Can accelerated ageing models inform us on age-related tauopathies?
ageing
animal models
progeria
tau
tauopathy
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
revised:
17
03
2023
received:
16
01
2023
accepted:
20
03
2023
medline:
17
5
2023
pubmed:
5
4
2023
entrez:
4
4
2023
Statut:
ppublish
Résumé
Ageing is the greatest risk factor of late-onset neurodegenerative diseases. In the realm of sporadic tauopathies, modelling the process of biological ageing in experimental animals forms the foundation of searching for the molecular origin of pathogenic tau and developing potential therapeutic interventions. Although prior research into transgenic tau models offers valuable lessons for studying how tau mutations and overexpression can drive tau pathologies, the underlying mechanisms by which ageing leads to abnormal tau accumulation remains poorly understood. Mutations associated with human progeroid syndromes have been proposed to be able to mimic an aged environment in animal models. Here, we summarise recent attempts in modelling ageing in relation to tauopathies using animal models that carry mutations associated with human progeroid syndromes, or genetic elements unrelated to human progeroid syndromes, or have exceptional natural lifespans, or a remarkable resistance to ageing-related disorders.
Identifiants
pubmed: 37013265
doi: 10.1111/acel.13830
pmc: PMC10186612
doi:
Substances chimiques
tau Proteins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13830Subventions
Organisme : Wellcome Trust and the Royal Society
ID : 206242/Z/17/Z
Informations de copyright
© 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
Références
Eur J Neurosci. 2008 Jul;28(2):239-46
pubmed: 18702695
Annu Rev Genomics Hum Genet. 2009;10:153-74
pubmed: 19453251
Proc Natl Acad Sci U S A. 1988 Jun;85(11):4051-5
pubmed: 3131773
Acta Neuropathol. 2020 Jun;139(6):1045-1070
pubmed: 32219515
Elife. 2018 Jan 24;7:
pubmed: 29364116
Science. 2005 Jul 15;309(5733):476-81
pubmed: 16020737
Gastroenterology. 2021 Jan;160(2):507-523
pubmed: 33307030
Int J Prev Med. 2013 Jun;4(6):624-30
pubmed: 23930179
Nature. 2020 Jul;583(7814):E1-E7
pubmed: 32612221
Aging Cell. 2023 May;22(5):e13830
pubmed: 37013265
J Neurol. 2003 Oct;250(10):1174-8
pubmed: 14586597
Neurobiol Aging. 2013 Oct;34(10):2352-60
pubmed: 23618870
J Intern Med. 2008 Feb;263(2):167-78
pubmed: 18226094
Neurobiol Aging. 2012 Jul;33(7):1448-56
pubmed: 21196063
EMBO Rep. 2016 Apr;17(4):530-51
pubmed: 26931567
Front Mol Neurosci. 2021 Jan 25;13:610037
pubmed: 33568975
Brain. 2016 Aug;139(Pt 8):2290-306
pubmed: 27297240
Geroscience. 2021 Oct;43(5):2441-2453
pubmed: 34487267
J Cell Biol. 1993 Apr;121(2):257-67
pubmed: 8468346
Oncotarget. 2017 Nov 30;8(66):109941-109951
pubmed: 29299120
Aging (Albany NY). 2012 Mar;4(3):166-75
pubmed: 22411934
J Neurosci. 2015 Feb 11;35(6):2358-71
pubmed: 25673831
eNeuro. 2020 May 28;7(3):
pubmed: 32393582
Cancer Cell Int. 2019 Sep 10;19:237
pubmed: 31516394
J Biol Chem. 2019 Aug 23;294(34):12754-12765
pubmed: 31273083
PLoS One. 2013 Jul 05;8(7):e68361
pubmed: 23861893
Hum Mol Genet. 2015 May 15;24(10):2826-40
pubmed: 25652409
Science. 2013 Mar 29;339(6127):1604-7
pubmed: 23539603
Ageing Res Rev. 2017 Jan;33:105-114
pubmed: 26993153
