Microbiome modulation after severe acute kidney injury accelerates functional recovery and decreases kidney fibrosis.

Animals Mice Acute Kidney Injury / chemically induced Kidney / pathology Reperfusion Injury / pathology Ischemia Fibrosis Microbiota Amoxicillin / adverse effects
acute kidney injury amoxicillin glomerular filtration rate gut bacteria kidney repair microbiome

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
09 2023
Historique:
received: 07 10 2022
revised: 02 03 2023
accepted: 17 03 2023
medline: 22 8 2023
pubmed: 4 4 2023
entrez: 3 4 2023
Statut: ppublish

Résumé

Targeting gut microbiota has shown promise to prevent experimental acute kidney injury (AKI). However, this has not been studied in relation to accelerating recovery and preventing fibrosis. Here, we found that modifying gut microbiota with an antibiotic administered after severe ischemic kidney injury in mice, particularly with amoxicillin, accelerated recovery. These indices of recovery included increased glomerular filtration rate, diminution of kidney fibrosis, and reduction of kidney profibrotic gene expression. Amoxicillin was found to increase stool Alistipes, Odoribacter and Stomatobaculum species while significantly depleting Holdemanella and Anaeroplasma. Specifically, amoxicillin treatment reduced kidney CD4

Identifiants

DOI: 10.1016/j.kint.2023.03.024 PMID: 37011727
pubmed: 37011727
pii: S0085-2538(23)00234-X
doi: 10.1016/j.kint.2023.03.024
pii:
doi:

Substances chimiques

Amoxicillin 804826J2HU

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

470-491

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK123342
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104662
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2023 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Auteurs

Sepideh Gharaie (S)

Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Kyungho Lee (K)

Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Andrea M Newman-Rivera (AM)

Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Jiaojiao Xu (J)

Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Shishir Kumar Patel (SK)

Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Mahta Gooya (M)

Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Lois J Arend (LJ)

Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Dominic S Raj (DS)

Department of Medicine, George Washington University, School of Medicine and Health Sciences, Washington, District of Columbia, USA.

Jennifer Pluznick (J)

Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Chirag Parikh (C)

Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Sanjeev Noel (S)

Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Hamid Rabb (H)

Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA. Electronic address: hrabb1@jhmi.edu.

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Classifications MeSH

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questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Lésion d'ischémie-reperfusion › Microbiome modulation after severe acute...
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