questionsmedicales.fr
Composés hétérocycliques
Composés hétérocycliques à cycles fusionnés
Composés hétérocycliques 3 noyaux
Acridines
Aminoacridines
Tacrine
Tacrine : Questions médicales fréquentes
Diagnostic
2
Maladie d'Alzheimer
Acétylcholinestérase
Évaluation cognitive
Antécédents médicaux
Symptômes
2
Troubles de la mémoire
Démence
Maladie d'Alzheimer
Symptômes cognitifs
Prévention
2
Prévention
Maladie d'Alzheimer
Mode de vie sain
Exercices mentaux
Traitements
2
Administration orale
Comprimés
Effets secondaires
Nausées
Complications
2
Complications hépatiques
Suivi médical
Interactions médicamenteuses
Effets secondaires
Facteurs de risque
2
Antécédents médicaux
Maladies hépatiques
Vieillissement
Sensibilité aux médicaments
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Tacrine : Questions médicales les plus fréquentes",
"headline": "Tacrine : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Tacrine : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-03-03",
"dateModified": "2025-11-23",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Tacrine"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Aminoacridines",
"url": "https://questionsmedicales.fr/mesh/D000609",
"about": {
"@type": "MedicalCondition",
"name": "Aminoacridines",
"code": {
"@type": "MedicalCode",
"code": "D000609",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D03.633.300.046.250"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Tacrine",
"alternateName": "Tacrine",
"code": {
"@type": "MedicalCode",
"code": "D013619",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Jan Korabecny",
"url": "https://questionsmedicales.fr/author/Jan%20Korabecny",
"affiliation": {
"@type": "Organization",
"name": "Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic."
}
},
{
"@type": "Person",
"name": "Ondrej Soukup",
"url": "https://questionsmedicales.fr/author/Ondrej%20Soukup",
"affiliation": {
"@type": "Organization",
"name": "Biomedical Research Center; Department of Neurology, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic."
}
},
{
"@type": "Person",
"name": "Vendula Hepnarova",
"url": "https://questionsmedicales.fr/author/Vendula%20Hepnarova",
"affiliation": {
"@type": "Organization",
"name": "Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic."
}
},
{
"@type": "Person",
"name": "Kamil Kuca",
"url": "https://questionsmedicales.fr/author/Kamil%20Kuca",
"affiliation": {
"@type": "Organization",
"name": "Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic."
}
},
{
"@type": "Person",
"name": "Manuela Bartolini",
"url": "https://questionsmedicales.fr/author/Manuela%20Bartolini",
"affiliation": {
"@type": "Organization",
"name": "Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Sub-pocket-focused designing of tacrine derivatives as potential acetylcholinesterase inhibitors.",
"datePublished": "2023-02-11",
"url": "https://questionsmedicales.fr/article/36841058",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.compbiomed.2023.106666"
}
},
{
"@type": "ScholarlyArticle",
"name": "Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease.",
"datePublished": "2023-07-19",
"url": "https://questionsmedicales.fr/article/37487339",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.bmc.2023.117419"
}
},
{
"@type": "ScholarlyArticle",
"name": "Structural and molecular insights into tacrine-benzofuran hybrid induced inhibition of amyloid-β peptide aggregation and BACE1 activity.",
"datePublished": "2023-04-04",
"url": "https://questionsmedicales.fr/article/37013977",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1080/07391102.2023.2191722"
}
},
{
"@type": "ScholarlyArticle",
"name": "1,2,3-Triazolo[4,5-b]aminoquinolines: Design, synthesis, structure, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity, and molecular docking of novel modified tacrines.",
"datePublished": "2023-07-06",
"url": "https://questionsmedicales.fr/article/37453239",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.bioorg.2023.106704"
}
},
{
"@type": "ScholarlyArticle",
"name": "Structure Modification Converts the Hepatotoxic Tacrine into Novel Hepatoprotective Analogs.",
"datePublished": "2024-01-02",
"url": "https://questionsmedicales.fr/article/38250371",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1021/acsomega.3c07126"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Composés hétérocycliques",
"item": "https://questionsmedicales.fr/mesh/D006571"
},
{
"@type": "ListItem",
"position": 3,
"name": "Composés hétérocycliques à cycles fusionnés",
"item": "https://questionsmedicales.fr/mesh/D000072471"
