A Multiscale Model for Shear-Mediated Platelet Adhesion Dynamics: Correlating In Silico with In Vitro Results.
Dissipative particle dynamics
GPIbα-vWF bond
Machine learning
Molecular dynamics
Platelet kinematics
Journal
Annals of biomedical engineering
ISSN: 1573-9686
Titre abrégé: Ann Biomed Eng
Pays: United States
ID NLM: 0361512
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
22
11
2022
accepted:
22
03
2023
medline:
25
4
2023
pubmed:
6
4
2023
entrez:
5
4
2023
Statut:
ppublish
Résumé
Platelet adhesion to blood vessel walls is a key initial event in thrombus formation in both vascular disease processes and prosthetic cardiovascular devices. We extended a deformable multiscale model (MSM) of flowing platelets, incorporating Dissipative Particle Dynamics (DPD) and Coarse-Grained Molecular Dynamics (CGMD) describing molecular-scale intraplatelet constituents and their interaction with surrounding flow, to predict platelet adhesion dynamics under physiological flow shear stresses. Binding of platelet glycoprotein receptor Ibα (GPIbα) to von Willebrand factor (vWF) on the blood vessel wall was modeled by a molecular-level hybrid force field and validated with in vitro microchannel experiments of flowing platelets at 30 dyne/cm
Identifiants
pubmed: 37020171
doi: 10.1007/s10439-023-03193-2
pii: 10.1007/s10439-023-03193-2
doi:
Substances chimiques
von Willebrand Factor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1094-1105Subventions
Organisme : NHLBI NIH HHS
ID : U01 HL131052
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131052
Pays : United States
Informations de copyright
© 2023. The Author(s) under exclusive licence to Biomedical Engineering Society.
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