Dendritic cell subsets in cancer immunity and tumor antigen sensing.
Dendritic cell subsets
Immune cell death
Innate immune sensing
Migration
Tumor microenvironment
Tumor-derived extracellular vesicles
Journal
Cellular & molecular immunology
ISSN: 2042-0226
Titre abrégé: Cell Mol Immunol
Pays: China
ID NLM: 101242872
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
11
11
2022
accepted:
14
02
2023
medline:
24
5
2023
pubmed:
24
3
2023
entrez:
23
3
2023
Statut:
ppublish
Résumé
Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles in both innate and adaptive immune responses. Due to their ability to cross-present tumor cell-associated antigens to naïve T cells, DCs are instrumental in the generation of specific T-cell-mediated antitumor effector responses in the control of tumor growth and tumor cell dissemination. Within an immunosuppressive tumor microenvironment, DC antitumor functions can, however, be severely impaired. In this review, we focus on the mechanisms of DC capture and activation by tumor cell antigens and the role of the tumor microenvironment in shaping DC functions, taking advantage of recent studies showing the phenotype acquisition, transcriptional state and functional programs revealed by scRNA-seq analysis. The therapeutic potential of DC-mediated tumor antigen sensing in priming antitumor immunity is also discussed.
Identifiants
pubmed: 36949244
doi: 10.1038/s41423-023-00990-6
pii: 10.1038/s41423-023-00990-6
pmc: PMC10203372
doi:
Substances chimiques
Antigens, Neoplasm
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
432-447Informations de copyright
© 2023. The Author(s).
Références
Sci Immunol. 2022 Apr;7(70):eabm9409
pubmed: 35363544
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6128-33
pubmed: 15073331
Clin Immunol. 2007 Nov;125(2):184-93
pubmed: 17827069
Trends Immunol. 2016 Mar;37(3):193-207
pubmed: 26839260
Nat Commun. 2011 Nov 01;2:521
pubmed: 22045000
J Immunol. 2016 Apr 1;196(7):3191-8
pubmed: 26927800
Oncotarget. 2017 Sep 11;9(2):2887-2894
pubmed: 29416821
Cell Rep. 2015 May 19;11(7):1018-30
pubmed: 25959818
Nat Med. 2014 Nov;20(11):1301-9
pubmed: 25344738
Clin Cancer Res. 2018 Oct 15;24(20):4937-4948
pubmed: 29950349
Cancer Cell. 2017 May 8;31(5):711-723.e4
pubmed: 28486109
Nat Rev Immunol. 2020 Jan;20(1):7-24
pubmed: 31467405
J Immunother Cancer. 2017 Apr 18;5:32
pubmed: 28428881
Nat Med. 2016 Jun;22(6):624-31
pubmed: 27135741
Cancer Immunol Res. 2013 Dec;1(6):402-15
pubmed: 24778133
PLoS One. 2016 Nov 4;11(11):e0165681
pubmed: 27814372
J Immunol. 2009 Apr 15;182(8):4616-23
