Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats.

Rats Male Animals Magnetic Resonance Imaging Stroke Diffusion Magnetic Resonance Imaging Infarction, Middle Cerebral Artery / pathology Reperfusion Diffusion Disease Models, Animal Brain Ischemia / pathology

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
05 04 2023
Historique:
received: 07 07 2022
accepted: 31 03 2023
medline: 7 4 2023
entrez: 5 4 2023
pubmed: 6 4 2023
Statut: epublish

Résumé

Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (ADC) MRI data obtained during MCAO and shortly after reperfusion for their potentials in acute-phase outcome prediction. Fifty-nine male rats underwent a 45-min MCAO. Outcome was defined in three ways: 21-day survival; 24 h midline-shift and neurological scores. Animals were divided into two groups: rats surviving 21 days after MCAO (survival group, n = 46) and rats dying prematurely (non-survival/NS group, n = 13). At reperfusion, NS group showed considerably larger lesion volume and lower mean ADC of the initial lesion site (p < 0.0001), while during occlusion there were no significant group differences. At reperfusion, each survival animal showed decreased lesion volume and increased mean ADC of the initial lesion site compared to those during occlusion (p < 10

Identifiants

DOI: 10.1038/s41598-023-32679-1 PMID: 37019923 PMC: PMC10076321
pubmed: 37019923
doi: 10.1038/s41598-023-32679-1
pii: 10.1038/s41598-023-32679-1
pmc: PMC10076321
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5598

Informations de copyright

© 2023. The Author(s).

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Auteurs

Szilvia Anett Nagy (SA)

ELKH-PTE Clinical Neuroscience MR Research Group, Ret Str. 2, 7623, Pecs, Hungary. szilvia.anett.nagy@gmail.com.
Pecs Diagnostic Centre, Rét Street 2, 7623, Pecs, Hungary. szilvia.anett.nagy@gmail.com.
Structural Neurobiology Research Group, Szentágothai Research Centre, University of Pecs, Ifjúság Street 20, 7624, Pecs, Hungary. szilvia.anett.nagy@gmail.com.
Department of Neurology, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary. szilvia.anett.nagy@gmail.com.

Ivan Ivic (I)

Pecs Diagnostic Centre, Rét Street 2, 7623, Pecs, Hungary.
Selvita d.o.o., Prilaz Baruna Filipovića 29, 10000, Zagreb, Croatia.

Péter Tóth (P)

ELKH-PTE Clinical Neuroscience MR Research Group, Ret Str. 2, 7623, Pecs, Hungary.
Department of Neurosurgery, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary.

Sámuel Komoly (S)

Department of Neurology, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary.

Tamás Kiss (T)

Szentágothai Research Centre, University of Pecs, Ifjúság Street 20, Pecs, Hungary.

Máté Pénzes (M)

Department of Biochemistry, Eötvös Loránd University, Pázmány Péter Sétány 1/C, 1117, Budapest, Hungary.
Motorpharma Ltd., Szilágyi E. Fasor 27, 1026, Budapest, Hungary.

András Málnási-Csizmadia (A)

Motorpharma Ltd., Szilágyi E. Fasor 27, 1026, Budapest, Hungary.
ELKH-ELTE Motor Pharmacology Research Group, Department of Biochemistry, Eötvös Loránd University, Pázmány Péter Sétány 1/C, 1117, Budapest, Hungary.

Tamás Dóczi (T)

Pecs Diagnostic Centre, Rét Street 2, 7623, Pecs, Hungary.
Department of Neurosurgery, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary.

Gábor Perlaki (G)

ELKH-PTE Clinical Neuroscience MR Research Group, Ret Str. 2, 7623, Pecs, Hungary.
Pecs Diagnostic Centre, Rét Street 2, 7623, Pecs, Hungary.
Department of Neurology, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary.
Department of Neurosurgery, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary.

Gergely Orsi (G)

ELKH-PTE Clinical Neuroscience MR Research Group, Ret Str. 2, 7623, Pecs, Hungary.
Pecs Diagnostic Centre, Rét Street 2, 7623, Pecs, Hungary.
Department of Neurology, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary.
Department of Neurosurgery, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Post-reperfusion acute MR diffusion in stroke...
questionsmedicales.fr › Eucaryotes › Animaux › Post-reperfusion acute MR diffusion in stroke...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Post-reperfusion acute MR diffusion in stroke...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Post-reperfusion acute MR diffusion in stroke...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Imagerie par résonance magnétique de diffusion › Post-reperfusion acute MR diffusion in stroke...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus encéphalique › Infarctus cérébral › Infarctus du territoire de l'artère cérébrale moyenne › Post-reperfusion acute MR diffusion in stroke...
questionsmedicales.fr › Techniques d'investigation › Perfusion › Reperfusion › Post-reperfusion acute MR diffusion in stroke...
questionsmedicales.fr › Phénomènes chimiques › Diffusion › Post-reperfusion acute MR diffusion in stroke...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Post-reperfusion acute MR diffusion in stroke...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Encéphalopathie ischémique › Post-reperfusion acute MR diffusion in stroke...