PLoS One. 2016 Dec 1;11(12):e0167454
pubmed: 27907109
Oncogene. 2005 Jan 13;24(3):469-78
pubmed: 15558025
Nutrition. 2005 Jun;21(6):775-7
pubmed: 15925305
J Biol Chem. 2011 Feb 11;286(6):4566-75
pubmed: 21131359
Epigenomics. 2022 Sep;14(18):1125-1138
pubmed: 36154448
Elife. 2021 Nov 01;10:
pubmed: 34723800
Int J Mol Sci. 2019 Feb 18;20(4):
pubmed: 30781626
Brain Behav Immun. 2018 Oct;73:450-469
pubmed: 29908963
Neurology. 2000 Jun 13;54(11):2072-7
pubmed: 10851365
Nutrients. 2021 Mar 18;13(3):
pubmed: 33803798
Cell. 2023 Jan 19;186(2):243-278
pubmed: 36599349
Nature. 2021 Apr;592(7856):695-703
pubmed: 33911272
Age (Dordr). 2015 Feb;37(1):9747
pubmed: 25663420
Genes (Basel). 2021 Dec 30;13(1):
pubmed: 35052436
EBioMedicine. 2017 Jul;21:29-36
pubmed: 28396265
Nat Med. 2014 Aug;20(8):870-80
pubmed: 25100532
Curr Biol. 2016 Jan 11;26(1):129-36
pubmed: 26725200
Cell Rep. 2012 Jul 26;2(1):1-9
pubmed: 22840390
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):
pubmed: 35197292
Orphanet J Rare Dis. 2016 Nov 25;11(1):159
pubmed: 27884168
Science. 2017 Apr 21;356(6335):307-311
pubmed: 28428423
J Epidemiol Glob Health. 2020 Mar;10(1):107-111
pubmed: 32175717
Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8656-61
pubmed: 15939880
Brain. 2008 Aug;131(Pt 8):1979-89
pubmed: 18567921
J Neurosci. 2008 Jan 16;28(3):737-48
pubmed: 18199773
J Biol Chem. 2005 Feb 4;280(5):3963-73
pubmed: 15509565
Pediatr Allergy Immunol. 2019 May;30(3):277-288
pubmed: 30685876
Mech Ageing Dev. 2013 May-Jun;134(5-6):161-70
pubmed: 23428416
Front Cell Neurosci. 2014 Mar 18;8:84
pubmed: 24672431
Elife. 2022 Mar 04;11:
pubmed: 35244536
Nucleic Acids Res. 2020 Nov 4;48(19):10973-10985
pubmed: 33021672
Am J Prev Med. 2014 Mar;46(3 Suppl 1):S7-15
pubmed: 24512933
J Neurosci. 2002 Nov 1;22(21):9340-51
pubmed: 12417659
Front Mol Biosci. 2021 May 17;8:660959
pubmed: 34079817
J Cell Biol. 1985 Oct;101(4):1371-8
pubmed: 3930508
Aging (Albany NY). 2015 Dec;7(12):1198-211
pubmed: 26684672
Am J Pathol. 2013 Jul;183(1):211-25
pubmed: 23680655
Physiol Behav. 1986;38(3):399-406
pubmed: 3786521
Mol Cell Biol. 2011 May;31(9):1812-21
pubmed: 21343338
J Biol Chem. 2007 Oct 26;282(43):31755-65
pubmed: 17716969
PLoS One. 2015 Mar 24;10(3):e0121570
pubmed: 25803611
J Physiol Biochem. 2019 Jun;75(2):229-240
pubmed: 30927227
Nat Commun. 2017 Aug 30;8(1):328
pubmed: 28855503
Commun Biol. 2022 Apr 13;5(1):358
pubmed: 35418705
Cells. 2019 Feb 08;8(2):
pubmed: 30744037
Cell. 1995 Aug 25;82(4):555-64
pubmed: 7664335
J Neurosurg. 2012 Jun;116(6):1368-78
pubmed: 22462511
Cells. 2021 Jun 28;10(7):
pubmed: 34203326
Cell Tissue Res. 2023 Apr;392(1):179-199
pubmed: 35460367
Life Sci. 2016 May 1;152:244-8
pubmed: 26596563
JAMA Netw Open. 2022 Nov 1;5(11):e2243232
pubmed: 36413367
Neuropathol Appl Neurobiol. 2015 Feb;41(1):3-23
pubmed: 25495175
PLoS One. 2008;3(12):e3866
pubmed: 19052641
Genome Biol. 2017 Apr 11;18(1):68
pubmed: 28399939
Neuron. 2014 Jun 18;82(6):1271-88
pubmed: 24857020
Nucleic Acids Res. 2022 Sep 9;50(16):9260-9278
pubmed: 36039758
Mech Ageing Dev. 1997 Dec;98(3):239-54
pubmed: 9352493
Nature. 2005 Sep 22;437(7058):564-8
pubmed: 16079796
Biochemistry. 2022 Jul 5;61(13):1243-1259
pubmed: 35731895
Orphanet J Rare Dis. 2011 Nov 01;6:70
pubmed: 22044607