},
{
"@type": "ListItem",
"position": 4,
"name": "Composés hétérocycliques 3 noyaux",
"item": "https://questionsmedicales.fr/mesh/D006575"
},
{
"@type": "ListItem",
"position": 5,
"name": "Acridines",
"item": "https://questionsmedicales.fr/mesh/D000166"
},
{
"@type": "ListItem",
"position": 6,
"name": "Aminoacridines",
"item": "https://questionsmedicales.fr/mesh/D000609"
},
{
"@type": "ListItem",
"position": 7,
"name": "Tacrine",
"item": "https://questionsmedicales.fr/mesh/D013619"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Tacrine - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Tacrine",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2026-02-07",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Tacrine",
"description": "Comment le tacrine est-il utilisé dans le diagnostic ?\nQuels tests précèdent la prescription de tacrine ?",
"url": "https://questionsmedicales.fr/mesh/D013619#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Tacrine",
"description": "Quels symptômes le tacrine aide-t-il à soulager ?\nLe tacrine traite-t-il tous les symptômes d'Alzheimer ?",
"url": "https://questionsmedicales.fr/mesh/D013619#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Tacrine",
"description": "Le tacrine peut-il prévenir la maladie d'Alzheimer ?\nQuelles mesures préventives sont recommandées ?",
"url": "https://questionsmedicales.fr/mesh/D013619#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Tacrine",
"description": "Comment le tacrine est-il administré ?\nQuels sont les effets secondaires du tacrine ?",
"url": "https://questionsmedicales.fr/mesh/D013619#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Tacrine",
"description": "Quelles complications peuvent survenir avec le tacrine ?\nLe tacrine peut-il interagir avec d'autres médicaments ?",
"url": "https://questionsmedicales.fr/mesh/D013619#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Tacrine",
"description": "Qui est à risque de complications avec le tacrine ?\nLe vieillissement est-il un facteur de risque pour le tacrine ?",
"url": "https://questionsmedicales.fr/mesh/D013619#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment le tacrine est-il utilisé dans le diagnostic ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tacrine n'est pas un outil de diagnostic, mais un traitement pour les symptômes d'Alzheimer."
}
},
{
"@type": "Question",
"name": "Quels tests précèdent la prescription de tacrine ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des évaluations cognitives et des antécédents médicaux sont nécessaires avant la prescription."
}
},
{
"@type": "Question",
"name": "Quels symptômes le tacrine aide-t-il à soulager ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il aide à réduire les troubles de la mémoire et la confusion chez les patients d'Alzheimer."
}
},
{
"@type": "Question",
"name": "Le tacrine traite-t-il tous les symptômes d'Alzheimer ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, il ne traite pas tous les symptômes, mais peut améliorer certains aspects cognitifs."
}
},
{
"@type": "Question",
"name": "Le tacrine peut-il prévenir la maladie d'Alzheimer ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, le tacrine ne prévient pas la maladie, il ne fait que traiter les symptômes."
}
},
{
"@type": "Question",
"name": "Quelles mesures préventives sont recommandées ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain, une alimentation équilibrée et des exercices mentaux peuvent aider."
}
},
{
"@type": "Question",
"name": "Comment le tacrine est-il administré ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tacrine est généralement pris par voie orale sous forme de comprimés, plusieurs fois par jour."
}
},
{
"@type": "Question",
"name": "Quels sont les effets secondaires du tacrine ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires peuvent inclure des nausées, des vomissements et des troubles hépatiques."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec le tacrine ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications hépatiques graves peuvent survenir, nécessitant un suivi régulier."
}
},
{
"@type": "Question",
"name": "Le tacrine peut-il interagir avec d'autres médicaments ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tacrine peut interagir avec d'autres médicaments, augmentant le risque d'effets secondaires."
}
},
{
"@type": "Question",
"name": "Qui est à risque de complications avec le tacrine ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les patients avec des antécédents de maladies hépatiques sont à risque accru."
