Single-cell analysis of bidirectional reprogramming between early embryonic states reveals mechanisms of differential lineage plasticities.
ES cells
Pluripotency
XEN cells
blastocyst
epiblast
extra-embryonic endoderm
lineage plasticity
primitive endoderm
reprogramming
single-cell analysis
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
29 Mar 2023
29 Mar 2023
Historique:
pubmed:
11
4
2023
medline:
11
4
2023
entrez:
10
4
2023
Statut:
epublish
Résumé
Two distinct fates, pluripotent epiblast (EPI) and primitive (extra-embryonic) endoderm (PrE), arise from common progenitor cells, the inner cell mass (ICM), in mammalian embryos. To study how these sister identities are forged, we leveraged embryonic (ES) and e
Identifiants
pubmed: 37034770
doi: 10.1101/2023.03.28.534648
pmc: PMC10081288
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK127821
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM138635
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD094868
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD035455
Pays : United States
Déclaration de conflit d'intérêts
DECLARATION OF INTERESTS The authors have no competing interests to declare.