DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation.
CP: Immunology
CP: Molecular biology
DNA damage
DNA methylation
chronic kidney disease
podocyte
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
25 04 2023
25 04 2023
Historique:
received:
09
09
2022
revised:
03
01
2023
accepted:
06
03
2023
medline:
4
10
2023
pubmed:
30
3
2023
entrez:
29
3
2023
Statut:
ppublish
Résumé
Recent epigenome-wide studies suggest an association between blood DNA methylation and kidney function. However, the pathological importance remains unclear. Here, we show that the homing endonuclease I-PpoI-induced DNA double-strand breaks in kidney glomerular podocytes cause proteinuria, glomerulosclerosis, and tubulointerstitial fibrosis with DNA methylation changes in blood cells as well as in podocytes. Single-cell RNA-sequencing analysis reveals an increase in cytotoxic CD8
Identifiants
pubmed: 36989112
pii: S2211-1247(23)00313-3
doi: 10.1016/j.celrep.2023.112302
pii:
doi:
Substances chimiques
NK Cell Lectin-Like Receptor Subfamily K
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112302Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.