Genome mining unveils a class of ribosomal peptides with two amino termini.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
23 03 2023
Historique:
received: 25 05 2022
accepted: 09 03 2023
entrez: 24 3 2023
pubmed: 25 3 2023
medline: 28 3 2023
Statut: epublish

Résumé

The era of inexpensive genome sequencing and improved bioinformatics tools has reenergized the study of natural products, including the ribosomally synthesized and post-translationally modified peptides (RiPPs). In recent years, RiPP discovery has challenged preconceptions about the scope of post-translational modification chemistry, but genome mining of new RiPP classes remains an unsolved challenge. Here, we report a RiPP class defined by an unusual (S)-N

Identifiants

pubmed: 36959188
doi: 10.1038/s41467-023-37287-1
pii: 10.1038/s41467-023-37287-1
pmc: PMC10036551
doi:

Substances chimiques

Peptides 0
Carboxy-Lyases EC 4.1.1.-
Biological Products 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1624

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI144967
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM123998
Pays : United States

Commentaires et corrections

Type : UpdateOf

Informations de copyright

© 2023. The Author(s).

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Auteurs

Hengqian Ren (H)

Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Shravan R Dommaraju (SR)

Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Chunshuai Huang (C)

Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Haiyang Cui (H)

Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Yuwei Pan (Y)

Department of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Marko Nesic (M)

Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Lingyang Zhu (L)

School of Chemical Sciences, NMR Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

David Sarlah (D)

Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Douglas A Mitchell (DA)

Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. douglasm@illinois.edu.
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA. douglasm@illinois.edu.
Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. douglasm@illinois.edu.

Huimin Zhao (H)

Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. zhao5@illinois.edu.
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. zhao5@illinois.edu.
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA. zhao5@illinois.edu.
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. zhao5@illinois.edu.

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Classifications MeSH