pubmed: 19342636
Nat Med. 2007 Jan;13(1):54-61
pubmed: 17187072
J Immunother Cancer. 2020 Mar;8(1):
pubmed: 32209603
Front Immunol. 2022 Feb 22;13:828319
pubmed: 35273608
Oncoimmunology. 2015 Mar 2;4(4):e1008866
pubmed: 26137404
Science. 2015 Nov 20;350(6263):972-8
pubmed: 26516201
Nat Commun. 2016 Dec 23;7:13720
pubmed: 28008905
Mediators Inflamm. 2016;2016:5678046
pubmed: 27630451
J Immunol. 2010 Feb 1;184(3):1261-7
pubmed: 20026742
J Exp Clin Cancer Res. 2022 Apr 23;41(1):155
pubmed: 35459193
Science. 2017 Jun 9;356(6342):
pubmed: 28473638
Cell Death Dis. 2020 Oct 22;11(10):896
pubmed: 33093453
J Immunol. 2021 Nov 1;207(9):2374-2384
pubmed: 34588222
Immunol Cell Biol. 2018 Nov;96(10):1131-1139
pubmed: 29920767
Immunol Rev. 2019 Jul;290(1):24-38
pubmed: 31355488
Cancer Res. 2018 Jun 1;78(11):3014-3026
pubmed: 29523540
Nat Med. 2018 Aug;24(8):1178-1191
pubmed: 29942093
J Immunol. 2004 Nov 1;173(9):5749-56
pubmed: 15494527
Cancer Res. 2011 Aug 15;71(16):5423-34
pubmed: 21697280
Oncotarget. 2019 Feb 15;10(14):1399-1406
pubmed: 30858925
Lancet. 2002 Jul 27;360(9329):295-305
pubmed: 12147373
Cancer Immunol Res. 2019 Apr;7(4):584-599
pubmed: 30808680
Cell Rep. 2022 Jun 7;39(10):110914
pubmed: 35675777
Cancer Res. 2016 Apr 15;76(8):2076-81
pubmed: 26964621
Immunol Lett. 2018 Jul;199:36-43
pubmed: 29800589
J Exp Med. 2011 Sep 26;208(10):1989-2003
pubmed: 21930769
Eur J Immunol. 2022 Nov;52(11):1759-1767
pubmed: 35187651
Nat Rev Immunol. 2020 Feb;20(2):95-112
pubmed: 31558839
Annu Rev Immunol. 2013;31:563-604
pubmed: 23516985
iScience. 2021 Apr 14;24(5):102424
pubmed: 33997702
Immunity. 2019 Sep 17;51(3):573-589.e8
pubmed: 31474513
Front Immunol. 2021 Dec 17;12:787116
pubmed: 34975880
Blood. 2002 May 1;99(9):3263-71
pubmed: 11964292
Cancer Immunol Res. 2015 Sep;3(9):1082-95
pubmed: 26041736
Mol Immunol. 2010 May;47(9):1765-73
pubmed: 20347150
J Clin Invest. 2010 Feb;120(2):457-71
pubmed: 20093776
Cell. 2021 Feb 4;184(3):792-809.e23
pubmed: 33545035
Nat Rev Immunol. 2017 Apr;17(4):262-275
pubmed: 28287107
J Immunol. 2012 Apr 15;188(8):3869-75
pubmed: 22427644
J Immunother Cancer. 2019 Oct 16;7(1):260
pubmed: 31619293
J Clin Invest. 2020 Jul 1;130(7):3528-3542
pubmed: 32182225
J Immunother Cancer. 2022 Jan;10(1):
pubmed: 34987021
Nat Commun. 2019 Jul 5;10(1):3000
pubmed: 31278254
Immunity. 2013 May 23;38(5):970-83
pubmed: 23706669
Nat Rev Cancer. 2021 May;21(5):298-312
pubmed: 33750922
J Immunol. 1998 Aug 15;161(4):1947-53
pubmed: 9712065
Cancer Cell. 2016 Aug 8;30(2):324-336
pubmed: 27424807
Immunity. 2014 Nov 20;41(5):843-52
pubmed: 25517616
