DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous
DNA vaccine
Lyme borreliosis
Lyme disease
antibodies
carditis
lipid nanoparticle
lymphadenopathy
outer surface protein C
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
15
08
2022
accepted:
03
03
2023
medline:
4
4
2023
entrez:
3
4
2023
pubmed:
4
4
2023
Statut:
epublish
Résumé
The incidence of Lyme disease (LD) in Canada and the United States has risen over the last decade, nearing 480,000 cases each year. In this study, we developed a lipid nanoparticle (LNP)-encapsulated DNA vaccine encoding outer surface protein C type A (OspC-type A) of Vaccination of C3H/HeN mice with two doses of the candidate vaccine induced significant OspC-type A-specific antibody titres and borreliacidal activity. Analysis of the bacterial burden following needle challenge with Overall, the results of this study provide support for the use of a DNA-LNP platform for the development of LD vaccines.
Identifiants
pubmed: 37006299
doi: 10.3389/fimmu.2023.1020134
pmc: PMC10060826
doi:
Substances chimiques
OspC protein
0
Vaccines, DNA
0
Lipid Nanoparticles
0
Bacterial Vaccines
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1020134Subventions
Organisme : CIHR
ID : PJT-153336
Pays : Canada
Informations de copyright
Copyright © 2023 Pfeifle, Thulasi Raman, Lansdell, Zhang, Tamming, Cecillon, Laryea, Patel, Wu, Gravel, Frahm, Gao, Chen, Chaconas, Sauve, Rosu-Myles, Wang, Johnston and Li.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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