Design, Synthesis, and Biological Evaluation of Novel Tetrahydroacridin Hybrids with Sulfur-Inserted Linkers as Potential Multitarget Agents for Alzheimer's Disease.
Alzheimer Disease
/ drug therapy
Humans
Cholinesterase Inhibitors
/ pharmacology
Acetylcholinesterase
/ metabolism
Molecular Docking Simulation
Drug Design
Glycogen Synthase Kinase 3 beta
/ antagonists & inhibitors
Cell Line, Tumor
Sulfur
/ chemistry
Structure-Activity Relationship
Acridines
/ chemistry
Tacrine
/ chemistry
Molecular Structure
Alzheimer’s disease
MTDLs
cystamine
inhibitors
molecular modeling
tacrine
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
14 Apr 2024
14 Apr 2024
Historique:
received:
08
03
2024
revised:
11
04
2024
accepted:
12
04
2024
medline:
27
4
2024
pubmed:
27
4
2024
entrez:
27
4
2024
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a complex neurodegenerative disease that can lead to the loss of cognitive function. The progression of AD is regulated by multiple signaling pathways and their associated targets. Therefore, multitarget strategies theoretically have greater potential for treating AD. In this work, a series of new hybrids were designed and synthesized by the hybridization of tacrine (
Identifiants
pubmed: 38675602
pii: molecules29081782
doi: 10.3390/molecules29081782
pii:
doi:
Substances chimiques
Cholinesterase Inhibitors
0
Acetylcholinesterase
EC 3.1.1.7
Glycogen Synthase Kinase 3 beta
EC 2.7.11.1
Sulfur
70FD1KFU70
Acridines
0
Tacrine
4VX7YNB537
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : No. 81874289, 82373743
Organisme : China Pharmaceutical University
ID : CPU2018GY04