Age or age of onset: which is the best criterion to classify late-life depression?
Journal
International clinical psychopharmacology
ISSN: 1473-5857
Titre abrégé: Int Clin Psychopharmacol
Pays: England
ID NLM: 8609061
Informations de publication
Date de publication:
01 07 2023
01 07 2023
Historique:
medline:
2
6
2023
pubmed:
25
3
2023
entrez:
24
3
2023
Statut:
ppublish
Résumé
In late-life depression (LLD), several differences between patients whose first episode is reported after age 65 (late-onset depression, LOD) and those with early-onset depression (EOD) might reflect the effects of brain ageing. To test this hypothesis, we analysed the impact of current age and age at illness onset on a number of clinical and cognitive manifestations in 438 outpatients with major depressive disorder aged >60 years, treated with venlafaxine for 12 weeks. When compared to the EOD group, patients with LOD were older ( P < 0.00001) and associated with lower depression severity ( P = 0.0029), lower global cognitive functioning [Mini-Mental State Examination (MMSE): P = 0.0001; Repeatable Battery for the Assessment of Neuropsychological Status: immediate memory, P = 0.0009, and delayed memory, P < 0.00001; Delis-Kaplan Executive Function System measuring executive functions: Trail-Making Test (TMT) - P = 0.0004 and Colour-Word Interference Test, Inhibition - P = 0.0063], and more dyskinesias (Abnormal Involuntary Movement Scale: P = 0.0006). After controlling for its interactions with age of onset, current age was inversely correlated with Montgomery Åsberg Depression Rating Scale scores at baseline ( P < 0.00001) and week 12 ( P = 0.0066), MMSE ( P < 0.00001), delayed memory ( P < 0.00001), and TMT ( P = 0.0021). Age of onset predicted impairment in immediate ( P = 0.023) and delayed memory ( P = 0.0181), and dyskinesias ( P = 0.0006). Although most features of LLD are related to ageing rather than to late-onset, LOD is a possible separate diagnostic entity characterised by memory dysfunction and increased liability to movement disorders.
Identifiants
pubmed: 36961017
doi: 10.1097/YIC.0000000000000472
pii: 00004850-202307000-00005
pmc: PMC10234317
doi:
Banques de données
ClinicalTrials.gov
['NCT00892047']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
223-230Informations de copyright
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.
Références
Almdahl IS, Agartz I, Hugdahl K, Korsnes MS; Alzheimer’s Disease Neuroimageing Initiative (2022). Brain pathology and cognitive scores prior to onset of late-life depression. Int J Geriatr Psychiatry 37. doi:10.1002/gps.5686.
doi: 10.1002/gps.5686
Amarya S, Singh K, Sabharwal M (2018). Ageing process and physiological changes. IntechOpen. DOI: 10.5772/intechopen.76249
Amrhein V, Greenland S, McShane B (2019). Scientists rise up against statistical significance. Nature 567:305–307.
Ballmaier M, Kumar A, Elderkin-Thompson V, Narr KL, Luders E, Thompson PM, et al. (2008). Mapping callosal morphology in early- and late-onset elderly depression: an index of distinct changes in cortical connectivity. Neuropsychopharmacology 33:1528–1536.
Barnes TR (1989). A rating scale for drug-induced akathisia. Br J Psychiatry 154:672–676.
Barrenetxea J, Pan A, Feng Q, Koh W-P (2022). Factors associated with depression across age groups of older adults: the Singapore Chinese health study. Int J Geriatr Psychiatry 37.
Beck AT, Kovacs M, Weissman A (1979). Assessment of suicidal intention: the scale for suicide ideation. J Consult Clin Psychol 47:343–352.
Beekman AT, Copeland JR, Prince MJ (1999). Review of community prevalence of depression in later life. Br J Psychiatry 174:307–311.
Benazzi F (2004). Early onset vs late onset non-psychotic, non-melancholic unipolar depression. Int J Geriatr Psychiatry 19:701–703.
Cheng YC, Liu SI, Chen CH, Liu HC, Lu ML, Chang CJ, et al. (2020). Comparison of cognitive function between early- and late-onset late-life depression in remission. Psychiatry Res 290:113051.
Cohen-Mansfield J, Shmotkin D, Blumstein Z, Shorek A, Eyal N, Hazan H, et al. (2013). The old, old-old, and the oldest old: continuation or distinct categories? An examination of the relationship between age and changes in health, function, and wellbeing. Int J Aging Hum Dev 77:37–57.
Comijs HC, Nieuwesteeg J, Kok R, van Marwijk HW, van der Mast RC, Naarding P, et al. (2015). The two-year course of late-life depression; results from the Netherlands study of depression in older persons. BMC Psychiatry 15:20.
Cristancho P, Lenze EJ, Dixon D, Miller JP, Mulsant BH, Reynolds CF, et al. (2018). Executive function predicts antidepressant treatment noncompletion in late-life depression. J Clin Psychiatry 79:16m11371.
Derogatis LR, Melisaratos N (1983). The Brief Symptom Inventory: an introductory report. Psychol Med 13:595–605.
