[From the first kidney transplants to the current pediatric kidney transplant].
Des premières transplantations rénales à la transplantation rénale pédiatrique actuelle.
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
entrez:
21
3
2023
pubmed:
22
3
2023
medline:
24
3
2023
Statut:
ppublish
Résumé
Kidney transplantation is the preferred treatment for end-stage renal failure in children but remains a rare procedure with only 100 to 120 pediatric kidney transplants per year in France. Although the main principles of kidney transplantation are the same in children and adults, some specificities regarding underlying kidney diseases, surgical technique, immunosuppressive drugs metabolism and the risk of infectious complications require a specific expertise to care for these patients. Similarly, the major morbidity of dialysis in children and the need for repeated transplants during the patient's life justify pediatric specificities in the choice of donors and the allocation of grafts in most kidney allocation systems worldwide. The objectives of this review are to present the history and specificities of pediatric kidney transplantation, to describe the current activity in France and to discuss future developments while emphasizing the need for basic and clinical research focused on the pediatric population. Des premières transplantations rénales à la transplantation rénale pédiatrique actuelle. La transplantation rénale est le traitement de choix de l’insuffisance rénale terminale chez l’enfant, mais cela reste une procédure rare avec, en France, seulement 100 à 120 transplantations rénales pédiatriques par an. Si les grands principes de la transplantation rénale sont identiques chez l’enfant et chez l’adulte, certaines spécificités en lien avec les maladies rénales sous-jacentes, la technique chirurgicale, le métabolisme des immunosuppresseurs et le risque de complication infectieuse, justifient une prise en charge particulière des jeunes patients. La morbidité de la dialyse, particulière chez l’enfant, et le besoin de transplantations répétées au cours de la vie du patient expliquent des spécificités pédiatriques dans le choix des donneurs et l’allocation des greffons sur la liste d’attente nationale. L’objectif de cette revue est de présenter l’histoire et les spécificités de la transplantation rénale pédiatrique, de décrire l’état actuel de cette activité en France et d’évoquer les perspectives futures en soulignant le besoin de recherches fondamentale et clinique focalisées sur la population pédiatrique.
Autres résumés
Type: Publisher
(fre)
Des premières transplantations rénales à la transplantation rénale pédiatrique actuelle.
Identifiants
pubmed: 36943126
doi: 10.1051/medsci/2023035
pii: msc230051
doi:
Substances chimiques
Immunosuppressive Agents
0
Types de publication
Review
English Abstract
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
281-286Informations de copyright
© 2023 médecine/sciences – Inserm.
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