The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases.
engram
gut microbiota
gut–brain axis
immune-related disease
inflammation
kynurenine
reactive oxygen species
tryptophan
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Mar 2023
17 Mar 2023
Historique:
received:
30
01
2023
revised:
08
03
2023
accepted:
16
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
The tryptophan and kynurenine pathway is well-known to play an important role in nervous, endocrine, and immune systems, as well as in the development of inflammatory diseases. It has been documented that some kynurenine metabolites are considered to have anti-oxidative, anti-inflammatory, and/or neuroprotective properties. Importantly, many of these kynurenine metabolites may possess immune-regulatory properties that could alleviate the inflammation response. The abnormal activation of the tryptophan and kynurenine pathway might be involved in the pathophysiological process of various immune-related diseases, such as inflammatory bowel disease, cardiovascular disease, osteoporosis, and/or polycystic ovary syndrome. Interestingly, kynurenine metabolites may be involved in the brain memory system and/or intricate immunity via the modulation of glial function. In the further deliberation of this concept with engram, the roles of gut microbiota could lead to the development of remarkable treatments for the prevention of and/or the therapeutics for various intractable immune-related diseases.
Identifiants
pubmed: 36982811
pii: ijms24065742
doi: 10.3390/ijms24065742
pmc: PMC10051340
pii:
doi:
Substances chimiques
Tryptophan
8DUH1N11BX
Kynurenine
343-65-7
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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