Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments.
Alzheimer's disease
Cholinesterase inhibition
Friedländer reaction
Hepatotoxicity
Tacrine derivatives
Journal
Chemical record (New York, N.Y.)
ISSN: 1528-0691
Titre abrégé: Chem Rec
Pays: United States
ID NLM: 101085550
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
04
09
2020
revised:
19
10
2020
accepted:
19
10
2020
pubmed:
11
11
2020
medline:
6
7
2021
entrez:
10
11
2020
Statut:
ppublish
Résumé
Herein we have reviewed our recent developments for the identification of new tacrine analogues for Alzheimer's disease (AD) therapy. Tacrine, the first cholinesterase inhibitor approved for AD treatment, did not stop the progression of AD, producing only some cognitive improvements, but exhibited secondary effects mainly due to its hepatotoxicity. Thus, the drug was withdrawn from the clinics administration. Since then, many publications have described non-hepatotoxic tacrines, and in addition, important efforts have been made to design multitarget tacrines by combining their cholinesterase inhibition profile with the modulation of other biological targets involved in AD.
Identifiants
pubmed: 33169934
doi: 10.1002/tcr.202000107
doi:
Substances chimiques
Cholinesterase Inhibitors
0
Neuroprotective Agents
0
Tacrine
4VX7YNB537
Acetylcholinesterase
EC 3.1.1.7
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
162-174Informations de copyright
© 2020 The Chemical Society of Japan & Wiley-VCH GmbH.
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