Sexuality and fertility desire in a large cohort of individuals with 46, XY differences in sex development.
Differences of sex development
Gender change
Human sexuality
Sexual life
Sexual orientation
Journal
Clinics (Sao Paulo, Brazil)
ISSN: 1980-5322
Titre abrégé: Clinics (Sao Paulo)
Pays: United States
ID NLM: 101244734
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
11
2022
revised:
31
01
2023
accepted:
02
03
2023
medline:
30
3
2023
entrez:
25
3
2023
pubmed:
26
3
2023
Statut:
epublish
Résumé
To analyze aspects of sexual life and fertility desire among 46, XY DSD people, including those who changed their gender. It is a cross-sectional study including 127 adults (> 16 years of age) with 46, XY DSD (83 females; 44 males) from a Single Brazilian Tertiary-Care Medical Center. Sexual fantasies and masturbation were more frequent in 46, XY DSD males, whereas orgasm and sexual life satisfaction were similar in both genders. More 46, XY DSD men than women had a long-term romantic relationship. 46, XY DSD women with prenatal androgen exposure reported more fear of being romantically rejected. External genitalia appearance at birth did not impact the sexuality of 46, XY DSD women after surgical genital treatment had been completed. Overall, the sexual life was similar between 46, XY men assigned as males and those who changed to the male gender. Regarding sexual orientation, most self-reported as heterosexual (91% and 92% of women and men, respectively). The desire for fertility had a similar prevalence in both genders, but more women than men considered infertility a barrier to a long-term romantic relationship. Twelve individuals (7 males) had children; 10 out of 12 have adopted children. Fertility desire was shared among 46, XY DSD people, regardless of gender. Prenatal androgen exposure reduced the desire for motherhood in 46, XY women. 46, XY DSD people who changed from female to male gender presented similar sexual parameters as those assigned as males. Among females, virilized genitalia at birth did not affect sexuality once the surgical treatment is completed.
Identifiants
pubmed: 36965237
pii: S1807-5932(23)00021-2
doi: 10.1016/j.clinsp.2023.100185
pmc: PMC10091460
pii:
doi:
Substances chimiques
Androgens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
100185Informations de copyright
Copyright © 2023 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest The authors declare no conflicts of interest.
Références
J Pediatr Urol. 2012 Dec;8(6):611-5
pubmed: 23158651
Ann N Y Acad Sci. 2003 Dec;1007:272-82
pubmed: 14993060
J Steroid Biochem Mol Biol. 2017 Jan;165(Pt A):79-85
pubmed: 27163392
J Sex Res. 2016;53(1):109-24
pubmed: 26133743
J Sex Med. 2012 Dec;9(12):3154-70
pubmed: 20059666
Psychol Women Q. 2010 Sep 1;34(3):394-404
pubmed: 20824180
Arch Sex Behav. 2016 Oct;45(7):1807-15
pubmed: 26940967
J Clin Endocrinol Metab. 2006 Sep;91(9):3310-5
pubmed: 16757528
Front Neuroendocrinol. 2011 Apr;32(2):183-200
pubmed: 21397624
Radiographics. 2012 Oct;32(6):1599-618
pubmed: 23065160
Endocr Rev. 2019 Dec 1;40(6):1547-1572
pubmed: 31365064
J Urol. 2010 Sep;184(3):1122-7
pubmed: 20650476
An Pediatr (Engl Ed). 2018 Nov;89(5):315.e1-315.e19
pubmed: 30033107
Rev Saude Publica. 2016 Feb;50 Suppl 1:15s
pubmed: 26910547
J Clin Endocrinol Metab. 2011 Feb;96(2):296-307
pubmed: 21147889
Child Dev. 1994 Aug;65(4):1042-53
pubmed: 7956464
Mol Cell Endocrinol. 2002 Dec 30;198(1-2):51-9
pubmed: 12573814
Semin Reprod Med. 2012 Oct;30(5):427-31
pubmed: 23044880
Lancet. 2003 Apr 12;361(9365):1252-7
pubmed: 12699952
Sex Dev. 2008;2(4-5):268-77
pubmed: 18987501
J Clin Endocrinol Metab. 2019 Apr 1;104(4):1160-1170
pubmed: 30388241
J Sex Med. 2018 May;15(5):777-785
pubmed: 29606626
J Steroid Biochem Mol Biol. 2016 Oct;163:206-11
pubmed: 27224879
Arch Sex Behav. 2011 Oct;40(5):983-94
pubmed: 21293916
J Pediatr Urol. 2016 Jun;12(3):139-49
pubmed: 27132944
J Sex Marital Ther. 2019;45(3):201-205
pubmed: 30672387
Arch Sex Behav. 1997 Dec;26(6):643-58
pubmed: 9415799
Horm Behav. 2016 Nov;86:8-20
pubmed: 27576114
Arch Sex Behav. 2008 Apr;37(2):266-78
pubmed: 17333329
Mol Cell Endocrinol. 2018 May 15;467:3-13
pubmed: 28847741
Horm Metab Res. 2015 May;47(5):361-6
pubmed: 25853895
Clinics (Sao Paulo). 2006 Jun;61(3):209-14
pubmed: 16832553
Psychoneuroendocrinology. 2018 Mar;89:250-255
pubmed: 29398092
Best Pract Res Clin Endocrinol Metab. 2010 Apr;24(2):325-34
pubmed: 20541155
Clin Endocrinol (Oxf). 2018 Aug;89(2):164-177
pubmed: 29668062
Biochem Med (Zagreb). 2013;23(2):143-9
pubmed: 23894860
J Pediatr Adolesc Gynecol. 2020 Oct;33(5):470-476
pubmed: 32473322
BJU Int. 2004 May;93 Suppl 3:54-6
pubmed: 15086444
J Clin Endocrinol Metab. 2012 Feb;97(2):577-88
pubmed: 22090272
Arch Sex Behav. 2008 Feb;37(1):85-99
pubmed: 18157628
Fertil Steril. 2017 Nov;108(5):822-831
pubmed: 28923284
Health Psychol. 2018 Apr;37(4):334-343
pubmed: 29608076
J Homosex. 1985 Spring;11(1-2):35-49
pubmed: 4056393
J Clin Endocrinol Metab. 2003 Mar;88(3):1102-6
pubmed: 12629091
Am J Med Genet. 1996 May 3;63(1):223-30
pubmed: 8723114
Fertil Steril. 1997 Feb;67(2):229-32
pubmed: 9022594
Clin Endocrinol (Oxf). 2012 Jun;76(6):894-8
pubmed: 22211628
Adv Exp Med Biol. 2011;707:9-14
pubmed: 21691945
Horm Behav. 2011 Apr;59(4):549-55
pubmed: 21338606
Endocrinol Metab Clin North Am. 2015 Dec;44(4):867-81
pubmed: 26568498
J Pediatr Urol. 2016 Dec;12(6):418-425
pubmed: 27856173
Front Neuroendocrinol. 2011 Apr;32(2):214-26
pubmed: 21334362
J Sex Marital Ther. 2010;36(3):193-215
pubmed: 20432122
Front Psychol. 2015 Oct 01;6:1511
pubmed: 26483748