J Leukoc Biol. 2000 May;67(5):607-14
pubmed: 10810999
Front Immunol. 2018 Apr 27;9:744
pubmed: 29755453
Immunity. 2007 Sep;27(3):419-21
pubmed: 17892851
EMBO J. 2018 Jul 2;37(13):
pubmed: 29807932
Nat Med. 2004 Sep;10(9):950-8
pubmed: 15334073
Cell Death Dis. 2020 Nov 26;11(11):1013
pubmed: 33243969
Sci Transl Med. 2020 Mar 11;12(534):
pubmed: 32161104
Trends Immunol. 2007 Sep;28(9):385-92
pubmed: 17692569
Nat Rev Immunol. 2022 Feb;22(2):67-68
pubmed: 35027741
Eur J Immunol. 2014 Jul;44(7):1896-903
pubmed: 24777958
Nat Med. 2010 Aug;16(8):880-6
pubmed: 20622859
Cancers (Basel). 2021 Oct 07;13(19):
pubmed: 34638505
Cell. 2019 Oct 31;179(4):829-845.e20
pubmed: 31675496
Science. 2017 Apr 21;356(6335):
pubmed: 28428369
Semin Immunopathol. 2018 Sep;40(5):477-490
pubmed: 29594331
Nat Rev Cancer. 2009 Jan;9(1):57-63
pubmed: 19052556
Immunity. 2009 Aug 21;31(2):232-44
pubmed: 19699172
Nat Med. 2009 Oct;15(10):1170-8
pubmed: 19767732
Nat Commun. 2017 Jul 17;8:16073
pubmed: 28714465
Oncoimmunology. 2014 Apr 25;3:e28518
pubmed: 25071979
Cancer Res. 2004 Aug 15;64(16):5535-8
pubmed: 15313886
J Exp Med. 2011 Sep 26;208(10):2005-16
pubmed: 21930765
Nat Commun. 2014 Oct 10;5:5166
pubmed: 25300616
Annu Rev Immunol. 2021 Apr 26;39:131-166
pubmed: 33481643
Nat Rev Immunol. 2015 Aug;15(8):471-85
pubmed: 26160613
Nat Rev Mol Cell Biol. 2020 Sep;21(9):501-521
pubmed: 32424334
Nat Rev Immunol. 2017 Feb;17(2):97-111
pubmed: 27748397
Oncoimmunology. 2019 Sep 30;8(12):e1667742
pubmed: 31741769
J Natl Cancer Inst. 2016 Oct 5;109(1):
pubmed: 27707838
Immunity. 2017 Feb 21;46(2):205-219
pubmed: 28190711
J Immunol. 1997 Nov 15;159(10):4772-80
pubmed: 9366401
Nature. 2020 Aug;584(7822):624-629
pubmed: 32788723
Cell Rep. 2015 Dec 29;13(12):2851-64
pubmed: 26711349
Nat Immunol. 2014 Jul;15(7):623-30
pubmed: 24813163
Front Oncol. 2021 Oct 01;11:743050
pubmed: 34660305
J Immunol. 2013 Jan 15;190(2):812-20
pubmed: 23248265
Sci Adv. 2021 Feb 3;7(6):
pubmed: 33536205
Semin Immunol. 2021 Feb;52:101481
pubmed: 34023170
Immunity. 2011 May 27;34(5):651-64
pubmed: 21616435
Cell. 2017 Jun 29;170(1):127-141.e15
pubmed: 28666115
Annu Rev Immunol. 2013;31:51-72
pubmed: 23157435
Mol Cancer. 2020 Nov 12;19(1):160
pubmed: 33183286
Oncotarget. 2016 Jun 28;7(26):39256-39269
pubmed: 27256980
Int J Cancer. 2015 Feb 15;136(4):E74-84
pubmed: 25066479
Front Immunol. 2018 Mar 14;9:496
pubmed: 29593736
Trends Cell Biol. 2015 Jun;25(6):364-72
pubmed: 25683921
Nat Commun. 2021 Apr 14;12(1):2237
pubmed: 33854047
Cancer Immunol Res. 2014 Dec;2(12):1199-208
pubmed: 25300859
