Adrian R Krainer

Affiliations

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Publications (29)

Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy.

Cell

Avec: Luciano E Marasco , Gwendal Dujardin , Rui Sousa-Luís , Ying Hsiu Liu , Jose N Stigliano , Tomoki Nomakuchi , Nick J Proudfoot , Adrian R Krainer , Alberto R Kornblihtt

RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.

Nature

Avec: Amina Jbara , Kuan-Ting Lin , Chani Stossel , Zahava Siegfried , Haya Shqerat , Adi Amar-Schwartz , Ela Elyada , Maxim Mogilevsky , Maria Raitses-Gurevich , Jared L Johnson , Tomer M Yaron , Ofek Ovadia , Gun Ho Jang , Miri Danan-Gotthold , Lewis C Cantley , Erez Y Levanon , Steven Gallinger , Adrian R Krainer , Talia Golan , Rotem Karni

Antisense Oligonucleotide Therapeutics for Cystic Fibrosis: Recent Developments and Perspectives.

Molecules and cells

Avec: Young Jin Kim , Adrian R Krainer

SnapShot: Splicing Alterations in Cancer.

Cell

Avec: Mohammad Alinoor Rahman , Adrian R Krainer , Omar Abdel-Wahab

Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia.

Cancer cell

Avec: Eric Wang , Sydney X Lu , Alessandro Pastore , Xufeng Chen , Jochen Imig , Stanley Chun-Wei Lee , Kathryn Hockemeyer , Yohana E Ghebrechristos , Akihide Yoshimi , Daichi Inoue , Michelle Ki , Hana Cho , Lillian Bitner , Andreas Kloetgen , Kuan-Ting Lin , Taisuke Uehara , Takashi Owa , Raoul Tibes , Adrian R Krainer , Omar Abdel-Wahab , Iannis Aifantis

Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy.

Nature communications

Avec: Young Jin Kim , Tomoki Nomakuchi , Foteini Papaleonidopoulou , Lucia Yang , Qian Zhang , Adrian R Krainer

RNA therapeutics.

RNA (New York, N.Y.)

Avec: Michelle L Hastings , Adrian R Krainer

SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Danilo Segovia , Dexter W Adams , Nickolas Hoffman , Polona Safaric Tepes , Tse-Luen Wee , Paolo Cifani , Leemor Joshua-Tor , Adrian R Krainer

Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis.

Cell reports

Avec: SungHee Park , Mattia Brugiolo , Martin Akerman , Shipra Das , Laura Urbanski , Adam Geier , Anil K Kesarwani , Martin Fan , Nathan Leclair , Kuan-Ting Lin , Leo Hu , Ian Hua , Joshy George , Senthil K Muthuswamy , Adrian R Krainer , Olga Anczuków

Modeling RNA-Binding Protein Specificity In Vivo by Precisely Registering Protein-RNA Crosslink Sites.

Molecular cell

Avec: Huijuan Feng , Suying Bao , Mohammad Alinoor Rahman , Sebastien M Weyn-Vanhentenryck , Aziz Khan , Justin Wong , Ankeeta Shah , Elise D Flynn , Adrian R Krainer , Chaolin Zhang

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.

Nature

Avec: Akihide Yoshimi , Kuan-Ting Lin , Daniel H Wiseman , Mohammad Alinoor Rahman , Alessandro Pastore , Bo Wang , Stanley Chun-Wei Lee , Jean-Baptiste Micol , Xiao Jing Zhang , Stephane de Botton , Virginie Penard-Lacronique , Eytan M Stein , Hana Cho , Rachel E Miles , Daichi Inoue , Todd R Albrecht , Tim C P Somervaille , Kiran Batta , Fabio Amaral , Fabrizio Simeoni , Deepti P Wilks , Catherine Cargo , Andrew M Intlekofer , Ross L Levine , Heidi Dvinge , Robert K Bradley , Eric J Wagner , Adrian R Krainer , Omar Abdel-Wahab

Recurrent SRSF2 mutations in MDS affect both splicing and NMD.

Genes & development

Avec: Mohammad Alinoor Rahman , Kuan-Ting Lin , Robert K Bradley , Omar Abdel-Wahab , Adrian R Krainer

Screening Splice-Switching Antisense Oligonucleotides in Pancreas-Cancer Organoids.

Nucleic acid therapeutics

Avec: Ledong Wan , Alexander J Kral , Dillon Voss , Balázs Schäfer , Kavitha Sudheendran , Mathias Danielsen , Marvin H Caruthers , Adrian R Krainer

ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth.

