Antisense oligonucleotide therapy for H3.3K27M diffuse midline glioma.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
12 04 2023
12 04 2023
Historique:
medline:
14
4
2023
entrez:
12
4
2023
pubmed:
13
4
2023
Statut:
ppublish
Résumé
Diffuse midline gliomas (DMGs) are pediatric high-grade brain tumors in the thalamus, midbrain, or pons; the latter subgroup are termed diffuse intrinsic pontine gliomas (DIPG). The brain stem location of these tumors limits the clinical management of DIPG, resulting in poor outcomes for patients. A heterozygous, somatic point mutation in one of two genes coding for the noncanonical histone H3.3 is present in most DIPG tumors. This dominant mutation in the
Identifiants
pubmed: 37043556
doi: 10.1126/scitranslmed.add8280
pmc: PMC10263181
mid: NIHMS1897836
doi:
Substances chimiques
Histones
0
Oligonucleotides, Antisense
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eadd8280Subventions
Organisme : NCI NIH HHS
ID : P01 CA013106
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA045508
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Références
Cancer Cell. 2020 Nov 9;38(5):647-660
pubmed: 32916125
Cancer Cell. 2021 Mar 8;39(3):407-422.e13
pubmed: 33545065
Trends Immunol. 2019 Aug;40(8):748-761
pubmed: 31229353
Clin Dev Immunol. 2013;2013:285246
pubmed: 23983766
Neuron. 2017 Sep 27;96(1):17-42
pubmed: 28957666
Nat Commun. 2019 Mar 4;10(1):1023
pubmed: 30833574
Cancer Cell. 2019 Jan 14;35(1):140-155.e7
pubmed: 30595505
Nat Commun. 2019 Dec 20;10(1):5816
pubmed: 31862977
Mol Cell. 2019 Dec 19;76(6):965-980.e12
pubmed: 31588023
Science. 2014 Aug 29;345(6200):1065-70
pubmed: 25170156
J Clin Invest. 2021 Jan 4;131(1):
pubmed: 32990677
Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4453-8
pubmed: 21368213
Acta Neuropathol. 2019 Apr;137(4):637-655
pubmed: 30770999
Genes Dev. 2015 Jul 1;29(13):1377-92
pubmed: 26159997
Science. 2013 May 17;340(6134):857-61
pubmed: 23539183
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Nat Rev Cancer. 2009 Nov;9(11):798-809
pubmed: 19851315
Prog Neurobiol. 2015 Aug;131:65-86
pubmed: 26067058
Am J Hum Genet. 2008 Apr;82(4):834-48
pubmed: 18371932
J Clin Invest. 2020 Aug 3;130(8):4382-4395
pubmed: 32484800
Cold Spring Harb Protoc. 2014 Nov 03;2014(11):1167-9
pubmed: 25368308
Nature. 2011 Oct 05;478(7367):123-6
pubmed: 21979052
Mol Cancer Res. 2017 Sep;15(9):1243-1254
pubmed: 28522693
Nature. 2020 Jun;582(7813):550-556
pubmed: 32581380
Nat Commun. 2019 Mar 19;10(1):1262
pubmed: 30890717
Nat Genet. 2014 May;46(5):462-6
pubmed: 24705250
Nat Rev Drug Discov. 2020 Oct;19(10):673-694
pubmed: 32782413
Acta Neuropathol. 2015 Dec;130(6):815-27
pubmed: 26399631
Genes Dev. 2010 Aug 1;24(15):1634-44
pubmed: 20624852
Annu Rev Neurosci. 2019 Jul 8;42:385-406
pubmed: 31283897
Science. 2018 Apr 20;360(6386):331-335
pubmed: 29674595
Nat Med. 2018 May;24(5):572-579
pubmed: 29662203
Cell. 2021 Jan 21;184(2):384-403.e21
pubmed: 33450205
J Am Chem Soc. 2014 Oct 1;136(39):13498-501
pubmed: 25180930
Nature. 2022 Mar;603(7903):934-941
pubmed: 35130560
Nat Med. 2015 Jun;21(6):555-9
pubmed: 25939062