J Extracell Vesicles. 2017 Sep 3;6(1):1368823
pubmed: 28959385
Cell. 2020 Jul 23;182(2):497-514.e22
pubmed: 32579974
BMC Cancer. 2015 Dec 24;15:1009
pubmed: 26704308
Cancer Res. 2008 Feb 1;68(3):627-30
pubmed: 18245459
Cell Res. 2020 Sep;30(9):745-762
pubmed: 32561858
Front Immunol. 2019 May 29;10:1222
pubmed: 31191558
J Immunol. 2000 Oct 1;165(7):3797-803
pubmed: 11034385
Science. 2020 Feb 7;367(6478):
pubmed: 32029601
Cell Rep. 2016 Jun 14;15(11):2462-74
pubmed: 27264183
Front Immunol. 2019 Aug 07;10:1878
pubmed: 31440253
Science. 2008 Nov 14;322(5904):1097-100
pubmed: 19008445
J Exp Med. 2021 Jan 4;218(1):
pubmed: 33601412
Nat Immunol. 2018 Aug;19(8):885-897
pubmed: 30013147
Sci Rep. 2019 Oct 29;9(1):15527
pubmed: 31664180
Oncogene. 2010 Jan 28;29(4):482-91
pubmed: 19881547
Nat Rev Cancer. 2012 Dec;12(12):860-75
pubmed: 23151605
J Exp Med. 2021 Sep 6;218(9):
pubmed: 34325468
Cancer Res. 2013 Apr 15;73(8):2493-504
pubmed: 23418322
Oncogene. 2020 Apr;39(16):3292-3304
pubmed: 32071396
Immunity. 2011 May 27;34(5):637-50
pubmed: 21616434
Biochem Soc Trans. 2004 Aug;32(Pt 4):629-32
pubmed: 15270693
Cancer Cell. 2020 Jun 8;37(6):786-799.e5
pubmed: 32516589
Immunity. 2013 Apr 18;38(4):729-41
pubmed: 23562161
Cell. 2017 May 4;169(4):750-765.e17
pubmed: 28475900
J Immunol. 2007 Jun 1;178(11):6867-75
pubmed: 17513735
Nature. 1998 Mar 5;392(6671):86-9
pubmed: 9510252
Int J Cancer. 2015 Jul 15;137(2):345-58
pubmed: 25492101
Cancer Cell. 2014 Nov 10;26(5):638-52
pubmed: 25446897
Oncogene. 2015 Oct 8;34(41):5302-8
pubmed: 25639870
Immunity. 2020 Aug 18;53(2):335-352.e8
pubmed: 32610077
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23730-23741
pubmed: 32879009
Cancer. 2007 Nov 1;110(9):1911-28
pubmed: 17849470
Cancer Res. 2018 Apr 1;78(7):1685-1699
pubmed: 29363545
Curr Opin Immunol. 2018 Aug;53:180-186
pubmed: 29879585
Cancer. 1996 Mar 15;77(6):1101-6
pubmed: 8635130
Cell. 2019 Apr 18;177(3):556-571.e16
pubmed: 30955881
Immunity. 2014 Nov 20;41(5):830-42
pubmed: 25517615
J Immunol. 2005 Sep 1;175(5):2788-92
pubmed: 16116163
Int Immunol. 2009 Apr;21(4):317-37
pubmed: 19246554
J Immunol. 2013 May 15;190(10):5216-25
pubmed: 23585680
Nat Rev Immunol. 2021 Feb;21(2):101-115
pubmed: 32908299
Nat Med. 2007 Sep;13(9):1050-9
pubmed: 17704786
J Cell Biol. 2002 Sep 30;158(7):1277-85
pubmed: 12356871
Cell. 2015 Jun 18;161(7):1527-38
pubmed: 26073941
Blood. 1999 Dec 1;94(11):3791-9
pubmed: 10572093
Trends Immunol. 2018 Mar;39(3):209-221
pubmed: 29275092
Nature. 2009 Apr 16;458(7240):899-903
pubmed: 19219027
Genome Biol. 2018 Jan 29;19(1):10
pubmed: 29378643