Biol Sex Differ. 2022 Nov 22;13(1):68
pubmed: 36414996
Dev Dyn. 2012 Jun;241(6):1133-41
pubmed: 22473915
PLoS Genet. 2014 Oct 09;10(10):e1004686
pubmed: 25299392
Nature. 2013 Jul 18;499(7458):346-9
pubmed: 23783513
FASEB J. 2003 Jan;17(1):50-2
pubmed: 12475907
Cell Rep. 2022 Aug 23;40(8):111249
pubmed: 36001963
J Neurosci. 2011 Aug 31;31(35):12543-53
pubmed: 21880916
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):E423-31
pubmed: 22308344
Brain Res Dev Brain Res. 2003 May 14;142(2):121-7
pubmed: 12711363
Aging Cell. 2012 Apr;11(2):360-2
pubmed: 22181010
Hum Genet. 2008 Nov;124(4):369-77
pubmed: 18810497
Acta Neuropathol Commun. 2015 Jun 04;3:33
pubmed: 26041339
BMC Neurosci. 2013 Nov 22;14:148
pubmed: 24261309
JAMA Neurol. 2013 Jul;70(7):859-66
pubmed: 23689920
Gerontology. 2009;55(4):430-41
pubmed: 19654474
Nat Protoc. 2016 Oct;11(10):2010-2028
pubmed: 27658015
Sci Rep. 2021 Aug 5;11(1):15929
pubmed: 34354164
J Cell Biol. 2013 May 13;201(4):541-57
pubmed: 23649804
J Cardiovasc Dev Dis. 2019 Apr 27;6(2):
pubmed: 31035613
Sci Rep. 2019 Nov 29;9(1):17904
pubmed: 31784610
Int J Mol Sci. 2020 May 06;21(9):
pubmed: 32384696
Sci Rep. 2016 Apr 21;6:24756
pubmed: 27099072
Life Sci Alliance. 2022 Oct 31;6(1):
pubmed: 36316035
Cell Death Dis. 2022 Jan 10;13(1):48
pubmed: 35013124
Alzheimers Dement (Amst). 2020 Apr 09;12(1):e12016
pubmed: 32280740
Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8963-8
pubmed: 15184648
Continuum (Minneap Minn). 2019 Feb;25(1):14-33
pubmed: 30707185
Pathobiol Aging Age Relat Dis. 2011;1:
pubmed: 22953029
Biochim Biophys Acta. 2009 Oct;1790(10):1049-58
pubmed: 19230844
Br J Ophthalmol. 2004 Aug;88(8):989-94
pubmed: 15258010
Am J Pathol. 2006 Aug;169(2):599-616
pubmed: 16877359
J Neurosci. 2019 Sep 18;39(38):7628-7640
pubmed: 31405930
FEBS Lett. 2006 Jun 26;580(15):3582-8
pubmed: 16753151
Nature. 1995 Sep 14;377(6545):169-73
pubmed: 7675086
Cell. 2015 Dec 3;163(6):1539-54
pubmed: 26638078
Mol Neurodegener. 2017 Oct 4;12(1):72
pubmed: 28978354
Cell Stem Cell. 2013 Dec 5;13(6):691-705
pubmed: 24315443
Exp Gerontol. 1997 Jan-Apr;32(1-2):139-48
pubmed: 9088911
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13896-901
pubmed: 12368474
Pediatr Dev Pathol. 2022 May-Jun;25(3):327-329
pubmed: 34961372
Nature. 1995 Sep 14;377(6545):165-8
pubmed: 7675085
Biol Sex Differ. 2020 Jun 19;11(1):33
pubmed: 32560743
Mol Cell Biol. 1989 Apr;9(4):1389-96
pubmed: 2498650
JAMA Neurol. 2020 Jul 1;77(7):849-862
pubmed: 32282020
Cell. 2010 Jul 9;142(1):9-14
pubmed: 20603007
Front Neurol. 2021 Jun 17;12:571800
pubmed: 34220661
Neurobiol Aging. 2015 Mar;36(3):1496-504
pubmed: 25576082
Cell Rep. 2019 Oct 22;29(4):800-809.e5
pubmed: 31644904
Nat Commun. 2021 Jun 22;12(1):3825
pubmed: 34158479
Neuron. 1989 Oct;3(4):519-26
pubmed: 2484340
Aging Cell. 2010 Aug;9(4):626-35
pubmed: 20550519
Hum Mol Genet. 2015 Mar 1;24(5):1305-21
pubmed: 25343989
Cell Rep. 2019 Jan 15;26(3):582-593.e5
pubmed: 30650353
Nat Rev Neurol. 2019 Oct;15(10):565-581
pubmed: 31501588
Hum Mol Genet. 2012 Sep 15;21(18):4084-93
pubmed: 22718200
Nat Commun. 2018 Nov 19;9(1):4859
pubmed: 30451844
Sci Adv. 2022 Dec 14;8(50):eade0764
pubmed: 36516243
Cancer Cell. 2006 Aug;10(2):121-32
pubmed: 16904611
Acta Neuropathol Commun. 2019 May 17;7(1):77
