The Microbiota-Gut-Brain Axis: Psychoneuroimmunological Insights.
autoimmunity
brain
gut microbiota
mood
nutrients
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
20 Mar 2023
20 Mar 2023
Historique:
received:
30
01
2023
revised:
18
03
2023
accepted:
19
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
There is growing interest in the role that the intestinal microbiota and the related autoimmune processes may have in the genesis and presentation of some psychiatric diseases. An alteration in the communication of the microbiota-gut-brain axis, which constitutes a communicative model between the central nervous system (CNS) and the gastro-enteric tract, has been identified as one of the possible causes of some psychiatric diseases. The purpose of this narrative review is to describe evidence supporting a role of the gut microbiota in psychiatric diseases and the impact of diet on microbiota and mental health. Change in the composition of the gut microbiota could determine an increase in the permeability of the intestinal barrier, leading to a cytokine storm. This could trigger a systemic inflammatory activation and immune response: this series of events could have repercussions on the release of some neurotransmitters, altering the activity of the hypothalamic-pituitary-adrenal axis, and reducing the presence of trophic brain factors. Although gut microbiota and psychiatric disorders seem to be connected, more effort is needed to understand the potential causative mechanisms underlying the interactions between these systems.
Identifiants
pubmed: 36986226
pii: nu15061496
doi: 10.3390/nu15061496
pmc: PMC10059722
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Shock. 2002 Nov;18(5):465-70
pubmed: 12412628
Am J Physiol Regul Integr Comp Physiol. 2015 Jul 1;309(1):R1-R12
pubmed: 25924881
Schizophr Res. 2016 Sep;176(1):23-35
pubmed: 25034760
Front Genet. 2019 Feb 19;10:98
pubmed: 30838027
Front Immunol. 2017 Jul 28;8:838
pubmed: 28804483
Neuroscience. 2015 Apr 2;290:126-37
pubmed: 25637492
Psychopharmacology (Berl). 2019 May;236(5):1433-1443
pubmed: 31041459
Neuropsychobiology. 2018 Sep 18;:1-8
pubmed: 30227422
Eur J Nutr. 2017 Feb;56(1):119-131
pubmed: 26541328
Front Pharmacol. 2020 Apr 15;11:481
pubmed: 32351392
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5
pubmed: 21876150
Clin Biochem. 2008 Sep;41(13):1044-8
pubmed: 18582451
Neural Plast. 2017;2017:6031478
pubmed: 28596922
Int Rev Psychiatry. 2019 May;31(3):280-294
pubmed: 30784334
Int J Mol Sci. 2020 Aug 31;21(17):
pubmed: 32878032
J Affect Disord. 2005 May;86(1):37-45
pubmed: 15820269
Prog Brain Res. 2008;172:265-86
pubmed: 18772037
Nutrients. 2020 Dec 29;13(1):
pubmed: 33383958
Schizophr Bull. 2012 May;38(3):642-7
pubmed: 22446566
