Structural and molecular insights into tacrine-benzofuran hybrid induced inhibition of amyloid-β peptide aggregation and BACE1 activity.
Alzheimer’s disease
BACE1
MD simulations
amyloid-β
tacrine-benzofuran hybrid
Journal
Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
27
11
2023
pubmed:
5
4
2023
entrez:
4
4
2023
Statut:
ppublish
Résumé
Amyloid-β (Aβ) aggregation and β-amyloid precursor protein cleaving enzyme 1 (BACE1) are the potential therapeutic drug targets for Alzheimer's disease (AD). A recent study highlighted that tacrine-benzofuran hybrid C1 displayed anti-aggregation activity against Aβ
Identifiants
pubmed: 37013977
doi: 10.1080/07391102.2023.2191722
doi:
Substances chimiques
Amyloid beta-Peptides
0
Amyloid beta-Protein Precursor
0
Tacrine
4VX7YNB537
Amyloid Precursor Protein Secretases
EC 3.4.-
Ligands
0
Aspartic Acid Endopeptidases
EC 3.4.23.-
Benzofurans
0
Peptide Fragments
0
BACE1 protein, human
EC 3.4.23.46
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM