Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
25 03 2023
25 03 2023
Historique:
received:
19
04
2022
accepted:
14
03
2023
medline:
28
3
2023
entrez:
25
3
2023
pubmed:
26
3
2023
Statut:
epublish
Résumé
High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, we investigate how aneuploidy in HeH ALL arises. Single cell whole genome sequencing of 2847 cells from nine primary cases and one normal bone marrow reveals that HeH ALL generally display low chromosomal heterogeneity, indicating that they are not characterized by chromosomal instability and showing that aneuploidy-driven malignancies are not necessarily chromosomally heterogeneous. Furthermore, most chromosomal gains are present in all leukemic cells, suggesting that they arose early during leukemogenesis. Copy number data from 577 primary cases reveals selective pressures that were used for in silico modeling of aneuploidy development. This shows that the aneuploidy in HeH ALL likely arises by an initial tripolar mitosis in a diploid cell followed by clonal evolution, in line with a punctuated evolution model.
Identifiants
pubmed: 36966135
doi: 10.1038/s41467-023-37356-5
pii: 10.1038/s41467-023-37356-5
pmc: PMC10039905
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1658Informations de copyright
© 2023. The Author(s).
Références
Genes Chromosomes Cancer. 2016 Sep;55(9):727-37
pubmed: 27163296
Science. 2008 Nov 28;322(5906):1377-80
pubmed: 19039135
Bioinformatics. 2019 Feb 1;35(3):526-528
pubmed: 30016406
Front Cell Dev Biol. 2021 Aug 04;9:631946
pubmed: 34422788
Pediatr Blood Cancer. 2014 Dec;61(12):2208-14
pubmed: 25174722
Nature. 2013 Aug 22;500(7463):415-21
pubmed: 23945592
Curr Protoc Bioinformatics. 2013;43:11.10.1-11.10.33
pubmed: 25431634
Nat Commun. 2020 Feb 5;11(1):734
pubmed: 32024818
Nature. 2013 Jul 11;499(7457):214-218
pubmed: 23770567
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Genome Biol. 2016 May 31;17(1):115
pubmed: 27246460
Nat Genet. 2016 Oct;48(10):1119-30
pubmed: 27526321
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21719-24
pubmed: 21098271
Blood. 1992 Jul 1;80(1):203-8
pubmed: 1351763
Leukemia. 2013 Feb;27(2):493-6
pubmed: 22801382
Genes Chromosomes Cancer. 2007 Jul;46(7):684-93
pubmed: 17431878
Nature. 2009 Jul 9;460(7252):278-82
pubmed: 19506557
Leukemia. 2003 Nov;17(11):2202-6
pubmed: 12931229
Eur J Haematol. 2018 Jan;100(1):104-107
pubmed: 29034503
Genome Biol. 2011 Oct 24;12(10):R108
pubmed: 22023820
Haematologica. 2013 Sep;98(9):1424-32
pubmed: 23645689
Genes Chromosomes Cancer. 2009 Aug;48(8):637-60
pubmed: 19415723
Nature. 2007 Apr 12;446(7137):758-64
pubmed: 17344859
Leukemia. 2010 May;24(5):924-31
pubmed: 20237506
Leukemia. 2015 Jan;29(1):58-65
pubmed: 24897505
Commun Biol. 2020 Aug 3;3(1):421
pubmed: 32747711
Nat Methods. 2015 Nov;12(11):1058-60
pubmed: 26344043
Genes Chromosomes Cancer. 2004 May;40(1):38-43
pubmed: 15034866
Nature. 2018 Mar 15;555(7696):371-376
pubmed: 29489755
Leukemia. 2001 Sep;15(9):1415-23
pubmed: 11516102
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21119-23
pubmed: 24324169
Genome Biol. 2022 Nov 14;23(1):241
pubmed: 36376909
Blood. 2003 Oct 15;102(8):3010-5
pubmed: 12829594
Nature. 2020 Feb;578(7793):94-101
pubmed: 32025018
Elife. 2015 May 05;4:
pubmed: 25942454
Nat Rev Mol Cell Biol. 2009 Jul;10(7):478-87
pubmed: 19546858
Nat Genet. 2016 Feb;48(2):126-133
pubmed: 26656846
Science. 1976 Oct 1;194(4260):23-8
pubmed: 959840
Nat Genet. 2015 Jun;47(6):672-6
pubmed: 25961940
Blood. 2013 Mar 28;121(13):2415-23
pubmed: 23321258
Cell. 2019 May 2;177(4):821-836.e16
pubmed: 30982602
Biochim Biophys Acta Rev Cancer. 2017 Apr;1867(2):151-161
pubmed: 28110020
Genome Med. 2018 Apr 25;10(1):33
pubmed: 29695279
Methods Mol Biol. 2019;1896:159-190
pubmed: 30474848
Nat Genet. 2021 Aug;53(8):1187-1195
pubmed: 34211178
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Leuk Lymphoma. 2001 Jun;42(1-2):187-93
pubmed: 11699206
Leukemia. 1996 Feb;10(2):213-24
pubmed: 8637229
Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20489-93
pubmed: 21059955
Genes Chromosomes Cancer. 2005 Oct;44(2):113-22
pubmed: 15942938
PLoS One. 2013 Jul 24;8(7):e70445
pubmed: 23894657
Blood. 2020 Jan 2;135(1):41-55
pubmed: 31697823
Blood. 2020 Jul 16;136(3):313-327
pubmed: 32321174
Genes Chromosomes Cancer. 2021 Jun;60(6):410-417
pubmed: 33368842