
pubmed: 36934086
doi: 10.1038/s41467-023-37200-w
pii: 10.1038/s41467-023-37200-w
pmc: PMC10024524
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1530Subventions
Organisme : NIAID NIH HHS
ID : R01 AI173689
Pays : United States
Informations de copyright
© 2023. The Author(s).
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