A Data-Driven Approach to Estimating Occupational Inhalation Exposure Using Workplace Compliance Data.


Journal

Environmental science & technology
ISSN: 1520-5851
Titre abrégé: Environ Sci Technol
Pays: United States
ID NLM: 0213155

Informations de publication

Date de publication:
11 04 2023
Historique:
medline: 12 4 2023
pubmed: 31 3 2023
entrez: 30 3 2023
Statut: ppublish

Résumé

A growing list of chemicals are approved for production and use in the United States and elsewhere, and new approaches are needed to rapidly assess the potential exposure and health hazard posed by these substances. Here, we present a high-throughput, data-driven approach that will aid in estimating occupational exposure using a database of over 1.5 million observations of chemical concentrations in U.S. workplace air samples. We fit a Bayesian hierarchical model that uses industry type and the physicochemical properties of a substance to predict the distribution of workplace air concentrations. This model substantially outperforms a null model when predicting whether a substance will be detected in an air sample, and if so at what concentration, with 75.9% classification accuracy and a root-mean-square error (RMSE) of 1.00 log

Identifiants

pubmed: 36995295
doi: 10.1021/acs.est.2c08234
pmc: PMC10100548
doi:

Substances chimiques

Air Pollutants, Occupational 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5947-5956

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Auteurs

Jeffrey M Minucci (JM)

Center for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 TW Alexander Drive, Durham, North Carolina 27709, United States.

S Thomas Purucker (ST)

Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, 109 TW Alexander Drive, Durham, North Carolina 27709, United States.

Kristin K Isaacs (KK)

Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, 109 TW Alexander Drive, Durham, North Carolina 27709, United States.

John F Wambaugh (JF)

Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, 109 TW Alexander Drive, Durham, North Carolina 27709, United States.

Katherine A Phillips (KA)

Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, 109 TW Alexander Drive, Durham, North Carolina 27709, United States.

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Classifications MeSH