Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase.

Acetylcholinesterase / metabolism Animals Cholinesterase Inhibitors / chemical synthesis Dose-Response Relationship, Drug Drug Development Electrophorus Molecular Structure Structure-Activity Relationship Tacrine / chemical synthesis
Acetylcholinesterase CuAAC multivalent inhibition potency multivalent interactions tacrine

Journal

Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203

Informations de publication

Date de publication:
Dec 2021
Historique:
entrez: 23 7 2021
pubmed: 24 7 2021
medline: 2 9 2021
Statut: ppublish

Résumé

The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold

Identifiants

DOI: 10.1080/14756366.2021.1954917 PMID: 34294013 PMC: PMC8317962
pubmed: 34294013
doi: 10.1080/14756366.2021.1954917
pmc: PMC8317962
doi:

Substances chimiques

Cholinesterase Inhibitors 0
Tacrine 4VX7YNB537
Acetylcholinesterase EC 3.1.1.7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1659-1664

Références

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Auteurs

Tereza Cristina Santos Evangelista (TCS)

Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.
Department of Organic Chemistry, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Óscar López (Ó)

Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.

Sabrina Baptista Ferreira (SB)

Department of Organic Chemistry, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

José G Fernández-Bolaños (JG)

Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.

Magne O Sydnes (MO)

Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.

Emil Lindbäck (E)

Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Development of tacrine clusters as positively...
questionsmedicales.fr › Eucaryotes › Animaux › Development of tacrine clusters as positively...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Development of tacrine clusters as positively...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Development of tacrine clusters as positively...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Development of tacrine clusters as positively...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Poisson électrique › Gymnotiformes › Electrophorus › Development of tacrine clusters as positively...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Development of tacrine clusters as positively...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Development of tacrine clusters as positively...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Acridines › Aminoacridines › Tacrine › Development of tacrine clusters as positively...