Trends Cancer. 2018 Nov;4(11):784-792
pubmed: 30352680
Immunity. 2005 Nov;23(5):491-502
pubmed: 16286017
Blood. 2012 Oct 11;120(15):3001-6
pubmed: 22936665
Blood. 1998 Dec 1;92(11):4150-66
pubmed: 9834220
Immunity. 2013 Feb 21;38(2):336-48
pubmed: 23352235
Biochem Biophys Res Commun. 2005 Aug 19;334(1):193-198
pubmed: 16002046
Cell Mol Immunol. 2022 Jan;19(1):3-13
pubmed: 34480145
EMBO J. 2009 Mar 4;28(5):578-90
pubmed: 19165151
J Clin Invest. 2003 Mar;111(5):727-35
pubmed: 12618527
Immunity. 2020 Jan 14;52(1):183-199.e9
pubmed: 31924475
Cell. 2020 Apr 16;181(2):442-459.e29
pubmed: 32302573
Nat Immunol. 2012 Sep;13(9):832-42
pubmed: 22842346
Oncogene. 2016 Nov 17;35(46):5931-5941
pubmed: 27086930
J Immunother Cancer. 2019 Apr 8;7(1):100
pubmed: 30961656
J Immunol. 2014 Apr 15;192(8):3805-15
pubmed: 24646734
J Invest Dermatol. 2010 Jun;130(6):1646-56
pubmed: 20220766
Int Rev Cell Mol Biol. 2019;344:31-89
pubmed: 30798990
Immunol Lett. 2012 Nov-Dec;148(1):34-8
pubmed: 22898052
Cell Res. 2020 Aug;30(8):660-669
pubmed: 32467592
Nat Commun. 2020 Jun 2;11(1):2749
pubmed: 32488012
Cancer Res. 2019 Apr 15;79(8):1996-2008
pubmed: 30723115
Cancer Res. 2016 Apr 1;76(7):1746-56
pubmed: 26842877
Front Pharmacol. 2018 Aug 06;9:878
pubmed: 30127747
Immunity. 2020 Jun 16;52(6):1039-1056.e9
pubmed: 32392463
Nature. 2020 Apr;580(7802):257-262
pubmed: 32269339
Blood. 2012 Jun 21;119(25):6052-62
pubmed: 22442345
Annu Rev Immunol. 2010;28:367-88
pubmed: 20192808
Int J Mol Sci. 2020 May 30;21(11):
pubmed: 32486257
J Immunother Cancer. 2020 Jul;8(2):
pubmed: 32690667
Cancer Cell. 2014 Nov 10;26(5):623-37
pubmed: 25446896
Cancer Res. 2006 Sep 15;66(18):9290-8
pubmed: 16982774
Nat Rev Immunol. 2017 Sep;17(9):559-572
pubmed: 28555670
Curr Opin Immunol. 2015 Feb;32:21-7
pubmed: 25553393
Front Immunol. 2019 Feb 13;10:211
pubmed: 30814999
Immunity. 2016 Sep 20;45(3):669-684
pubmed: 27637149
Front Immunol. 2022 Mar 10;13:733800
pubmed: 35355992
Immunity. 2011 May 27;34(5):665-79
pubmed: 21616436
Nature. 2021 Jul;595(7865):101-106
pubmed: 34108686
Immunity. 2016 Apr 19;44(4):924-38
pubmed: 27096321
Nat Cancer. 2020 Jul;1(7):681-691
pubmed: 35122038
Cancer Med. 2022 Feb;11(4):922-930
pubmed: 34964283
Cell Death Dis. 2019 Aug 2;10(8):578
pubmed: 31371700
Nat Commun. 2017 Dec 14;8(1):2122
pubmed: 29242535
Nat Commun. 2019 Apr 2;10(1):1486
pubmed: 30940805
Cell Death Differ. 2014 Jan;21(1):15-25
pubmed: 23787994
Nature. 2002 Jul 11;418(6894):191-5
pubmed: 12110890
Immunity. 2021 Aug 10;54(8):1883-1900.e5
pubmed: 34331874
J Immunol. 2005 May 1;174(9):5490-8
pubmed: 15843547