Diniz BS, Vieira EM, Mendes-Silva AP, Bowie CR, Butters MA, Fischer CE, et al. (2021). Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults. Alzheimers Dement 7:e12129.
Djernes JK (2006). Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr Scand 113:372–387.
Erlangsen A, Conwell Y (2014). Age-related response to redeemed antidepressants measured by completed suicide in older adults: a nationwide cohort study. Am J Geriatr Psychiatry 22:25–33.
Fanelli G, Benedetti F, Wang S-M, Lee S-J, Jun T-Y, Masand PS, et al. (2019). Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly depression. J Affect Disord 249:410–417.
Fanelli G, Benedetti F, Wang S-M, Lee S-J, Jun T-Y, Masand PS, et al. (2020). Reduced plasma Fetuin-A is a promising biomarker of depression in the elderly. Eur Arch Psychiatry Clin Neurosci 270:901–910.
Faul F, Erdfelder E, Lang A-G, Buchner A (2007). G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39:175–191.
Fernandez-Rodrigues V, Sanchez-Carro Y, Lagunas LN, Rico-Uribe LA, Pemau A, Diaz-Carracedo P, et al. (2022). Risk factors for suicidal behaviour in late-life depression: a systematic review. World J Psychiatry 12:187–203.
Fine EM, Delis DC (2011). Delis–Kaplan executive functioning system. In: Kreutzer JS, DeLuca J, Caplan B, editors. Encyclopedia of clinical neuropsychology. Springer. pp. 796–801.
First MB, Spitzer RL, Gibbon M, Williams JBW (1996). Structured clinical interview for DSM-IV axis I disorders, clinician version (SCID-CV). American Psychiatric Press.
Folstein MF, Folstein SE, McHugh PR (1975). ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198.
Goldberg S, Smith GS, Barnes A, Ma Y, Kramer E, Robeson K, et al. (2004). Serotonin modulation of cerebral glucose metabolism in normal ageing. Neurobiol Aging 25:167–174.
Gonda X, Molnár E, Torzsa P, Rihmer Z (2009). Characteristics of depression in the elderly. Psychiatr Hung 24:166–174.
Gustafsson H, Nordström A, Nordström P (2015). Depression and subsequent risk of Parkinson disease: a nationwide cohort study. Neurology 84:2422–2429.
Gutsmiedl K, Krause M, Bighelli I, Schneider-Thoma J, Leucht S (2020). How well do elderly patients with major depressive disorder respond to antidepressants: a systematic review and single-group meta-analysis. BMC Psychiatry 20:102.
Hall CA, Simon KM, Lenze EJ, Dew MA, Begley A, Butters MA, et al. (2015). Depression remission rates among older black and white adults: analyses from the IRL-GREY trial. Psychiatr Serv 66:1303–1311.
Hamilton M (1960). A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62.
Holroyd S, Duryee JJ (1997). Differences in geriatric psychiatry outpatients with early- vs late-onset depression. Int J Geriatr Psychiatry 12:1100–1106.
Joel I, Begley AE, Mulsant BH, Lenze EJ, Mazumdar S, Dew MA, et al.; IRL GREY Investigative Team (2014). Dynamic prediction of treatment response in late-life depression. Am J Geriatr Psychiatry 22:167–176.
Jordan JT, Chick CF, Rolle CE, Hantke N, Gould CE, Lutz J, et al. (2020). Neurocognitive markers of passive suicidal ideation in late-life depression. Int Psychogeriatr:1–11.
Kazmi H, Walker Z, Booij J, Khan F, Shah S, Sudre CH, et al. (2021). Late onset depression: dopaminergic deficit and clinical features of prodromal Parkinson’s disease: a cross-sectional study. J Neurol Neurosurg Psychiatry 92:158–164.
Kenneally LB, Szűcs A, Szántó K, Dombrovski AY (2019). Familial and social transmission of suicidal behavior in older adults. J Affect Disord 245:589–596.
Kessler RC, Birnbaum H, Bromet E, Hwang I, Sampson N, Shahly V (2010). Age differences in major depression: results from the national comorbidity surveys replication (NCS-R). Psychol Med 40:225–237.
Kim M (2021). Comparison of general health of the older adult population by age and sex. Asia Pac J Converg Res Interchange 7:65–76.
Lane RD, Glazer WM, Hansen TE, Berman WH, Kramer SI (1985). Assessment of tardive dyskinesia using the Abnormal Involuntary Movement Scale. J Nerv Ment Dis 173:353–357.
Lenze EJ, Mulsant BH, Blumberger DM, Karp JF, Newcomer JW, Anderson SJ, et al. (2015). Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial. Lancet 386:2404–2412.
Lin C, Huang C-M, Karim HT, Liu H-L, Lee TM-C, Wu CW, et al. (2021). Greater white matter hyperintensities and the association with executive function in suicide attempters with late-life depression. Neurobiol Aging 103:60–67.
Lingjaerde O, Ahlfors UG, Bech P, Dencker SJ, Elgen K (1987). The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand Suppl 334:1–100.
