The Proof-of-Concept of MBA121, a Tacrine-Ferulic Acid Hybrid, for Alzheimer's Disease Therapy.
APPswe/PS1ΔE9
Alzheimer’s disease
MBA121
beta amyloid
cerebral cortex
ferulic acid
hippocampus
tacrine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Jul 2023
31 Jul 2023
Historique:
received:
19
06
2023
revised:
26
07
2023
accepted:
30
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Great effort has been devoted to the synthesis of novel multi-target directed tacrine derivatives in the search of new treatments for Alzheimer's disease (AD). Herein we describe the proof of concept of MBA121, a compound designed as a tacrine-ferulic acid hybrid, and its potential use in the therapy of AD. MBA121 shows good
Identifiants
pubmed: 37569630
pii: ijms241512254
doi: 10.3390/ijms241512254
pmc: PMC10419016
pii:
doi:
Substances chimiques
Tacrine
4VX7YNB537
ferulic acid
AVM951ZWST
Butyrylcholinesterase
EC 3.1.1.8
Hydrogen Peroxide
BBX060AN9V
Amyloid beta-Peptides
0
Cholinesterase Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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