Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
25 03 2023
25 03 2023
Historique:
received:
24
08
2022
accepted:
16
02
2023
revised:
08
02
2023
medline:
28
3
2023
entrez:
25
3
2023
pubmed:
26
3
2023
Statut:
epublish
Résumé
Existing guidelines recommend psychopharmacological treatment for the management of schizophrenia and bipolar disorder as part of holistic treatment concepts. About half of the patients do not take their medication regularly, although treatment adherence can prevent exacerbations and re-hospitalizations. To date, the relationship between medication adherence and cognitive performance is understudied. Therefore, this study investigated the relationship between medication adherence and cognitive performance by analyzing the data of 862 participants with schizophrenia-spectrum and bipolar disorders (mean [SD] age, 41.9 [12.48] years; 44.8% female) from a multicenter study (PsyCourse Study). Z-scores for three cognitive domains were calculated, global functioning was measured with the Global Assessment of Functioning Scale, and adherence was assessed by a self-rating questionnaire. We evaluated four multiple linear regression models and built three clusters with hierarchical cluster analyses. Higher adherence behavior (p < 0.001) was associated with better global functioning but showed no impact on the cognitive domains learning and memory, executive function, and psychomotor speed. The hierarchical cluster analysis resulted in three clusters with different cognitive performances, but patients in all clusters showed similar adherence behavior. The study identified cognitive subgroups independent of diagnoses, but no differences were found in the adherence behavior of the patients in these new clusters. In summary, medication adherence was associated with global but not cognitive functioning in patients with schizophrenia-spectrum and bipolar disorders. In both diagnostic groups, cognitive function might be influenced by various factors but not medication adherence.
Identifiants
pubmed: 36966169
doi: 10.1038/s41398-023-02373-x
pii: 10.1038/s41398-023-02373-x
pmc: PMC10039892
doi:
Types de publication
Multicenter Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
99Informations de copyright
© 2023. The Author(s).
Références
Epidemiol Rev. 2008;30:77-83
pubmed: 18587141
Curr Psychiatry Rep. 2019 Feb 7;21(2):10
pubmed: 30729322
J Affect Disord. 2012 Dec 15;142(1-3):13-21
pubmed: 22840620
Fortschr Neurol Psychiatr. 2011 Feb;79(2):73-82
pubmed: 21108162
Schizophr Res. 2019 Aug;210:21-29
pubmed: 31272906
J Clin Psychiatry. 2014;75 Suppl 2:8-13
pubmed: 24919165
Am J Psychiatry. 2002 Jul;159(7):1183-9
pubmed: 12091197
Hippocampus. 2005;15(3):340-6
pubmed: 15744736
Chin Med J (Engl). 2016 Mar 5;129(5):578-85
pubmed: 26904993
Psychol Med. 2005 Feb;35(2):205-15
pubmed: 15841678
Syst Rev. 2018 Jan 22;7(1):10
pubmed: 29357926
Lancet. 2016 Jul 2;388(10039):86-97
pubmed: 26777917
Neuropsychology. 1998 Jul;12(3):426-45
pubmed: 9673998
Pharmacoeconomics. 2000 Aug;18(2):106-24
pubmed: 11067646
Schizophr Res. 2008 Mar;100(1-3):60-9
pubmed: 18255269
Gen Hosp Psychiatry. 2021 Mar-Apr;69:94-103
pubmed: 33588196
Br J Clin Pharmacol. 2020 Jul;86(7):1281-1288
pubmed: 31823381
Indian J Psychiatry. 2019;61(4):342-346
pubmed: 31391636
Psychol Med. 2008 Jun;38(6):771-85
pubmed: 17922938
Br J Psychiatry. 1978 Nov;133:429-35
pubmed: 728692
Lancet. 2016 Apr 9;387(10027):1561-1572
pubmed: 26388529
Syst Rev. 2020 Jan 16;9(1):17
pubmed: 31948489
CNS Neurosci Ther. 2012 Mar;18(3):194-200
pubmed: 22128808
World Psychiatry. 2008 Feb;7(1):22-8
pubmed: 18458774
Psychother Psychosom. 2000;69(1):2-18
pubmed: 10601830
Eur Neuropsychopharmacol. 2016 Oct;26(10):1541-61
pubmed: 27593623
Exp Gerontol. 1998 Nov-Dec;33(7-8):661-73
pubmed: 9951614
Am J Psychiatry. 2004 Feb;161(2):262-70
pubmed: 14754775
Schizophr Bull. 1987;13(2):261-76
pubmed: 3616518
Arch Gen Psychiatry. 1994 Feb;51(2):124-31
pubmed: 7905258
Neuropharmacology. 2020 May 15;168:107634
pubmed: 31077729
Psychol Med. 2015 Jan;45(2):381-94
pubmed: 25065268
Lancet. 2009 Jan 17;373(9659):234-9
pubmed: 19150704
Curr Alzheimer Res. 2016;13(8):887-93
pubmed: 27087441
Psychiatry (Edgmont). 2007 Jul;4(7):28-37
pubmed: 20526405
Int J Methods Psychiatr Res. 2007;16(4):230-6
pubmed: 18200596
Am J Med Genet B Neuropsychiatr Genet. 2019 Mar;180(2):89-102
pubmed: 30070057
Front Psychiatry. 2022 Jan 20;12:713060
pubmed: 35126191
J Clin Psychiatry. 2002 Oct;63(10):892-909
pubmed: 12416599
Am J Psychiatry. 2000 Apr;157(4):549-59
pubmed: 10739413
Neurosci Biobehav Rev. 2021 Jul;126:265-275
pubmed: 33812977
Schizophr Res. 2011 Apr;127(1-3):83-92
pubmed: 21257294
Schizophr Res. 2017 Dec;190:129-135
pubmed: 28390849
Bipolar Disord. 2015 May;17(3):248-56
pubmed: 25257942
Lancet. 2013 Apr 20;381(9875):1371-1379
pubmed: 23453885
Bipolar Disord. 2011 Jun;13(4):334-42
pubmed: 21843273
Schizophr Bull. 2016 May;42(3):608-18
pubmed: 26433217
Clin Psychol Rev. 2018 Feb;59:126-136
pubmed: 29195773
Schizophr Res. 2022 Jun;244:29-38
pubmed: 35567871
Biometrics. 2017 Sep;73(3):811-821
pubmed: 28099990
Ann Gen Psychiatry. 2011 Jan 20;10:2
pubmed: 21251305
Biol Psychiatry. 2006 Jan 15;59(2):138-46
pubmed: 16169530
N Engl J Med. 2005 Aug 4;353(5):487-97
pubmed: 16079372
Acta Psychiatr Scand. 2013 Sep;128(3):149-62
pubmed: 23617548
BMJ. 1996 Feb 10;312(7027):345-9
pubmed: 8611831
Br Med Bull. 2015 Jun;114(1):169-79
pubmed: 25957394
Behav Res Methods. 2007 Nov;39(4):709-22
pubmed: 18183883