Co-variations of cerebral blood volume and single neurons discharge during resting state and visual cognitive tasks in non-human primates.
CP: Neuroscience
cerebral blood flow
neurovascular coupling
non-human primates
ultrafast ultrasound imaging
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
25 04 2023
25 04 2023
Historique:
received:
18
07
2022
revised:
11
01
2023
accepted:
22
03
2023
medline:
4
10
2023
pubmed:
13
4
2023
entrez:
12
4
2023
Statut:
ppublish
Résumé
To better understand how the brain allows primates to perform various sets of tasks, the ability to simultaneously record neural activity at multiple spatiotemporal scales is challenging but necessary. However, the contribution of single-unit activities (SUAs) to neurovascular activity remains to be fully understood. Here, we combine functional ultrasound imaging of cerebral blood volume (CBV) and SUA recordings in visual and fronto-medial cortices of behaving macaques. We show that SUA provides a significant estimate of the neurovascular response below the typical fMRI spatial resolution of 2mm
Identifiants
pubmed: 37043356
pii: S2211-1247(23)00380-7
doi: 10.1016/j.celrep.2023.112369
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112369Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests M.T. and T.D. are co-inventors of several patents in the field of functional ultrasound neuroimaging and are co-founders of Iconeus, which commercializes ultrasonic neuroimaging scanners.