Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery.

Humans Child Bupivacaine Prospective Studies Pain, Postoperative / drug therapy Anesthetics, Local Analgesics

Journal

Urology
ISSN: 1527-9995
Titre abrégé: Urology
Pays: United States
ID NLM: 0366151

Informations de publication

Date de publication:
Jun 2023
Historique:
received: 11 12 2022
revised: 19 01 2023
accepted: 30 01 2023
medline: 26 6 2023
pubmed: 31 3 2023
entrez: 30 3 2023
Statut: ppublish

Résumé

This study evaluates the tolerability and efficacy of preoperative dorsal penile nerve block with Exparel plus bupivacaine hydrochloride in children>6 years old undergoing ambulatory urologic surgery. We demonstrate that the drug combination is well-tolerated, with appropriate analgesic efficacy in the recovery room as well as at 48-hour and 10-14 day follow-up periods. These preliminary data justify the need to perform a prospective, randomized trial comparing Exparel plus bupivacaine hydrochloride to other common local anesthetic regimens used in pediatric urologic surgery.

Identifiants

DOI: 10.1016/j.urology.2023.01.056 PMID: 36997075
pubmed: 36997075
pii: S0090-4295(23)00272-8
doi: 10.1016/j.urology.2023.01.056
pii:
doi:

Substances chimiques

Bupivacaine Y8335394RO
Anesthetics, Local 0
Analgesics 0

Types de publication

Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

190-193

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Andrew T Gabrielson (AT)

Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD. Electronic address: agabrie7@jhmi.edu.

Logan Galansky (L)

Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD.

Tamir Sholklapper (T)

Albert Einstein Medical Center, Philadelphia, PA.

Isabella Florissi (I)

Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD.

Chad Crigger (C)

Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD.

Kelly Harris (K)

University of Colorado School of Medicine, Aurora, CO.

Nora Haney (N)

Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD.

Hiten D Patel (HD)

Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Ming-Hsien Wang (MH)

Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD.

Charlotte Wu (C)

Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD.

John P Gearhart (JP)

Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD.

Heather N Di Carlo (HN)

Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Safety and Efficacy of Long-Acting Liposomal...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Safety and Efficacy of Long-Acting Liposomal...
questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Anilides › Bupivacaïne › Safety and Efficacy of Long-Acting Liposomal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Safety and Efficacy of Long-Acting Liposomal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Douleur postopératoire › Safety and Efficacy of Long-Acting Liposomal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Anesthésiques › Anesthésiques locaux › Safety and Efficacy of Long-Acting Liposomal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Safety and Efficacy of Long-Acting Liposomal...