Br J Nutr. 2005 Apr;93 Suppl 1:S27-30
pubmed: 15877891
Sci Transl Med. 2014 Nov 19;6(263):263ra158
pubmed: 25411471
Curr Opin Psychiatry. 2015 Jan;28(1):1-6
pubmed: 25415497
J Neuropathol Exp Neurol. 2002 Nov;61(11):1013-21
pubmed: 12430718
Cell Host Microbe. 2013 Sep 11;14(3):318-28
pubmed: 24034617
Front Nutr. 2019 Apr 17;6:47
pubmed: 31058160
Trends Neurosci. 2013 May;36(5):305-12
pubmed: 23384445
Psychoneuroendocrinology. 2013 Dec;38(12):3039-47
pubmed: 24103889
Neurosci Biobehav Rev. 2008 Aug;32(6):1136-51
pubmed: 18468686
Neurotherapeutics. 2018 Jan;15(1):36-59
pubmed: 29134359
J Pers Med. 2021 Oct 12;11(10):
pubmed: 34683161
J Neuroinflammation. 2019 Mar 1;16(1):53
pubmed: 30823925
Front Biosci (Landmark Ed). 2018 Jan 1;23(5):811-836
pubmed: 28930574
Mol Psychiatry. 2021 Aug;26(8):4085-4095
pubmed: 31732715
Proc Nutr Soc. 2015 Aug;74(3):328-36
pubmed: 25497601
Neurogastroenterol Motil. 2014 Aug;26(8):1155-62
pubmed: 24888394
Front Neurosci. 2018 Feb 07;12:49
pubmed: 29467611
Infect Immun. 2007 Sep;75(9):4597-607
pubmed: 17591798
Int J Eat Disord. 2013 Sep;46(6):639-41
pubmed: 23813727
Brain Behav Immun. 2011 Oct;25(7):1333-41
pubmed: 21536124
Hepatogastroenterology. 1996 Nov-Dec;43(12):1513-7
pubmed: 8975957
Exp Ther Med. 2013 Jul;6(1):93-96
pubmed: 23935726
Nutrients. 2021 Feb 22;13(2):
pubmed: 33671569
Nutrients. 2014 Oct 31;6(11):4822-38
pubmed: 25365383
JAMA Psychiatry. 2021 Dec 1;78(12):1343-1354
pubmed: 34524405
Curr Opin Pharmacol. 2019 Oct;48:99-106
pubmed: 31525562
Bipolar Disord. 2019 Feb;21(1):40-49
pubmed: 30051546
Mol Psychiatry. 2016 Jun;21(6):738-48
pubmed: 27090305
Sci Rep. 2017 Jul 13;7(1):5294
pubmed: 28706193
Neuron. 2019 Mar 20;101(6):998-1002
pubmed: 30897366
Curr Opin Clin Nutr Metab Care. 2015 Nov;18(6):552-8
pubmed: 26372511
J Psychiatr Res. 2016 Nov;82:109-18
pubmed: 27491067
Brain Behav Immun. 2015 Aug;48:186-94
pubmed: 25882912
Bipolar Disord. 2012 Jun;14(4):313-25
pubmed: 22631617
Front Microbiol. 2019 May 16;10:1092
pubmed: 31156598
Nat Commun. 2021 Nov 1;12(1):6289
pubmed: 34725359
Biol Psychiatry. 1984 Mar;19(3):385-99
pubmed: 6609726
Neurosci Biobehav Rev. 2021 Aug;127:37-53
pubmed: 33894241
Curr Psychiatry Rep. 2015 Feb;17(2):8
pubmed: 25620790
Food Funct. 2014 Jun;5(6):1241-9
pubmed: 24722352
Br J Psychiatry. 1982 Sep;141:273-81
pubmed: 7139211
Neuropsychobiology. 2020;79(1):43-49
pubmed: 31722343
J Am Heart Assoc. 2013 Dec 10;2(6):e000455
pubmed: 24326161
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11971-5
pubmed: 20566857
Curr Pharm Des. 2016;22(40):6076-6086
pubmed: 27634185
J Clin Gastroenterol. 2016 Nov/Dec;50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics & Ne:S116-S119
pubmed: 27741152
Annu Rev Genomics Hum Genet. 2012;13:151-70
