An SI3-σ arch stabilizes cyanobacteria transcription initiation complex.
RNA polymerase
cyanobacteria
gene transcription
transcription initiation
transcription initiation factor
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
18 04 2023
18 04 2023
Historique:
medline:
12
4
2023
entrez:
10
4
2023
pubmed:
11
4
2023
Statut:
ppublish
Résumé
Multisubunit RNA polymerases (RNAPs) associate with initiation factors (σ in bacteria) to start transcription. The σ factors are responsible for recognizing and unwinding promoter DNA in all bacterial RNAPs. Here, we report two cryo-EM structures of cyanobacterial transcription initiation complexes at near-atomic resolutions. The structures show that cyanobacterial RNAP forms an "SI3-σ" arch interaction between domain 2 of σ
Identifiants
pubmed: 37036976
doi: 10.1073/pnas.2219290120
pmc: PMC10120043
doi:
Substances chimiques
DNA-Directed RNA Polymerases
EC 2.7.7.6
Sigma Factor
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2219290120Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/W017385/1
Pays : United Kingdom
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