pubmed: 31101070
Cell. 1992 Dec 11;71(6):939-53
pubmed: 1339317
Mol Psychiatry. 2022 Dec;27(12):5213-5226
pubmed: 36028572
Am J Med Genet A. 2011 Nov;155A(11):2617-25
pubmed: 21932319
Proc Natl Acad Sci U S A. 1975 May;72(5):1858-62
pubmed: 1057175
Nat Commun. 2013;4:2300
pubmed: 23939249
Annu Rev Pathol. 2022 Jan 24;17:159-180
pubmed: 34672689
Behav Brain Res. 2014 Sep 1;271:79-88
pubmed: 24925454
Nat Rev Drug Discov. 2015 Oct;14(10):721-31
pubmed: 26361349
Neuropathology. 2017 Aug;37(4):293-305
pubmed: 28261874
J Neuroinflammation. 2021 Mar 18;18(1):75
pubmed: 33736657
Int J Mol Sci. 2020 Mar 07;21(5):
pubmed: 32155994
Acta Neuropathol. 2018 Oct;136(4):525-536
pubmed: 30074071
Neurobiol Dis. 2016 Mar;87:19-28
pubmed: 26704708
Orphanet J Rare Dis. 2021 Feb 3;16(1):63
pubmed: 33536051
Neurochem Res. 2000 Jan;25(1):43-50
pubmed: 10685603
Clin Genet. 2004 Nov;66(5):375-81
pubmed: 15479179
Cell Rep. 2018 May 8;23(6):1612-1619
pubmed: 29742419
Mol Cell. 1998 Jun;1(7):981-90
pubmed: 9651581
Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22173-22178
pubmed: 31619571
Am J Physiol Regul Integr Comp Physiol. 2020 Apr 1;318(4):R712-R721
pubmed: 31967860
Aging Dis. 2019 Apr 1;10(2):367-382
pubmed: 31011483
Physiol Rev. 2008 Apr;88(2):557-79
pubmed: 18391173
DNA Repair (Amst). 2013 Dec;12(12):1081-6
pubmed: 24084170
Elife. 2017 Aug 22;6:
pubmed: 28826469
Aging (Albany NY). 2020 Oct 20;12(20):20817-20834
pubmed: 33082299
Mol Cell Biol. 2011 Aug;31(16):3378-95
pubmed: 21670151
Alzheimers Res Ther. 2020 Jun 8;12(1):70
pubmed: 32513253
Nature. 1997 Nov 6;390(6655):45-51
pubmed: 9363890
Neuron. 2007 Feb 1;53(3):337-51
pubmed: 17270732
Mol Cell Biol. 2009 Mar;29(5):1276-90
pubmed: 19114557
Int J Mol Sci. 2020 Feb 28;21(5):
pubmed: 32121304
Sci Transl Med. 2011 Oct 26;3(106):106ra107
pubmed: 22030750
Semin Hematol. 2013 Apr;50(2):165-74
pubmed: 23956466
Acta Neuropathol. 2010 Oct;120(4):461-75
pubmed: 20602234
J Anat. 2008 Nov;213(5):509-19
pubmed: 19014358
J Alzheimers Dis. 2011;25(3):535-46
pubmed: 21460438
PLoS One. 2011;6(6):e14821
pubmed: 21731603
J Neurosci. 2002 Jan 1;22(1):133-41
pubmed: 11756496
Nat Rev Mol Cell Biol. 2021 Feb;22(2):75-95
pubmed: 33328614
Neuron. 2012 Feb 23;73(4):685-97
pubmed: 22365544
PLoS Genet. 2011 Dec;7(12):e1002405
pubmed: 22174697
Handb Clin Neurol. 2015;132:249-64
pubmed: 26564085
J Neurosci. 2004 May 12;24(19):4657-67
pubmed: 15140937
Lancet Neurol. 2020 Feb;19(2):145-156
pubmed: 31810826
Neurodegener Dis. 2013;11(4):194-205
pubmed: 22797329
Nat Genet. 2000 Aug;25(4):402-5
pubmed: 10932182
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13049-54
pubmed: 12235369
Cell Rep. 2017 Aug 8;20(6):1360-1371
pubmed: 28793260
J Alzheimers Dis. 2021;79(3):1297-1305
pubmed: 33427737
ILAR J. 2011;52(1):41-53
pubmed: 21411857
Elife. 2020 Nov 12;9:
pubmed: 33179594
J Neurochem. 2003 Aug;86(3):582-90
pubmed: 12859672
Physiol Behav. 1992 May;51(5):979-85
pubmed: 1615059
Ageing Res Rev. 2016 Mar;26:96-111
pubmed: 26835847
Annu Rev Pathol. 2019 Jan 24;14:239-261
pubmed: 30355155
Brief Bioinform. 2011 Sep;12(5):449-62
pubmed: 21873635
Neurosci Lett. 2021 Apr 1;749:135741
pubmed: 33610669
DNA Repair (Amst). 2008 Feb 1;7(2):281-91
pubmed: 18221731
Annu Rev Physiol. 2013;75:645-68
pubmed: 23398157