Timing and frequency of oropharyngeal squamous cell carcinoma recurrences after treatment with curative intent.

Humans Squamous Cell Carcinoma of Head and Neck Oropharyngeal Neoplasms / therapy Carcinoma, Squamous Cell / pathology Head and Neck Neoplasms / complications Finland Papillomavirus Infections / complications Prognosis Retrospective Studies
Oropharynx cancer follow-up head and neck human papilloma virus squamous cell carcinoma

Journal

Acta oto-laryngologica
ISSN: 1651-2251
Titre abrégé: Acta Otolaryngol
Pays: England
ID NLM: 0370354

Informations de publication

Date de publication:
Apr 2023
Historique:
medline: 3 5 2023
pubmed: 31 3 2023
entrez: 30 3 2023
Statut: ppublish

Résumé

The increasing number of patients under surveillance after treatment of human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC) places a great burden on healthcare providers. The aim of this study was to explore OPSCC recurrences in a long follow-up period: their site, frequency and timepoint after primary treatment, treatment and outcome. The secondary aim was to investigate if the recurrences are diagnosed on routine follow-up visits, and if the p16 status will have an effect on the pattern of recurrences. We analyzed recurrences within a 10-year follow-up period after completed curatively intended treatment among OPSCC patients in Finland treated between 2000 and 2009. Patient-, tumor-, treatment- and follow-up -related parameters were investigated. Out of 495 patients with no residual tumor during the first six months, 71 (14%) were diagnosed with a recurrence, of which 47 were locoregional and 28 were treated with curative intent. Of the recurrences, 86% were diagnosed during the first 36 months after primary treatment. Only ten recurrences appeared after 36 months. The median OS after recurrence was 10.9 months. Routine follow-up longer than three years after treatment seems not to be effective in terms of detecting OPSCC recurrences.

Sections du résumé

BACKGROUND UNASSIGNED
The increasing number of patients under surveillance after treatment of human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC) places a great burden on healthcare providers.
AIMS/OBJECTIVES UNASSIGNED
The aim of this study was to explore OPSCC recurrences in a long follow-up period: their site, frequency and timepoint after primary treatment, treatment and outcome. The secondary aim was to investigate if the recurrences are diagnosed on routine follow-up visits, and if the p16 status will have an effect on the pattern of recurrences.
MATERIAL AND METHODS UNASSIGNED
We analyzed recurrences within a 10-year follow-up period after completed curatively intended treatment among OPSCC patients in Finland treated between 2000 and 2009. Patient-, tumor-, treatment- and follow-up -related parameters were investigated.
RESULTS UNASSIGNED
Out of 495 patients with no residual tumor during the first six months, 71 (14%) were diagnosed with a recurrence, of which 47 were locoregional and 28 were treated with curative intent. Of the recurrences, 86% were diagnosed during the first 36 months after primary treatment. Only ten recurrences appeared after 36 months. The median OS after recurrence was 10.9 months.
CONCLUSIONS AND SIGNIFICANCE UNASSIGNED
Routine follow-up longer than three years after treatment seems not to be effective in terms of detecting OPSCC recurrences.

Identifiants

DOI: 10.1080/00016489.2023.2188892 PMID: 36994865
pubmed: 36994865
doi: 10.1080/00016489.2023.2188892
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

328-333

Auteurs

Timo J Autio (TJ)

Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Oulu, Finland.
PEDEGO Research Unit, University of Oulu, Oulu, Finland.
Medical Research Center Oulu, Oulu, Finland.

Timo Atula (T)

Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Lauri Jouhi (L)

Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Heikki Irjala (H)

Department of Otorhinolaryngology and Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, Finland.

Elina Halme (E)

Department of Otorhinolaryngology-Head and Neck Surgery, Tampere University Hospital, Tampere, Finland.

Anna Jouppila-Mättö (A)

Department of Otorhinolaryngology- Head and Neck Surgery, Kuopio University Hospital, Kuopio, Finland.

Antti Mäkitie (A)

Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.

Petri Koivunen (P)

Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Oulu, Finland.
PEDEGO Research Unit, University of Oulu, Oulu, Finland.
Medical Research Center Oulu, Oulu, Finland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Timing and frequency of oropharyngeal squamous...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › Timing and frequency of oropharyngeal squamous...
questionsmedicales.fr › Maladies oto-rhino-laryngologiques › Maladies du pharynx › Tumeurs du pharynx › Tumeurs de l'oropharynx › Timing and frequency of oropharyngeal squamous...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Timing and frequency of oropharyngeal squamous...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Timing and frequency of oropharyngeal squamous...
questionsmedicales.fr › Régions géographiques › Europe › Pays nordiques et scandinaves › Finlande › Timing and frequency of oropharyngeal squamous...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladies transmissibles › Maladies sexuellement transmissibles › Maladies sexuellement transmissibles virales › Infections à papillomavirus › Timing and frequency of oropharyngeal squamous...
questionsmedicales.fr › Diagnostic › Pronostic › Timing and frequency of oropharyngeal squamous...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Timing and frequency of oropharyngeal squamous...