Mfge8 is expressed by pericytes in gastric antrum submucosa from patients with obesity.
Mfge8
gastric emptying
gastric submucosa
microcirculation
pericytes
Journal
American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225
Informations de publication
Date de publication:
01 05 2023
01 05 2023
Historique:
pmc-release:
01
05
2024
medline:
18
4
2023
pubmed:
21
3
2023
entrez:
20
3
2023
Statut:
ppublish
Résumé
The main function of the stomach is to digest ingested food. Gastric antrum muscular contractions mix ingested food with digestive enzymes and stomach acid and propel the chyme through the pyloric sphincter at a rate in which the small intestine can process the chyme for optimal nutrient absorption. Mfge8 binding to α8β1 integrins helps regulate gastric emptying by reducing the force of antral smooth muscle contractions. The source of Mfge8 within gastric muscles is unclear. Since Mfge8 is a secreted protein, Mfge8 could be delivered via the circulation, or be locally secreted by cells within the muscle layers. In this study, we identify a source of Mfge8 within human gastric antrum muscles using spatial transcriptomic analysis. We show that Mfge8 is expressed in subpopulations of Mef2c
Identifiants
pubmed: 36939201
doi: 10.1152/ajpcell.00043.2023
pmc: PMC10110711
doi:
Substances chimiques
Receptor, Platelet-Derived Growth Factor beta
EC 2.7.10.1
Integrins
0
MFGE8 protein, human
0
Antigens, Surface
0
Milk Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
C992-C1006Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK129528
Pays : United States
Références
Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2024-34
pubmed: 21737783
Neurogastroenterol Motil. 2013 Sep;25(9):e609-20
pubmed: 23809506
J Physiol. 1999 Jul 1;518(Pt 1):257-69
pubmed: 10373707
Mol Biol Rep. 2022 Sep;49(9):8883-8893
pubmed: 35581508
J Cell Biochem. 2009 Apr 15;106(6):957-66
pubmed: 19204935
Histol Histopathol. 2009 Jul;24(7):909-69
pubmed: 19475537
Am J Physiol. 1989 Jul;257(1 Pt 1):G111-7
pubmed: 2750901
FASEB J. 2018 May 15;:fj201800109R
pubmed: 29763381
J Vasc Res. 2014;51(3):163-74
pubmed: 24853910
Mediators Inflamm. 2016;2016:5628486
pubmed: 27429513
Nucleic Acids Res. 1989 Feb 25;17(4):1767
pubmed: 2701935
Neurogastroenterol Motil. 2001 Jun;13(3):187-98
pubmed: 11437981
Elife. 2018 Mar 21;7:
pubmed: 29561727
J Neurogastroenterol Motil. 2014 Jul 31;20(3):294-317
pubmed: 24948131
Nature. 1995 Jan 26;373(6512):347-9
pubmed: 7530333
Pediatr Surg Int. 2015 Nov;31(11):1077-85
pubmed: 26276426
Curr Dir Autoimmun. 2006;9:162-72
pubmed: 16394660
Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):27022-27033
pubmed: 33051294
Nat Rev Gastroenterol Hepatol. 2016 Jul;13(7):389-401
pubmed: 27251213
Gut. 1969 Jul;10(7):543-8
pubmed: 5806934
Vascul Pharmacol. 2018 Feb;101:21-28
pubmed: 29169950
J Physiol. 2011 Dec 15;589(Pt 24):6105-18
pubmed: 22005683
Gut. 2015 Oct;64(10):1650-68
pubmed: 26342014
Front Cardiovasc Med. 2022 Jun 01;9:876591
pubmed: 35722109
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):660-5
pubmed: 23269839
Adv Exp Med Biol. 2022;1383:229-241
pubmed: 36587162
Circ Res. 1996 Feb;78(2):196-204
pubmed: 8575062
Cell Motil Cytoskeleton. 2002 Dec;53(4):293-316
pubmed: 12378540
Apoptosis. 2011 Nov;16(11):1077-86
pubmed: 21901532
J Biol Chem. 2012 Mar 9;287(11):8361-70
pubmed: 22275376
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Am J Physiol. 1976 Mar;230(3):583-9
pubmed: 1266961
J Diabetes Res. 2018 May 31;2018:8743874
pubmed: 29955616
Annu Rev Physiol. 1982;44:29-42
pubmed: 7041797
Curr Vasc Pharmacol. 2013 Sep;11(5):768-76
pubmed: 22272902
Neurogastroenterol Motil. 2019 Apr;31(4):e13546
pubmed: 30740834
J Cell Biol. 1970 Oct;47(1):183-96
pubmed: 4327514
PLoS One. 2017 Apr 20;12(4):e0176031
pubmed: 28426719
Dev Cell. 2011 Aug 16;21(2):193-215
pubmed: 21839917
J Muscle Res Cell Motil. 2021 Jun;42(2):219-231
pubmed: 34085177
J Physiol. 2003 Aug 1;550(Pt 3):829-44
pubmed: 12844505
Am J Pathol. 2014 Jul;184(7):1981-90
pubmed: 24838098
Front Cell Dev Biol. 2020 Feb 14;8:77
pubmed: 32117997
J Physiol. 1999 Jan 15;514 ( Pt 2):515-31
pubmed: 9852332
Curr Treat Options Gastroenterol. 2017 Dec;15(4):441-459
pubmed: 28879488
Nutrients. 2018 Feb 28;10(3):
pubmed: 29495569
Gastroenterology. 2022 Jan;162(1):109-121.e5
pubmed: 34624355
Placenta. 2018 Jan;61:39-47
pubmed: 29277270
Nat Neurosci. 2021 May;24(5):633-645
pubmed: 33603231
Stem Cells Dev. 2019 Sep 15;28(18):1214-1223
pubmed: 31264500
J Physiol. 2011 Feb 1;589(Pt 3):697-710
pubmed: 21173079
Anal Biochem. 2019 Jul 15;577:1-13
pubmed: 30981700
Mol Biol Cell. 2005 Dec;16(12):5528-37
pubmed: 16195353
Gastroenterology. 1984 May;86(5 Pt 1):866-75
pubmed: 6706070
Expert Opin Ther Targets. 2013 Nov;17(11):1275-85
pubmed: 23972256
Adv Exp Med Biol. 2019;1124:3-46
pubmed: 31183821
Transfusion. 2008 Nov;48(11):2370-6
pubmed: 18647368
Elife. 2016 Apr 19;5:
pubmed: 27092791
Am J Physiol Endocrinol Metab. 2014 Sep 15;307(6):E494-502
pubmed: 25074985
Mol Cell Biol. 1988 Dec;8(12):5224-31
pubmed: 3244353
J Physiol. 1994 Oct 1;480 ( Pt 1):91-7
pubmed: 7853230
Physiol Rev. 2014 Jul;94(3):859-907
pubmed: 24987007
Baillieres Clin Gastroenterol. 1991 Jun;5(2):371-407
pubmed: 1912656
Histol Histopathol. 2021 Jun;36(6):633-643
pubmed: 33595091