Repeatability of Quantitative Magnetic Resonance Imaging Biomarkers in the Tibia Bone Marrow of a Murine Myelofibrosis Model.
apparent diffusion coefficient, ADC
bone marrow, BM
magnetization transfer ratio, MTR
murine model of myelofibrosis, MF
proton density fat fraction, PDFF
quantitative MRI
quantitative imaging biomarker, QIB
repeatability
Journal
Tomography (Ann Arbor, Mich.)
ISSN: 2379-139X
Titre abrégé: Tomography
Pays: Switzerland
ID NLM: 101671170
Informations de publication
Date de publication:
28 02 2023
28 02 2023
Historique:
received:
30
01
2023
revised:
23
02
2023
accepted:
24
02
2023
entrez:
24
3
2023
pubmed:
25
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
Quantitative MRI biomarkers are sought to replace painful and invasive sequential bone-marrow biopsies routinely used for myelofibrosis (MF) cancer monitoring and treatment assessment. Repeatability of MRI-based quantitative imaging biomarker (QIB) measurements was investigated for apparent diffusion coefficient (ADC), proton density fat fraction (PDFF), and magnetization transfer ratio (MTR) in a JAK2 V617F hematopoietic transplant model of MF. Repeatability coefficients (RCs) were determined for three defined tibia bone-marrow sections (2-9 mm; 10-12 mm; and 12.5-13.5 mm from the knee joint) across 15 diseased mice from 20-37 test-retest pairs. Scans were performed on consecutive days every two weeks for a period of 10 weeks starting 3-4 weeks after transplant. The mean RC with (95% confidence interval (CI)) for these sections, respectively, were for ADC: 0.037 (0.031, 0.050), 0.087 (0.069, 0.116), and 0.030 (0.022, 0.044) μm
Identifiants
pubmed: 36961004
pii: tomography9020045
doi: 10.3390/tomography9020045
pmc: PMC10037563
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
552-566Subventions
Organisme : NCI NIH HHS
ID : R01 CA238023
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197701
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA237683
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA046592
Pays : United States
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