Antibodies against Noncatalytic B Subunit of Factor XIII Inhibit Activation of Factor XIII and Fibrin Crosslinking.
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
medline:
29
8
2023
pubmed:
20
3
2023
entrez:
19
3
2023
Statut:
ppublish
Résumé
Coagulation factor XIII (FXIII) is a proenzyme of plasma transglutaminase. It comprises two catalytic A subunits (FXIII-A) and two carrier B subunits (FXIII-B). We previously reported that alloantibodies against FXIII-B could promote FXIII clearance in a patient with congenital FXIII-B deficiency who had received infusions of plasma-derived human FXIII (A We aimed to investigate whether anti-FXIII-B antibodies affect the catalytic function of FXIII. FXIII activation and fibrin crosslinking were examined in the presence of patient plasma, isolated patient IgG, or rat anti-FXIII-B monoclonal antibodies. Alloantibody levels were increased by repeated infusions of plasma-derived A Anti-FXIII-B antibodies binding to the A
Sections du résumé
BACKGROUND
BACKGROUND
Coagulation factor XIII (FXIII) is a proenzyme of plasma transglutaminase. It comprises two catalytic A subunits (FXIII-A) and two carrier B subunits (FXIII-B). We previously reported that alloantibodies against FXIII-B could promote FXIII clearance in a patient with congenital FXIII-B deficiency who had received infusions of plasma-derived human FXIII (A
OBJECTIVES
OBJECTIVE
We aimed to investigate whether anti-FXIII-B antibodies affect the catalytic function of FXIII.
METHODS
METHODS
FXIII activation and fibrin crosslinking were examined in the presence of patient plasma, isolated patient IgG, or rat anti-FXIII-B monoclonal antibodies.
RESULTS
RESULTS
Alloantibody levels were increased by repeated infusions of plasma-derived A
CONCLUSION
CONCLUSIONS
Anti-FXIII-B antibodies binding to the A
Substances chimiques
Factor XIII
9013-56-3
Fibrin
9001-31-4
Isoantibodies
0
Factor XIIIa
EC 2.3.2.13
Antibodies, Monoclonal
0
Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
841-854Subventions
Organisme : Japanese Ministry of Health, Labor, and Welfare
ID : 21FC1008
Organisme : Japan Agency for Medical Research and Development
ID : JP16ek0109043
Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
None declared.