}
},
{
"@type": "Question",
"name": "Le vieillissement est-il un facteur de risque pour le tacrine ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut augmenter la sensibilité aux effets secondaires du tacrine."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 23/11/2025
Contenu vérifié selon les dernières recommandations médicales
12 publications dans cette catégorie
Affiliations :
Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Biomedical Research Center; Department of Neurology, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
12 publications dans cette catégorie
Affiliations :
Biomedical Research Center; Department of Neurology, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
7 publications dans cette catégorie
Affiliations :
Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
7 publications dans cette catégorie
Affiliations :
Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Biomedical Research Center; Department of Neurology, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
6 publications dans cette catégorie
Affiliations :
Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy.
6 publications dans cette catégorie
Affiliations :
Laboratory of Medicinal Chemistry (IQOG, CSIC), 3, Juan de la Cierva, 28006, Madrid, Spain.
6 publications dans cette catégorie
Affiliations :
Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
6 publications dans cette catégorie
Affiliations :
Biomedical Research Center; Department of Neurology, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
5 publications dans cette catégorie
Affiliations :
Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Biomedical Research Center; Department of Neurology, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Publications dans "Tacrine" :
5 publications dans cette catégorie
Affiliations :
Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Biomedical Research Center; Department of Neurology, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Publications dans "Tacrine" :
5 publications dans cette catégorie
Affiliations :
Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Publications dans "Tacrine" :
5 publications dans cette catégorie
Affiliations :
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran, University of Medical Sciences, Tehran, 1416753955, Iran.
Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, 1416753955, Iran.
Publications dans "Tacrine" :
4 publications dans cette catégorie
Affiliations :
Orgánica, Facultad de Química, Universidad de Sevilla, c/Profesor García González 1, 41012, Seville, Spain.
Publications dans "Tacrine" :
4 publications dans cette catégorie
Affiliations :
Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Department of Intensive Medicine and Forensic Studies, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic.
Publications dans "Tacrine" :
4 publications dans cette catégorie
Affiliations :
Biomedical Research Center; Department of Neurology, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870/13, 500 03 Hradec Kralove, Czech Republic.
Publications dans "Tacrine" :
4 publications dans cette catégorie
Affiliations :
Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6/Selmi 3, 40126 Bologna, Italy.
Publications dans "Tacrine" :
4 publications dans cette catégorie
Affiliations :
National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic; Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic.
Publications dans "Tacrine" :
4 publications dans cette catégorie
Affiliations :
National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic; Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic.
Publications dans "Tacrine" :
4 publications dans cette catégorie
Affiliations :
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, 1416753955, Iran.
Publications dans "Tacrine" :
4 publications dans cette catégorie
Affiliations :
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Publications dans "Tacrine" :
Human acetylcholinesterase (hAChE) has a potential role in the management of acetylcholine, one of the neurotransmitters that modulate the overall activity of cholinergic system, AChE inhibitors have ...
Multi-target drug discovery is one of the most active fields in the search for new drugs against Alzheimer's disease (AD). This is because the complexity of AD pathological network might be adequately...
Amyloid-β (Aβ) aggregation and β-amyloid precursor protein cleaving enzyme 1 (BACE1) are the potential therapeutic drug targets for Alzheimer's disease (AD). A recent study highlighted that tacrine-be...
An efficient [4 + 2] cyclization protocol to synthesize a series of twelve examples of 1,2,3-triazolo[4,5-b]aminoquinolines (5) as novel structurally modified tacrines was obtained by reacting readily...
The liver is responsible for critical functions such as metabolism, secretion, storage, detoxification, and the excretion of various compounds. However, there is currently no approved drug treatment f...
The use of privileged scaffolds has proven beneficial for generating novel bioactive scaffolds in drug discovery program. Chromone is one such privileged scaffold that has been exploited for designing...
Alzheimer's disease (AD) is a complex neurodegenerative disease that can lead to the loss of cognitive function. The progression of AD is regulated by multiple signaling pathways and their associated ...
This research is a continuation of previously reported article on anhydrous freebase, cationic and hydrochloride tacrine. Here, structures and properties of di-hydrated species of cholinesterase inhib...
We present our results on the synthesis and preliminary in silico and in vitro studies of the toxicology and antioxidant properties of selenylated analogs of Tacrine. Initially, we synthesized 2-amino...
An enhanced, sustainable, and efficient method for synthesizing tacrine, achieving a 98% yield, has been developed by replacing volatile organic compounds with more eco-friendly solvents such as deep ...