Cancer research

Avec: Wai Kit Ma , Dillon M Voss , Juergen Scharner , Ana S H Costa , Kuan-Ting Lin , Hyun Yong Jeon , John E Wilkinson , Michaela Jackson , Frank Rigo , C Frank Bennett , Adrian R Krainer

Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer.

Cancer discovery

Avec: Ledong Wan , Kuan-Ting Lin , Mohammad Alinoor Rahman , Yuma Ishigami , Zhikai Wang , Mads A Jensen , John E Wilkinson , Youngkyu Park , David A Tuveson , Adrian R Krainer

Specificity, synergy, and mechanisms of splice-modifying drugs.

Nature communications

Avec: Yuma Ishigami , Mandy S Wong , Carlos Martí-Gómez , Andalus Ayaz , Mahdi Kooshkbaghi , Sonya M Hanson , David M McCandlish , Adrian R Krainer , Justin B Kinney

Higher-order epistasis and phenotypic prediction.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Juannan Zhou , Mandy S Wong , Wei-Chia Chen , Adrian R Krainer , Justin B Kinney , David M McCandlish

Antisense oligonucleotide therapy for H3.3K27M diffuse midline glioma.

Science translational medicine

Avec: Qian Zhang , Lucia Yang , Ying Hsiu Liu , John E Wilkinson , Adrian R Krainer

SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia.

Leukemia

Avec: Joanna R Sinnakannu , Kian Leong Lee , Shanshan Cheng , Jia Li , Mengge Yu , Siew Peng Tan , Clara Chong Hui Ong , Huihua Li , Hein Than , Olga Anczuków-Camarda , Adrian R Krainer , Xavier Roca , Steven G Rozen , Jabed Iqbal , Henry Yang , Charles Chuah , Sin Tiong Ong

Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model.

Nucleic acids research

Avec: Lei Sheng , Frank Rigo , C Frank Bennett , Adrian R Krainer , Yimin Hua

Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor.

Molecular therapy. Nucleic acids

Avec: Juergen Scharner , Sabrina Qi , Frank Rigo , C Frank Bennett , Adrian R Krainer

PSI-Sigma: a comprehensive splicing-detection method for short-read and long-read RNA-seq analysis.

Bioinformatics (Oxford, England)

Avec: Kuan-Ting Lin , Adrian R Krainer

Antisense Oligonucleotide Therapies for Neurodegenerative Diseases.

Annual review of neuroscience

Avec: C Frank Bennett , Adrian R Krainer , Don W Cleveland

Disruption of splicing-regulatory elements using CRISPR/Cas9 to rescue spinal muscular atrophy in human iPSCs and mice.

National science review

Avec: Jin-Jing Li , Xiang Lin , Cheng Tang , Ying-Qian Lu , Xinde Hu , Erwei Zuo , He Li , Wenqin Ying , Yidi Sun , Lu-Lu Lai , Hai-Zhu Chen , Xin-Xin Guo , Qi-Jie Zhang , Shuang Wu , Changyang Zhou , Xiaowen Shen , Qifang Wang , Min-Ting Lin , Li-Xiang Ma , Ning Wang , Adrian R Krainer , Linyu Shi , Hui Yang , Wan-Jin Chen

Systematic characterization of short intronic splicing-regulatory elements in SMN2 pre-mRNA.

Nucleic acids research

Avec: Yuan Gao , Kuan-Ting Lin , Tao Jiang , Yang Yang , Mohammad A Rahman , Shuaishuai Gong , Jialin Bai , Li Wang , Junjie Sun , Lei Sheng , Adrian R Krainer , Yimin Hua

Exon-skipping antisense oligonucleotides for cystic fibrosis therapy.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Young Jin Kim , Nicole Sivetz , Jessica Layne , Dillon M Voss , Lucia Yang , Qian Zhang , Adrian R Krainer

Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides.

Nucleic acids research

Avec: Juergen Scharner , Wai Kit Ma , Qian Zhang , Kuan-Ting Lin , Frank Rigo , C Frank Bennett , Adrian R Krainer

Identification of SRSF10 as a regulator of SMN2 ISS-N1.

Human mutation

Avec: Sabrina B Frederiksen , Lise L Holm , Martin R Larsen , Thomas K Doktor , Henriette S Andersen , Michelle L Hastings , Yimin Hua , Adrian R Krainer , Brage S Andresen

Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia.

