Sex Differences in the Impact of Electronic Nicotine Vapor on Corticotropin-Releasing Factor Receptor 1 Neurons in the Mouse Ventral Tegmental Area.
CRF1
ENDS
VTA
dopamine
nicotine
vapor
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
26 04 2023
26 04 2023
Historique:
received:
09
11
2022
revised:
21
03
2023
accepted:
23
03
2023
medline:
17
5
2023
pubmed:
1
4
2023
entrez:
31
3
2023
Statut:
ppublish
Résumé
Nicotine engages dopamine neurons in the ventral tegmental area (VTA) to encode reward and drive the development of nicotine addiction, however how nicotine alters a stress associated VTA population remains unclear. Here, we used male and female CRF1-GFP mice and nicotine vapor exposure to examine the effects of nicotine in VTA corticotropin-releasing factor receptor 1 (CRF1) neurons. We use immunohistochemistry and electrophysiology to examine neuronal activity, excitability, and inhibitory signaling. We found that VTA CRF1 neurons are mainly dopaminergic and project to the nucleus accumbens (NAc;
Identifiants
pubmed: 37001989
pii: JNEUROSCI.2087-22.2023
doi: 10.1523/JNEUROSCI.2087-22.2023
pmc: PMC10146490
doi:
Substances chimiques
Nicotine
6M3C89ZY6R
CRF receptor type 1
5CLY6W2H1M
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3081-3093Subventions
Organisme : NIAAA NIH HHS
ID : P60 AA011605
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50 AA011605
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS007431
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026858
Pays : United States
Organisme : NIDA NIH HHS
ID : F31 DA053064
Pays : United States
Informations de copyright
Copyright © 2023 the authors.