pubmed: 22703178
Front Behav Neurosci. 2016 Aug 11;10:156
pubmed: 27563288
Psychosom Med. 1962 Mar-Apr;24:187-94
pubmed: 13873828
Eur Rev Med Pharmacol Sci. 2019 Jan;23(1):426-430
pubmed: 30657587
Curr Opin Pharmacol. 2019 Oct;48:82-91
pubmed: 31430598
Neuropharmacology. 2017 Jan;112(Pt B):235-236
pubmed: 27567943
Nature. 2006 Dec 21;444(7122):1022-3
pubmed: 17183309
J Neurosci. 2007 Oct 3;27(40):10695-702
pubmed: 17913903
Br J Nutr. 2012 Sep;108(5):801-9
pubmed: 22717075
Science. 2015 Dec 4;350(6265):1214-5
pubmed: 26785481
Nature. 2014 Jan 23;505(7484):559-63
pubmed: 24336217
Prim Care Companion CNS Disord. 2014;16(1):
pubmed: 24940526
F1000Res. 2020 Jan 31;9:
pubmed: 32051759
Folia Med (Plovdiv). 2016 Dec 1;58(4):264-272
pubmed: 28068285
Nutrients. 2016 Feb 06;8(2):78
pubmed: 26861391
Neuropsychiatr Dis Treat. 2018 Dec 03;14:3329-3337
pubmed: 30584306
Nature. 2012 May 09;486(7402):222-7
pubmed: 22699611
Neuroscience. 2013 Mar 13;233:86-94
pubmed: 23291456
Front Cell Dev Biol. 2021 Mar 11;9:649103
pubmed: 33777957
Cell Host Microbe. 2007 Aug 16;2(2):119-29
pubmed: 18005726
Microorganisms. 2020 Apr 07;8(4):
pubmed: 32272706
Brain Behav Immun. 2017 Nov;66:9-17
pubmed: 28131791
Antioxidants (Basel). 2020 Oct 13;9(10):
pubmed: 33066106
Front Cell Neurosci. 2015 Oct 14;9:392
pubmed: 26528128
Clin Gastroenterol Hepatol. 2016 Nov;14(11):1602-1611.e5
pubmed: 27266978
Microbiol Mol Biol Rev. 2017 Nov 8;81(4):
pubmed: 29118049
Clin Psychol Rev. 2021 Feb;83:101943
pubmed: 33271426
Cell. 2014 Oct 23;159(3):514-29
pubmed: 25417104
Nature. 2001 Oct 18;413(6857):732-8
pubmed: 11607032
Transl Psychiatry. 2013 Oct 01;3:e309
pubmed: 24084940
Nutr Rev. 2016 Jul;74(7):444-54
pubmed: 27261272
Nutrients. 2021 Apr 14;13(4):
pubmed: 33919680
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Front Neurosci. 2022 Mar 23;16:830748
pubmed: 35401095
Nutrients. 2019 Dec 27;12(1):
pubmed: 31892152
Front Microbiol. 2018 Mar 05;9:317
pubmed: 29556222
Clin Psychopharmacol Neurosci. 2015 Dec 31;13(3):239-44
pubmed: 26598580
Curr Pharm Des. 2016;22(8):987-1012
pubmed: 26654772
Schizophr Res. 2005 Jun 1;75(1):139-41
pubmed: 15820333
Neuropharmacology. 2017 Jan;112(Pt B):237-247
pubmed: 27511838
Nat Rev Endocrinol. 2017 Jan;13(1):11-25
pubmed: 27616451
Sci Rep. 2016 May 16;6:25835
pubmed: 27180604
Front Psychiatry. 2020 Jun 10;11:541
pubmed: 32587537
Int J Mol Sci. 2021 Sep 17;22(18):
pubmed: 34576191
Neurosci Biobehav Rev. 2020 Oct;117:26-64
pubmed: 28757456
Ann Rheum Dis. 2003 May;62(5):490-1
pubmed: 12695170
Am J Clin Nutr. 2019 May 1;109(5):1402-1413
pubmed: 31051507
Curr Opin Psychiatry. 2017 Nov;30(6):423-437
pubmed: 28777107
Med Hypotheses. 1999 Feb;52(2):155-62
pubmed: 10340296
Biomed Res Int. 2013;2013:435268
pubmed: 23991417