Nature communications

Avec: Masahiko Ajiro , Tomonari Awaya , Young Jin Kim , Kei Iida , Masatsugu Denawa , Nobuo Tanaka , Ryo Kurosawa , Shingo Matsushima , Saiko Shibata , Tetsunori Sakamoto , Lorenz Studer , Adrian R Krainer , Masatoshi Hagiwara

Réseau de co-auteurs

Kuan-Ting Lin 10 collaborations

Mohammad Alinoor Rahman 5 collaborations

C Frank Bennett 5 collaborations

Young Jin Kim 4 collaborations

Omar Abdel-Wahab 4 collaborations

Qian Zhang 4 collaborations

Frank Rigo 4 collaborations

Lucia Yang 3 collaborations

Juergen Scharner 3 collaborations

John E Wilkinson 3 collaborations

Yimin Hua 3 collaborations

Ying Hsiu Liu 2 collaborations

Tomoki Nomakuchi 2 collaborations

Alessandro Pastore 2 collaborations

Stanley Chun-Wei Lee 2 collaborations

Akihide Yoshimi 2 collaborations

Daichi Inoue 2 collaborations

Hana Cho 2 collaborations

Michelle L Hastings 2 collaborations

Robert K Bradley 2 collaborations

Ledong Wan 2 collaborations

Wai Kit Ma 2 collaborations

Dillon M Voss 2 collaborations

Yuma Ishigami 2 collaborations

Mandy S Wong 2 collaborations

David M McCandlish 2 collaborations

Justin B Kinney 2 collaborations

Lei Sheng 2 collaborations

Luciano E Marasco 1 collaboration

Gwendal Dujardin 1 collaboration

Rui Sousa-Luís 1 collaboration

Jose N Stigliano 1 collaboration

Nick J Proudfoot 1 collaboration

Alberto R Kornblihtt 1 collaboration

Amina Jbara 1 collaboration

Chani Stossel 1 collaboration

Zahava Siegfried 1 collaboration

Haya Shqerat 1 collaboration

Adi Amar-Schwartz 1 collaboration

Ela Elyada 1 collaboration

Maxim Mogilevsky 1 collaboration

Maria Raitses-Gurevich 1 collaboration

Jared L Johnson 1 collaboration

Tomer M Yaron 1 collaboration

Ofek Ovadia 1 collaboration

Gun Ho Jang 1 collaboration

Miri Danan-Gotthold 1 collaboration

Lewis C Cantley 1 collaboration

Erez Y Levanon 1 collaboration

Steven Gallinger 1 collaboration

Talia Golan 1 collaboration

Rotem Karni 1 collaboration

Eric Wang 1 collaboration

Sydney X Lu 1 collaboration

Xufeng Chen 1 collaboration

Jochen Imig 1 collaboration

Kathryn Hockemeyer 1 collaboration

Yohana E Ghebrechristos 1 collaboration

Michelle Ki 1 collaboration

Lillian Bitner 1 collaboration

Andreas Kloetgen 1 collaboration

Taisuke Uehara 1 collaboration

Takashi Owa 1 collaboration

Raoul Tibes 1 collaboration

Iannis Aifantis 1 collaboration

Foteini Papaleonidopoulou 1 collaboration

Danilo Segovia 1 collaboration

Dexter W Adams 1 collaboration

Nickolas Hoffman 1 collaboration

Polona Safaric Tepes 1 collaboration

Tse-Luen Wee 1 collaboration

Paolo Cifani 1 collaboration

Leemor Joshua-Tor 1 collaboration

SungHee Park 1 collaboration

Mattia Brugiolo 1 collaboration

Martin Akerman 1 collaboration

Shipra Das 1 collaboration

Laura Urbanski 1 collaboration

Adam Geier 1 collaboration

Anil K Kesarwani 1 collaboration

Martin Fan 1 collaboration

Nathan Leclair 1 collaboration

Leo Hu 1 collaboration

Ian Hua 1 collaboration

Joshy George 1 collaboration

Senthil K Muthuswamy 1 collaboration

Olga Anczuków 1 collaboration

Huijuan Feng 1 collaboration

Suying Bao 1 collaboration

Sebastien M Weyn-Vanhentenryck 1 collaboration

Aziz Khan 1 collaboration

Justin Wong 1 collaboration

Ankeeta Shah 1 collaboration

Elise D Flynn 1 collaboration

