Alcohol Craving and Severity are Associated with Dorsal Anterior Cingulate Choline Levels in Individuals with an Alcohol Use Disorder.
Journal
Alcohol and alcoholism (Oxford, Oxfordshire)
ISSN: 1464-3502
Titre abrégé: Alcohol Alcohol
Pays: England
ID NLM: 8310684
Informations de publication
Date de publication:
09 May 2023
09 May 2023
Historique:
received:
18
11
2022
revised:
27
01
2023
accepted:
01
03
2023
medline:
11
5
2023
pubmed:
21
3
2023
entrez:
20
3
2023
Statut:
ppublish
Résumé
Magnetic resonance spectroscopy (MRS) has been used to probe inflammation in the brain. While altered MRS metabolite levels have previously been found in individuals with alcohol use disorder (AUD), the relationship between potential metabolite markers of inflammation and the clinical correlates of AUD remains understudied. Therefore, this exploratory study sought to elucidate the clinical significance of inflammation in AUD by examining relationships between metabolites, AUD severity, alcohol consumption, and craving in individuals with AUD. Data for this secondary analysis are derived from a two-week clinical trial of ibudilast to treat AUD. Forty-three non-treatment-seeking individuals with an AUD (26M/17F) completed an MRS scan and alcohol-related questionnaires. MRS was performed using a multi-voxel array placed above the corpus callosum, extending from the pregnenual anterior cingulate to premotor cortex. The dorsal anterior cingulate was selected as the volume of interest. Metabolite levels of choline-compounds (Cho), myo-inositol (mI), and creatine+phosphocreatine (Cr) were quantified. Separate hierarchical regression models were used to evaluate the independent effects of metabolite levels on alcohol craving, alcohol problem severity, and alcohol consumption. Dorsal anterior cingulate Cho predicted alcohol craving and alcohol problem severity over and above demographics, medication, and alcohol consumption measures. mI and Cr did not predict alcohol craving or alcohol problem severity. Metabolite markers were not predictive of alcohol consumption. This preliminary study indicates that dACC Cho is sensitive to clinical characteristics of AUD. This is a further step in advancing neurometabolites, particularly Cho, as potential biomarkers and treatment targets for AUD.
Identifiants
pubmed: 36939375
pii: 7080944
doi: 10.1093/alcalc/agad014
pmc: PMC10168708
doi:
Substances chimiques
Choline
N91BDP6H0X
Ethanol
3K9958V90M
Inositol
4L6452S749
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
289-297Subventions
Organisme : NIDA NIH HHS
ID : P50 DA005010
Pays : United States
Organisme : NIAAA NIH HHS
ID : K24 AA025704
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA029712
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA005010-33
Pays : United States
Organisme : NIAAA NIH HHS
ID : K24AA025704
Pays : United States
Organisme : NIAAA NIH HHS
ID : F32 AA027699
Pays : United States
Organisme : NIAAA NIH HHS
ID : F31 AA028976
Pays : United States
Informations de copyright
© The Author(s) 2023. Medical Council on Alcohol and Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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