Prikl Biokhim Mikrobiol. 2009 Sep-Oct;45(5):550-4
pubmed: 19845286
Nat Med. 2018 Oct;24(10):1532-1535
pubmed: 30150716
Neuropsychopharmacology. 2010 Jul;35(8):1734-42
pubmed: 20336058
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Aug 30;102:109951
pubmed: 32335265
Clin Transl Immunology. 2016 Apr 22;5(4):e73
pubmed: 27195116
Brain Res. 2018 Aug 15;1693(Pt B):128-133
pubmed: 29903615
Nutrients. 2021 Jan 10;13(1):
pubmed: 33435203
Obesity (Silver Spring). 2013 Dec;21(12):E607-15
pubmed: 23526699
Intern Med J. 2020 Jan;50(1):24-29
pubmed: 31943622
J Acad Nutr Diet. 2017 Feb;117(2):251-264
pubmed: 27863994
Transl Psychiatry. 2016 Nov 1;6(11):e939
pubmed: 27801892
J Affect Disord. 2016 Sep 15;202:254-7
pubmed: 27288567
Brain Res. 2019 May 15;1711:202-213
pubmed: 30684456
Benef Microbes. 2019 Apr 19;10(4):425-436
pubmed: 30882243
Int Rev Psychiatry. 2006 Apr;18(2):155-72
pubmed: 16777670
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):12-26
pubmed: 16938373
Clin Nutr. 2020 Mar;39(3):676-684
pubmed: 30952533
Am J Clin Nutr. 2017 Oct;106(4):1052-1061
pubmed: 28814395
Psychopharmacology (Berl). 2016 May;233(9):1651-60
pubmed: 26988846
Gut. 2006 Jul;55(7):1037-46
pubmed: 16766754
J Nutr Biochem. 2008 Sep;19(9):587-93
pubmed: 18061431
World J Hepatol. 2022 Oct 27;14(10):1875-1883
pubmed: 36340751
Neuroscience. 2016 Dec 17;339:463-477
pubmed: 27742460
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11070-5
pubmed: 16033867
Int J Mol Sci. 2021 Apr 02;22(7):
pubmed: 33918462
Nature. 2012 Aug 9;488(7410):178-84
pubmed: 22797518
Encephale. 2017 Apr;43(2):183-186
pubmed: 27178256
Nat Microbiol. 2019 Apr;4(4):623-632
pubmed: 30718848
J Psychiatr Res. 2015 Apr;63:1-9
pubmed: 25772005
Exp Mol Pathol. 2017 Feb;102(1):162-180
pubmed: 28077318
Pathol Biol (Paris). 2015 Feb;63(1):35-42
pubmed: 25468489
Gut Microbes. 2017 Mar 4;8(2):172-184
pubmed: 28165863
Nature. 2009 Aug 6;460(7256):748-52
pubmed: 19571811
Nat Rev Immunol. 2013 May;13(5):321-35
pubmed: 23618829
Med Hypotheses. 2005;65(2):287-95
pubmed: 15885924
Nutrients. 2020 Oct 06;12(10):
pubmed: 33036205
Sci Rep. 2019 Nov 8;9(1):16323
pubmed: 31704943
Physiol Rev. 2019 Oct 1;99(4):1877-2013
pubmed: 31460832
Cell Mol Neurobiol. 2019 Jan;39(1):31-59
pubmed: 30446950
Cell. 2015 Apr 9;161(2):264-76
pubmed: 25860609
Microb Ecol. 2011 Apr;61(3):473-85
pubmed: 21222211
Cell. 2018 Oct 18;175(3):665-678.e23
pubmed: 30245012
Nat Genet. 2016 Nov;48(11):1407-1412
pubmed: 27694959
Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G779-84
pubmed: 16227525
Annu Rev Pathol. 2013 Jan 24;8:477-512
pubmed: 23157335
Curr Nutr Rep. 2019 Jun;8(2):83-91
pubmed: 31001792
Psychiatr Q. 1961 Apr;35:306-13
pubmed: 13707687
Psychiatr Q. 1953 Oct;27(4):663-81
pubmed: 13112324
