CD99 and NKX2.2 positive neuroblastoma diagnosed on cytology: A potential diagnostic pitfall and necessity of pathological evaluation of the primary site.
CD99 positive
NKX2.2 positive neuroblastoma
neuroblastoma
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
revised:
25
02
2023
received:
28
10
2022
accepted:
27
02
2023
medline:
3
5
2023
pubmed:
1
4
2023
entrez:
31
3
2023
Statut:
ppublish
Résumé
Immunohistochemistry plays a vital role in the diagnosis of small round cell tumors. CD99 immunonegativity is one of the features, which helps in distinguishing neuroblastoma from other small round cell tumors. NKX2.2 is a specific marker of Ewing sarcoma, which is a differential for poorly differentiated neuroblastoma. Here, we present a case of metastatic neuroblastoma showing immunoreactivity for both CD99 and NKX2.2 on cytology of the metastatic site causing diagnostic dilemma. Biopsy study of the adrenal lesion revealed presence of differentiating cells and neuropil, highlighting the importance of evaluation of the primary site and limitation of cytology.
Substances chimiques
Transcription Factors
0
Homeobox Protein Nkx-2.2
0
Homeodomain Proteins
0
Nuclear Proteins
0
Biomarkers, Tumor
0
CD99 protein, human
0
12E7 Antigen
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
E189-E194Informations de copyright
© 2023 Wiley Periodicals LLC.
Références
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