Ocular manifestations of vitiligo: a systematic review.
cataract
dry eye disease
glaucoma
melanocyte
vitiligo
Journal
BMC ophthalmology
ISSN: 1471-2415
Titre abrégé: BMC Ophthalmol
Pays: England
ID NLM: 100967802
Informations de publication
Date de publication:
27 Mar 2023
27 Mar 2023
Historique:
received:
13
08
2022
accepted:
11
01
2023
medline:
29
3
2023
entrez:
27
3
2023
pubmed:
28
3
2023
Statut:
epublish
Résumé
Vitiligo is a disorder characterized by loss of epidermal melanocytes, resulting in depigmented macules and patches. While the relationship between ocular pathology and vitiligo has been demonstrated in conditions such as Vogt-Koyanagi-Harada and Alezzandrini syndromes, the ocular associations of non-syndromic vitiligo are incompletely understood. We conducted a systematic review to comprehensively describe the structural and functional changes seen in the eyes of patients with vitiligo, to identify patients at heightened risk for ocular disease, and to provide an approach to management of ocular manifestations of vitiligo. Overall, the strongest link between vitiligo and ocular pathology seems to lie with dry eye disease and pigmentary abnormalities of various ocular structures, especially the retinal pigment epithelium. Normal-tension glaucoma may also be more prevalent in the vitiligo population. The available literature did not provide conclusive evidence for increased risk of cataracts or uveitis. Aside from the impact of symptomatic dry eye disease, it seems unlikely that there are significant functional consequences of these ocular manifestations such as impaired visual acuity or visual fields.
Identifiants
pubmed: 36973683
doi: 10.1186/s12886-023-02777-9
pii: 10.1186/s12886-023-02777-9
pmc: PMC10041747
doi:
Types de publication
Systematic Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
120Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Références
Am J Ophthalmol. 1983 Jul;96(1):16-26
pubmed: 6869476
Cutan Ocul Toxicol. 2016;35(2):104-9
pubmed: 25942691
Ophthalmic Res. 2008 Oct;40(6):315-21
pubmed: 18688174
Ann Ophthalmol. 1979 Jun;11(6):946-8
pubmed: 496187
J Am Acad Dermatol. 1986 Jul;15(1):17-24
pubmed: 3722505
J Eur Acad Dermatol Venereol. 2006 Aug;20(7):829-33
pubmed: 16898906
Arch Ophthalmol. 2000 May;118(5):615-21
pubmed: 10815152
Graefes Arch Clin Exp Ophthalmol. 2018 May;256(5):927-933
pubmed: 29549426
Cell Tissue Res. 1999 Jan;295(1):65-75
pubmed: 9931354
J Am Acad Dermatol. 2016 Feb;74(2):295-302
pubmed: 26518171
J Res Med Sci. 2013 May;18(5):405-7
pubmed: 24174946
Acta Dermatovenerol Croat. 2010;18(1):21-6
pubmed: 20361884
Cutis. 2016 Apr;97(4):E21-5
pubmed: 27163923
J Am Acad Dermatol. 2011 Sep;65(3):473-491
pubmed: 21839315
Eye (Lond). 2017 Jul;31(7):1074-1077
pubmed: 28282067
BMC Ophthalmol. 2018 May 29;18(1):126
pubmed: 29843674
Br J Ophthalmol. 1983 Mar;67(3):153-6
pubmed: 6824621
J Indian Med Assoc. 2003 Aug;101(8):478-80
pubmed: 15071800
Int J Dermatol. 2016 Mar;55(3):351-5
pubmed: 26235484
Ophthalmology. 1979 Jun;86(6):1145-60
pubmed: 534100
Photochem Photobiol. 2008 May-Jun;84(3):639-44
pubmed: 18346089
Pak J Med Sci. 2015;31(3):587-91
pubmed: 26150849
Ophthalmology. 2007 Mar;114(3):606-14
pubmed: 17123618
J Natl Med Assoc. 2005 Feb;97(2):286-7
pubmed: 15712795
Arch Ophthalmol. 1981 Oct;99(10):1778-87
pubmed: 7295126
Clin Ophthalmol. 2020 Aug 11;14:2265-2270
pubmed: 32848356
J Am Acad Dermatol. 1981 May;4(5):528-36
pubmed: 7195407
Doc Ophthalmol. 2014 Apr;128(2):131-6
pubmed: 24442321
Circ Res. 2006 Jun 23;98(12):1547-54
pubmed: 16709902
N Engl J Med. 1977 Apr 7;296(14):824
pubmed: 840293
J Cutan Med Surg. 2016 Mar-Apr;20(2):146-9
pubmed: 26506954
Eur J Ophthalmol. 2012 Sep-Oct;22(5):734-8
pubmed: 22267461
Indian J Dermatol Venereol Leprol. 2007 May-Jun;73(3):162-5
pubmed: 17558047
Int J Dermatol. 2015 Nov;54(11):e466-8
pubmed: 25601474
Int Ophthalmol. 2018 Feb;38(1):233-239
pubmed: 28108905
G Ital Dermatol Venereol. 2010 Apr;145(2):141-9
pubmed: 20467388
Exp Eye Res. 1997 Aug;65(2):215-22
pubmed: 9268589
Dev Neurobiol. 2020 Nov;80(11-12):411-432
pubmed: 33075185
Cornea. 2018 Apr;37(4):412-415
pubmed: 29300260