Impact of pharmacological interventions on intrapulmonary shunt during one-lung ventilation in adult thoracic surgery: a systematic review and component network meta-analysis.
intrapulmonary shunt
meta-analysis
one-lung ventilation
oxygenation
thoracic surgery
Journal
British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
24
05
2022
revised:
05
08
2022
accepted:
24
08
2022
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
23
3
2023
Statut:
ppublish
Résumé
Intrapulmonary shunt is a major determinant of oxygenation in thoracic surgery under one-lung ventilation. We reviewed the effects of available treatments on shunt, Pao Online databases were searched for RCTs comparing pharmacological interventions and intrapulmonary shunt in thoracic surgery under one-lung ventilation up to March 30, 2022. Random-effects (component) network meta-analysis compared 24 treatments and 19 treatment components. The Confidence in Network Meta-Analysis (CINeMA) framework assessed evidence certainty. The primary outcome was intrapulmonary shunt fraction during one-lung ventilation. A total of 55 RCTs were eligible for systematic review (2788 participants). The addition of N Adding N PROSPERO CRD42022310313.
Sections du résumé
BACKGROUND
Intrapulmonary shunt is a major determinant of oxygenation in thoracic surgery under one-lung ventilation. We reviewed the effects of available treatments on shunt, Pao
METHODS
Online databases were searched for RCTs comparing pharmacological interventions and intrapulmonary shunt in thoracic surgery under one-lung ventilation up to March 30, 2022. Random-effects (component) network meta-analysis compared 24 treatments and 19 treatment components. The Confidence in Network Meta-Analysis (CINeMA) framework assessed evidence certainty. The primary outcome was intrapulmonary shunt fraction during one-lung ventilation.
RESULTS
A total of 55 RCTs were eligible for systematic review (2788 participants). The addition of N
CONCLUSIONS
Adding N
SYSTEMATIC REVIEW PROTOCOL
PROSPERO CRD42022310313.
Identifiants
pubmed: 36939497
pii: S0007-0912(22)00516-5
doi: 10.1016/j.bja.2022.08.039
pii:
doi:
Substances chimiques
Almitrine
9A1222NBG4
Iloprost
JED5K35YGL
Propofol
YI7VU623SF
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e92-e105Informations de copyright
Copyright © 2022 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declarations of interest AH has received speaker fees from Medtronic International (Sàrl, Tolochenaz, Switzerland) regarding an unrelated topic. The other authors have no direct or indirect conflict of interest to report.