atherosclerosis clonal hematopoiesis sequencing somatic

Journal

Nature cardiovascular research
ISSN: 2731-0590
Titre abrégé: Nat Cardiovasc Res
Pays: England
ID NLM: 9918284280206676

Informations de publication

Date de publication:
16 Jan 2023
Historique:
entrez: 23 3 2023
pubmed: 24 3 2023
medline: 24 3 2023
Statut: ppublish

Résumé

Somatic mutations in blood indicative of clonal hematopoiesis of indeterminate potential (CHIP) are associated with an increased risk of hematologic malignancy, coronary artery disease, and all-cause mortality. Here we analyze the relation between CHIP status and incident peripheral artery disease (PAD) and atherosclerosis, using whole-exome sequencing and clinical data from the UK Biobank and Mass General Brigham Biobank. CHIP associated with incident PAD and atherosclerotic disease across multiple beds, with increased risk among individuals with CHIP driven by mutation in DNA Damage Repair (DDR) genes such as

Identifiants

DOI: 10.1038/s44161-022-00206-6 PMID: 36949957 PMC: PMC10026701
pubmed: 36949957
doi: 10.1038/s44161-022-00206-6
pmc: PMC10026701
mid: NIHMS1875484
doi:

Types de publication

Journal Article

Langues

eng

Pagination

144-158

Subventions

Organisme : NHLBI NIH HHS
ID : F30 HL149180
Pays : United States
Organisme : NIH HHS
ID : DP5 OD029586
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL163099
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM136651
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148565
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134892
Pays : United States
Organisme : NHLBI NIH HHS
ID : OT3 HL147154
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL080472
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007208
Pays : United States
Organisme : CSRD VA
ID : IK2 CX001780
Pays : United States
Organisme : BLRD VA
ID : IK2 BX005759
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA263555
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148050
Pays : United States

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Auteurs

Seyedeh M Zekavat (SM)

Massachusetts Eye and Ear Institute, Department of Ophthalmology, Boston, MA, USA.
Computational Biology & Bioinformatics Program, Yale University, New Haven, CT, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Vanesa Viana-Huete (V)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Nuria Matesanz (N)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Saman Doroodgar Jorshery (SD)

Vector Institute for Artificial Intelligence, Toronto, ON, Canada.
Department of Electrical Engineering and Computer Science and Institute for Medical and Evaluative Sciences, Massachusetts Institute of Technology, Cambridge, MA.

María A Zuriaga (MA)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Md Mesbah Uddin (MM)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

Mark Trinder (M)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Center for Heart Lung Innovation, University of British Columbia, Vancouver.

Kaavya Paruchuri (K)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.

Virginia Zorita (V)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Alba Ferrer-Pérez (A)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Marta Amorós-Pérez (M)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Paolo Kunderfranco (P)

IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.

Roberta Carriero (R)

IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.

Carolina M Greco (CM)

IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.

Alejandra Aroca-Crevillen (A)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Andrés Hidalgo (A)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

Scott M Damrauer (SM)

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA.
Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Christie M Ballantyne (CM)

Center for Cardiometabolic Disease Prevention, Baylor College of Medicine, Houston, TX, USA.

Abhishek Niroula (A)

Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Department of Laboratory Medicine, Lund University, Lund, Sweden.

Christopher J Gibson (CJ)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

James Pirruccello (J)

Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Division of Cardiology, University of California San Francisco.

Gabriel Griffin (G)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

Benjamin L Ebert (BL)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Howard Hughes Medical Institute, Boston, MA.

Peter Libby (P)

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Valentín Fuster (V)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Hongyu Zhao (H)

Department of Biostatistics, Yale School of Public Health, New Haven, CT.

Marzyeh Ghassemi (M)

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Vector Institute for Artificial Intelligence, Toronto, ON, Canada.

Pradeep Natarajan (P)

Department of Medicine, Harvard Medical School, Boston, MA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA.
Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Alexander G Bick (AG)

Division of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.

José J Fuster (JJ)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
CIBER en Enfermedades Cardiovasculares (CIBER-CV), Madrid, Spain.
ORCID: 0000-0002-5970-629X

Derek Klarin (D)

VA Palo Alto Healthcare System, Palo Alto, CA, USA.
Department of Surgery, Stanford University School of Medicine, Palo Alto, CA.
ORCID: 0000-0002-4636-5780

Classifications MeSH