Int J Cancer. 2014 Sep 1;135(5):1165-77
pubmed: 24500981
Cancer Discov. 2016 Jan;6(1):71-9
pubmed: 26493961
Cancer Immunol Immunother. 2004 Jun;53(6):543-50
pubmed: 14666382
J Clin Invest. 2019 Mar 1;129(3):1211-1228
pubmed: 30589644
Immunity. 2019 Jan 15;50(1):37-50
pubmed: 30650380
Immunity. 2011 May 27;34(5):680-92
pubmed: 21616437
Trends Immunol. 2020 Dec;41(12):1062-1071
pubmed: 33250080
Front Immunol. 2015 Aug 24;6:408
pubmed: 26379663
Eur J Immunol. 2022 Nov;52(11):1750-1758
pubmed: 35106759
J Exp Med. 2012 Mar 12;209(3):495-506
pubmed: 22351930
Cell Rep. 2020 Oct 20;33(3):108278
pubmed: 33086073
Immunity. 2020 Aug 18;53(2):353-370.e8
pubmed: 32735845
Nat Rev Clin Oncol. 2011 Mar;8(3):151-60
pubmed: 21364688
J Immunol. 2011 Nov 1;187(9):4411-5
pubmed: 21948982
Cancer Res. 2018 Dec 1;78(23):6643-6654
pubmed: 30297531
Immunity. 2021 Jun 8;54(6):1154-1167.e7
pubmed: 33979578
EMBO J. 2021 Jul 1;40(13):e108130
pubmed: 34121201
Clin Cancer Res. 2010 Jul 1;16(13):3409-19
pubmed: 20472682
J Immunother Cancer. 2020 Apr;8(1):
pubmed: 32241808
Nature. 2015 Jul 9;523(7559):231-5
pubmed: 25970248
J Immunother Cancer. 2020 Jul;8(2):
pubmed: 32737142
J Immunother Cancer. 2018 Oct 11;6(1):106
pubmed: 30314524
Eur J Immunol. 2019 Nov;49(11):1998-2011
pubmed: 31372985
Chem Immunol Allergy. 2014;99:89-104
pubmed: 24217604
JCI Insight. 2021 Sep 8;6(17):
pubmed: 34283809
Immunity. 2019 May 21;50(5):1317-1334.e10
pubmed: 30979687
J Immunol. 2014 Nov 15;193(10):4779-82
pubmed: 25320273
Oncogene. 2008 Jan 7;27(2):218-24
pubmed: 18176603
Cancer Immunol Immunother. 2012 Nov;61(11):2067-77
pubmed: 22552381
Cell. 2019 Oct 31;179(4):846-863.e24
pubmed: 31668803
Nat Med. 2021 Dec;27(12):2212-2223
pubmed: 34887574
Trends Immunol. 2015 Apr;36(4):250-6
pubmed: 25758021
J Hematol Oncol. 2019 Apr 1;12(1):35
pubmed: 30935414
Blood. 2004 Feb 15;103(4):1391-7
pubmed: 14551144
Annu Rev Immunol. 2012;30:1-22
pubmed: 22136168
Immunity. 2022 Mar 8;55(3):393-404
pubmed: 35263567
Annu Rev Immunol. 2001;19:47-64
pubmed: 11244030
Cell. 2018 Feb 22;172(5):1022-1037.e14
pubmed: 29429633
Cell. 2015 Sep 10;162(6):1257-70
pubmed: 26343581
Chempluschem. 2015 Aug;80(8):1267-1278
pubmed: 31973291
Cell. 2014 Jul 31;158(3):506-21
pubmed: 25083866
Biology (Basel). 2021 Sep 01;10(9):
pubmed: 34571733
Nat Immunol. 2021 May;22(5):560-570
pubmed: 33753940
J Dermatol Sci. 2016 Jul;83(1):3-9
pubmed: 27236509
Immunity. 2018 Dec 18;49(6):1148-1161.e7
pubmed: 30552023
Front Immunol. 2020 May 15;11:940
pubmed: 32499786
Clin Cancer Res. 2021 Aug 15;27(16):4574-4586
pubmed: 34112709