Linn BS, Linn MW, Gurel L (1968). Cumulative illness rating scale. J Am Geriatr Soc 16:622–626.
Ly M, Karim HT, Becker JT, Lopez OL, Anderson SJ, Aizenstein HJ, et al. (2021). Late-life depression and increased risk of dementia: a longitudinal cohort study. Transl Psychiatr y 11:147.
Mackin RS, Nelson JC, Delucchi KL, Raue PJ, Satre DD, Kiosses DN, et al. (2014). Association of age at depression onset with cognitive functioning in individuals with late-life depression and executive dysfunction. Am J Geriatr Psychiatry 22:1633–1641.
Mallery L, MacLeod T, Allen M, McLean-Veysey P, Rodney-Cail N, Bezanson E, et al. (2019). Systematic review and meta-analysis of second-generation antidepressants for the treatment of older adults with depression: questionable benefit and considerations for frailty. BMC Geriatr 19:306.
Masse C, Chopard G, Bennabi D, Haffen E, Vandel P (2022). Cognitive functions in late-life depression. Geriatr Psychol Neuropsychiatr Vieil doi:10.1684/pnv.2021.1004.
doi: 10.1684/pnv.2021.1004
Meyer TJ, Miller ML, Metzger RL, Borkovec TD (1990). Development and validation of the Penn State Worry Questionnaire. Behav Res Ther 28:487–495.
Miller MD, Paradis CF, Houck PR, Mazumdar S, Stack JA, Rifai AH, et al. (1992). Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Res 41:237–248.
Montgomery SA, Åsberg M (1979). A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382–389.
Obuobi-Donkor G, Nkire N, Agyapong VIO (2021). Prevalence of major depressive disorder and correlates of thoughts of death, suicidal behaviour, and death by suicide in the geriatric population-a general review of literature. Behav Sci 11:142.
Olgiati P, Serretti A (2015). Persistent benefits of slow titration of paroxetine in a six-month follow-up. Hum Psychopharmacol 30:329–333.
Olgiati P, Bajo E, Serretti A; C.E.A.P (Cost-Effectiveness Analysis on Psychiatric Disorders) Group (2014). Benefit of slow titration of paroxetine to treat depression in the elderly. Hum Psychopharmacol 29:544–551.
Pan W, Liu C, Zhu D, Liu Y, Mao P, Ren Y, et al. (2022). Prediction of antidepressant efficacy by cognitive function in first-episode late-life depression: a pilot study. Front Psychiatry 13:916041.
Perry M, Buerke M, Szücs A, Allen TA, Bruine de Bruin W, Szanto K, et al. (2021). A lifetime of challenges: real-life decision outcomes in early- and late-onset suicide attempters. J Affect Disord Rep 4:100105.
Pruckner N, Holthoff-Detto V (2017). Antidepressant pharmacotherapy in old-age depression – a review and clinical approach. Eur J Clin Pharmacol 73:661–667.
Randolph C, Tierney MC, Mohr E, Chase TN (1998). The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity. J Clin Exp Neuropsychol 20:310–319.
Reiss S, Peterson RA, Gursky DM, McNally RJ (1986). Anxiety sensitivity, anxiety frequency and the prediction of fearfulness. Behav Res Ther 24:1–8.
Sachs-Ericsson N, Corsentino E, Moxley J, Hames JL, Rushing NC, Sawyer K, et al. (2013). A longitudinal study of differences in late- and early-onset geriatric depression: depressive symptoms and psychosocial, cognitive, and neurological functioning. Aging Ment Health 17:1–11.
Skoog I (2011). Psychiatric disorders in the elderly. Can J Psychiatry 56:387–397.
Szücs A, Szanto K, Wright AGC, Dombrovski AY (2020). Personality of late- and early-onset elderly suicide attempters. Int J Geriatr Psychiatry 35:384–395.
Taylor WD, Zald DH, Felger JC, Christman S, Claassen DO, Horga G, et al. (2022). Influences of dopaminergic system dysfunction on late-life depression. Mol Psychiatry 27:180–191.
Unützer J (2007). Clinical practice. Late-life depression. N Engl J Med 357:2269–2276.
Vogelzangs N, Comijs HC, Oude Voshaar RC, Stek ML, Penninx BWJH (2014). Late-life depression symptom profiles are differentially associated with immunometabolic functioning. Brain Behav Immun 41:109–115.
Wang S, Mao S, Xiang D, Fang C (2018). Association between depression and the subsequent risk of Parkinson’s disease: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 86:186–192.
Ware JE, Sherbourne CD (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473–483.
Wei J, Lu Y, Li K, Goodman M, Xu H (2022). The associations of late-life depression with all-cause and cardiovascular mortality: the NHANES 2005-2014. J Affect Disord 300:189–194.
Xiao L, Zhou JJ, Feng Y, Zhu XQ, Wu WY, Hu YD, et al. (2020). Does early and late life depression differ in residual symptoms, functioning and quality of life among the first-episode major depressive patients. Asian J Psychiatr 47:101843.