Nutrients. 2019 Sep 06;11(9):
pubmed: 31489949
Heliyon. 2020 Jun 03;6(6):e04097
pubmed: 32529075
Biol Psychiatry. 2014 Feb 15;75(4):276-83
pubmed: 24199664
Curr Pharm Des. 2016;22(40):6122-6133
pubmed: 27604609
Nutrients. 2015 Nov 27;7(12):9768-84
pubmed: 26633470
Psychopharmacology (Berl). 2019 May;236(5):1611-1622
pubmed: 31098656
Nutrition. 2008 Apr;24(4):348-59
pubmed: 18262391
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 15;988:59-65
pubmed: 25746753
Infant Ment Health J. 2021 Jul;42(4):586-602
pubmed: 34021614
J Sci Food Agric. 2011 Jun;91(8):1341-8
pubmed: 21445871
Eur Arch Psychiatry Clin Neurosci. 2014 Dec;264(8):651-60
pubmed: 24705634
J ECT. 2014 Mar;30(1):47-61
pubmed: 23845938
Scand J Gastroenterol. 2008;43(4):410-5
pubmed: 18365905
Stress. 2019 Sep;22(5):592-602
pubmed: 31124390
Scand J Gastroenterol. 1997 Oct;32(10):1013-21
pubmed: 9361174
J Psychiatr Res. 2013 Mar;47(3):337-42
pubmed: 23207113
J Autoimmun. 2010 May;34(3):J220-5
pubmed: 19963349
Biomol Ther (Seoul). 2012 Mar;20(2):152-7
pubmed: 24116288
Eur Eat Disord Rev. 2010 Mar;18(2):116-23
pubmed: 20148396
Rev Neurosci. 2018 Aug 28;29(6):629-643
pubmed: 29397391
J Med Microbiol. 1982 May;15(2):189-203
pubmed: 7143428
World J Gastroenterol. 2016 Jan 7;22(1):361-8
pubmed: 26755882
Physiol Rev. 2010 Jul;90(3):859-904
pubmed: 20664075
Neurogastroenterol Motil. 2011 Mar;23(3):255-64, e119
pubmed: 21054680
J Physiol. 2004 Jul 1;558(Pt 1):263-75
pubmed: 15133062
PLoS One. 2015 Jun 02;10(6):e0128669
pubmed: 26035837
Nutr Rev. 2018 Aug 1;76(8):603-617
pubmed: 29718511
Scand J Gastroenterol. 2001 May;36(5):502-6
pubmed: 11346203
Aliment Pharmacol Ther. 2004 Oct 1;20(7):777-82
pubmed: 15379838
J Pediatr Gastroenterol Nutr. 2010 Jul;51(1):77-84
pubmed: 20479681
Gut Microbes. 2020;11(2):135-157
pubmed: 31368397
Front Endocrinol (Lausanne). 2021 Apr 19;12:613983
pubmed: 33953692
Oxid Med Cell Longev. 2017;2017:2473495
pubmed: 28855976
FEMS Microbiol Rev. 2020 Nov 24;44(6):763-781
pubmed: 32821932
J Affect Disord. 2014 Sep;166:187-92
pubmed: 25012430
J Transl Med. 2017 Apr 8;15(1):73
pubmed: 28388917
Glia. 2003 Sep;43(3):281-91
pubmed: 12898707
Front Neuroendocrinol. 2019 Oct;55:100797
pubmed: 31574280
Microorganisms. 2021 Mar 31;9(4):
pubmed: 33807290
Psychosom Med. 2021 Sep 1;83(7):679-692
pubmed: 34117156
Brain Res. 2011 Feb 10;1373:101-9
pubmed: 21146506
Curr Opin Clin Nutr Metab Care. 2011 Sep;14(5):477-82
pubmed: 21832903
Oxid Med Cell Longev. 2013;2013:104024
pubmed: 24089628
Transl Psychiatry. 2019 Feb 12;9(1):87
pubmed: 30755592
Toxicol Pathol. 2012;40(2):216-29
pubmed: 22105648
Nutrients. 2018 May 08;10(5):
pubmed: 29738477
Appl Environ Microbiol. 2006 Jul;72(7):5097-9
pubmed: 16820514
Mikrobiologiia. 2016;86(1):5-24
pubmed: 30207138