Regulation of Aqueous Humor Secretion by Melatonin in Porcine Ciliary Epithelium.
aqueous humor formation
ciliary epithelium
gap junction
glaucoma
melatonin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Mar 2023
17 Mar 2023
Historique:
received:
08
02
2023
revised:
10
03
2023
accepted:
16
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
Secretion of melatonin, a natural hormone whose receptors are present in the ciliary epithelium, displays diurnal variation in the aqueous humor (AH), potentially contributing to the regulation of intraocular pressure. This study aimed to determine the effects of melatonin on AH secretion in porcine ciliary epithelium. The addition of 100 µM melatonin to both sides of the epithelium significantly increased the short-circuit current (Isc) by ~40%. Stromal administration alone had no effect on the Isc, but aqueous application triggered a 40% increase in Isc, similar to that of bilateral application without additive effect. Pre-treatment with niflumic acid abolished melatonin-induced Isc stimulation. More importantly, melatonin stimulated the fluid secretion across the intact ciliary epithelium by ~80% and elicited a sustained increase (~50-60%) in gap junctional permeability between pigmented ciliary epithelial (PE) cells and non-pigmented ciliary epithelial (NPE) cells. The expression of MT
Identifiants
pubmed: 36982863
pii: ijms24065789
doi: 10.3390/ijms24065789
pmc: PMC10051954
pii:
doi:
Substances chimiques
Melatonin
JL5DK93RCL
Carrier Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : General Research Fund
ID : 5609/13M
Organisme : Hong Kong Polytechnic University
ID : 1-CD65
Organisme : Hong Kong Polytechnic University
ID : 1-BBCM
Organisme : Hong Kong Polytechnic University
ID : 1-BBC2
Organisme : Hong Kong Polytechnic University
ID : 1-YWC5
Organisme : Hong Kong Polytechnic University
ID : 1-BD6R
Organisme : Hong Kong Polytechnic University
ID : BBCW
Organisme : Hong Kong Polytechnic University
ID : BD6R
Organisme : InnoHK initiative and the Hong Kong Special Administrative Region Government.
ID : InnoHK initiative and the Hong Kong Special Administrative Region Government.
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