Chaolin Zhang 1 collaboration

Daniel H Wiseman 1 collaboration

Bo Wang 1 collaboration

Jean-Baptiste Micol 1 collaboration

Xiao Jing Zhang 1 collaboration

Stephane de Botton 1 collaboration

Virginie Penard-Lacronique 1 collaboration

Eytan M Stein 1 collaboration

Rachel E Miles 1 collaboration

Todd R Albrecht 1 collaboration

Tim C P Somervaille 1 collaboration

Kiran Batta 1 collaboration

Fabio Amaral 1 collaboration

Fabrizio Simeoni 1 collaboration

Deepti P Wilks 1 collaboration

Catherine Cargo 1 collaboration

Andrew M Intlekofer 1 collaboration

Ross L Levine 1 collaboration

Heidi Dvinge 1 collaboration

Eric J Wagner 1 collaboration

Alexander J Kral 1 collaboration

Dillon Voss 1 collaboration

Balázs Schäfer 1 collaboration

Kavitha Sudheendran 1 collaboration

Mathias Danielsen 1 collaboration

Marvin H Caruthers 1 collaboration

Ana S H Costa 1 collaboration

Hyun Yong Jeon 1 collaboration

Michaela Jackson 1 collaboration

Zhikai Wang 1 collaboration

Mads A Jensen 1 collaboration

Youngkyu Park 1 collaboration

David A Tuveson 1 collaboration

Carlos Martí-Gómez 1 collaboration

Andalus Ayaz 1 collaboration

Mahdi Kooshkbaghi 1 collaboration

Sonya M Hanson 1 collaboration

Juannan Zhou 1 collaboration

Wei-Chia Chen 1 collaboration

Joanna R Sinnakannu 1 collaboration

Kian Leong Lee 1 collaboration

Shanshan Cheng 1 collaboration

Jia Li 1 collaboration

Mengge Yu 1 collaboration

Siew Peng Tan 1 collaboration

Clara Chong Hui Ong 1 collaboration

Huihua Li 1 collaboration

Hein Than 1 collaboration

Olga Anczuków-Camarda 1 collaboration

Xavier Roca 1 collaboration

Steven G Rozen 1 collaboration

Jabed Iqbal 1 collaboration

Henry Yang 1 collaboration

Charles Chuah 1 collaboration

Sin Tiong Ong 1 collaboration

Sabrina Qi 1 collaboration

Don W Cleveland 1 collaboration

Jin-Jing Li 1 collaboration

Xiang Lin 1 collaboration

Cheng Tang 1 collaboration

Ying-Qian Lu 1 collaboration

Xinde Hu 1 collaboration

Erwei Zuo 1 collaboration

He Li 1 collaboration

Wenqin Ying 1 collaboration

Yidi Sun 1 collaboration

Lu-Lu Lai 1 collaboration

Hai-Zhu Chen 1 collaboration

Xin-Xin Guo 1 collaboration

Qi-Jie Zhang 1 collaboration

Shuang Wu 1 collaboration

Changyang Zhou 1 collaboration

Xiaowen Shen 1 collaboration

Qifang Wang 1 collaboration

Min-Ting Lin 1 collaboration

Li-Xiang Ma 1 collaboration

Ning Wang 1 collaboration

Linyu Shi 1 collaboration

Hui Yang 1 collaboration

Wan-Jin Chen 1 collaboration

Yuan Gao 1 collaboration

Tao Jiang 1 collaboration

Yang Yang 1 collaboration

Mohammad A Rahman 1 collaboration

Shuaishuai Gong 1 collaboration

Jialin Bai 1 collaboration

Li Wang 1 collaboration

Junjie Sun 1 collaboration

Nicole Sivetz 1 collaboration

Jessica Layne 1 collaboration

Sabrina B Frederiksen 1 collaboration

Lise L Holm 1 collaboration

Martin R Larsen 1 collaboration

Thomas K Doktor 1 collaboration

Henriette S Andersen 1 collaboration

Brage S Andresen 1 collaboration

Masahiko Ajiro 1 collaboration

Tomonari Awaya 1 collaboration

Kei Iida 1 collaboration

Masatsugu Denawa 1 collaboration

Nobuo Tanaka 1 collaboration

Ryo Kurosawa 1 collaboration

Shingo Matsushima 1 collaboration

Saiko Shibata 1 collaboration

Tetsunori Sakamoto 1 collaboration

Lorenz Studer 1 collaboration

Masatoshi Hagiwara 1 collaboration